Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications / Edition 1

Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications / Edition 1

by Shaoguang Li
     
 

ISBN-10: 0387691308

ISBN-13: 9780387691305

Pub. Date: 08/09/2008

Publisher: Springer New York

In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try

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Overview

In this book, Dr. Li and his author team plan to emphasize why mouse models are useful in vivo systems for understanding disease mechanisms and developing therapeutic strategies in blood cancers. The authors do not intend to cover all types of blood cancers; instead, they will focus on some major ones such as leukemias and lymphomas. However, the authors will try to cover as much as they can the cancer types and point out that many blood cancers need to be studied in mouse disease models although they are still not available at present. A major focus in the book will be to show what we can or cannot learn from mouse disease models and to also show the critical contributions of mouse models in therapeutic drug development.

Product Details

ISBN-13:
9780387691305
Publisher:
Springer New York
Publication date:
08/09/2008
Edition description:
2008
Pages:
293
Product dimensions:
6.30(w) x 9.30(h) x 0.80(d)

Table of Contents

Chapter 1

Mouse models of myeloproliferative disease associated with mutant JAK2 tyrosine kinase: insights into pathophysiology and therapy

Richard A. Van Etten

Chapter 2

Genetic modeling of human blood cancers in mice

Yiguo Hu and Shaoguang Li

Chapter 3

Murine Models of Hematopoietic Disease: Pathologic Analysis and Characterization

Benjamin H Lee and Jeffery L. Kutok

Chapter 4

Mechanisms of DNA double strand break repair in hematopoietic homeostasis and oncogenesis

Sarah A. Maas, Lura Brianna Caddle, and Kevin D. Mills

Chapter 5

Modeling human leukemia using immune-compromised mice

F Ishikawa, Y Saito, and LD Shultz

Chapter 6

Dietary Restriction: A model system probing the cell fate decision between cancer and senescence

Robin P. Ertl and David E. Harrison

Chapter 7

Modeling human Philadelphia chromosome-positive leukemia in mice

Shaoguang Li

Chapter 8

Mouse Models of Human Mature B Cell and Plasma Cell Neoplasms

Siegfried Janz, Herbert C. Morse III, and Michael A. Teitell

Chapter 9

Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh

Hiroshi Hiai

Chapter 10

Animal cancer models in anticancer drug discovery and development

Francis Lee and Roberto Weinmann

Bristol-Myers Squibb Oncology, Princeton, New Jersey, USA

Chapter 11

DGL Global Strategies in DNA Microarray Gene Expression Analysis and Data Mining for Human Blood Cancers

Dongguang Li

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