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Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications / Edition 1

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Overview

Although it remains an open question among some people whether mice and humans are similar in disease development, the laboratory mouse has emerged as the preeminent animal model for human diseases. This is underscored by the recently completed mouse and human genome projects, which have revealed that mice and humans share the vast majority of their genes, and thus get many of the same diseases, and for the same reasons. Emphasizing why mouse models are valuable in vivo systems for understanding disease mechanisms and developing therapeutic strategies for human blood cancers, "Mouse Models of Human Blood Cancers: Basic Research and Pre-clinical Applications," edited by Shaoguang Li, aims on presenting thorough analyses of the pathological features and the molecular bases of several major types of blood cancer and to describe translational research using mouse cancer models.

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Product Details

  • ISBN-13: 9780387691305
  • Publisher: Springer New York
  • Publication date: 8/9/2008
  • Edition description: 2008
  • Edition number: 1
  • Pages: 293
  • Product dimensions: 6.30 (w) x 9.30 (h) x 0.80 (d)

Table of Contents

Chapter 1 Mouse models of myeloproliferative disease associated with mutant JAK2 tyrosine kinase: insights into pathophysiology and therapy
Richard A. Van Etten Chapter 2 Genetic modeling of human blood cancers in mice Yiguo Hu and Shaoguang Li Chapter 3 Murine Models of Hematopoietic Disease: Pathologic Analysis and Characterization Benjamin H Lee and Jeffery L. Kutok Chapter 4 Mechanisms of DNA double strand break repair in hematopoietic homeostasis and oncogenesis Sarah A. Maas, Lura Brianna Caddle, and Kevin D. Mills Chapter 5 Modeling human leukemia using immune-compromised mice F Ishikawa, Y Saito, and LD Shultz Chapter 6 Dietary Restriction: A model system probing the cell fate decision between cancer and senescence Robin P. Ertl and David E. Harrison Chapter 7 Modeling human Philadelphia chromosome-positive leukemia in mice Shaoguang Li Chapter 8 Mouse Models of Human Mature B Cell and Plasma Cell Neoplasms Siegfried Janz, Herbert C. Morse III, and Michael A. Teitell Chapter 9 Genetic and Virological Predisposition to Pre-B Lymphomagenesis in SL/Kh Hiroshi Hiai Chapter 10 Animal cancer models in anticancer drug discovery and development Francis Lee and Roberto Weinmann Bristol-Myers Squibb Oncology, Princeton, New Jersey, USA Chapter 11 DGL Global Strategies in DNA Microarray Gene Expression Analysis and Data Mining forHuman Blood Cancers Dongguang Li

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