Mouse Models of Human Cancer / Edition 1

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Mice have become the species of choice for modeling the complex interactions between tumor cells and the host environment. Mouse genetics are easily manipulated, and a growing array of technology exists for this purpose. Mouse models allow investigators to better understand causal relationships between specific genetic alterations and tumors, utilize new imaging techniques, and test novel therapies. Recent developments along these lines show great promise for the development of new anti-cancer treatments.

Mouse Models of Human Cancer provides researchers and students with a complete resource on the subject, systematically presenting the principles, methodologies, applications, and challenges associated with this exciting field. Offering a survey of the latest research and a description of future areas of interest, this text:

  • Presents real experimental data
  • Describes organ site-specific mouse models
  • Clearly identifies suitable models for further drug testing
  • Critically analyzes current methodologies and their limitations
  • Features numerous recognizable expert contributors
  • Lists key Web sites, reagents, and companies

From mouse handling and genetic engineering to preclinical trials, Mouse Models of Human Cancer is a comprehensive guide to using these models and relating them to human disease. Its uniform presentation describes organ-specific models in clinical, imaging, and molecular terms, and lays out the relevant genetics, experimental approaches, histological comparisons with human disease, and conclusions.

Combining stellar chapter authors, rich illustrations, and clear, up-to-date coverage, Mouse Models of Human Cancer is an invaluable resource for advanced students and cutting-edge researchers.

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Editorial Reviews

From the Publisher
"…well written and easy to read...a valuable addition to the shelf of those currently modeling human cancer." (Journal of Natural Products, June 2005)

" excellent, useful reference for pathologists and scientists interested in mice as models for studying human cancer." (Veterinary Pathology, May 2005)

"…this text would make an excellent resource for any library trying to assist their researchers to know where this field has been and where it is going." (E-STREAMS, April 2005)

Doody's Review Service
Reviewer: Jill C. Pelling, PhD (Northwestern University Feinberg School of Medicine)
Description: This book reviews the principles, methodology, and applications of various mouse models of human cancer. Divided into five sections, the book deals with mouse handling and genetic engineering, description and characterization of mouse models in eight organ sites, discussion of specific cancer biology issues such as angiogenesis and metastasis, comparison of various imaging technologies for mouse models, and a discussion of the use of mouse models in preclinical trials.
Purpose: The purpose is to provide students and cancer researchers with an overview of the basic concepts and fundamental methods employed in developing and engineering mouse models, to show appropriate examples of experimental approaches using these mice, and to provide perspectives on future directions and issues in mouse modeling. These are important objectives in a rapidly expanding and competitive research field, and Dr. Holland has compiled an impressive array of contributors to meet these objectives.
Audience: Dr. Holland has targeted this book at advanced students and researchers in the field. The book provides historical context for students interested in the development of mouse models, and covers basic concepts involved in genetically engineered mice, fundamental discussion of cancer biology, and the applications and limitations of available mouse models for eight organ sites. Dr. Holland heads a research laboratory at Sloan-Kettering Institute that investigates molecular mechanisms of CNS tumor pathogenesis and the modeling of these cancers in mice.
Features: This book presents an overview of important issues in mouse handling and engineering of genetically modified mice. A substantial effort has been made to provide readers with reviews of many of the current specific mouse models for human cancer in eight different organ sites, including lung, mammary gland, prostate, skin, ovary, peripheral and central nervous system, myeloid malignancies and lymphoid malignancies. Many of the contributors have addressed areas in which models are needed. Although eight organ sites are covered in this book, missing from the list is the area of colon carcinogenesis and discussion of the available mouse models to investigate this common human cancer. This book also provides discussions on the critical roles played by genetic modifiers, blood vessel formation, metastasis and tumor immunology in mouse tumorigenesis in genetically engineered mice. Other chapters address issues related to biostatistics, pharmacokinetics/pharmacodynamics and in vivo imaging of mouse tumors. Attention is also paid to discussion of general principles involved in testing cancer therapeutic agents in mice and how various murine models can be employed to overcome difficulties encountered in evaluating the efficacy of new agents in humans. Particularly noteworthy are the helpful references to useful Web sites, such as Table 1.1, which provides information on distributors, databases, and the website addresses for accessing information. The black-and-white diagrams are for the most part clear and well-executed, with the exception of some of the histopathologic panels which lack sufficient contrast. A series of color glossy figures is also provided, covering imaging and histopathology of normal and malignant mouse tissues and comparison with some human tumors.
Assessment: Overall this is a well crafted textbook for graduate students and researchers in carcinogenesis research who wish to learn more about the pertinent issues involved in genetic manipulation of mouse tumor models and the usefulness, as well as the limitations, of available mouse models.

3 Stars from Doody
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Product Details

  • ISBN-13: 9780471444602
  • Publisher: Wiley
  • Publication date: 8/28/2004
  • Edition number: 1
  • Pages: 482
  • Product dimensions: 8.66 (w) x 11.24 (h) x 1.13 (d)

Meet the Author

Eric Holland received his Ph.D. from the University of Chicago in 1985 and M.D. from Stanford University in 1990.  He completed his residency in neurosurgery at UCLA and did postdoctoral work at Stanford and the NIH.  He holds appointments at Memorial Sloan-Kettering Cancer Center and Cornell University.  He is a clinically active neurosurgeon and heads a laboratory at the Sloan-Kettering Institute focused primarily on understanding the molecular mechanisms underlying the pathogenesis of CNS tumors and in modeling these cancers in the mouse. Dr. Holland is the recipient of the Searle Scholars Award, the American Brain Tumor Association Research Award, the Peter Steck Memorial Award, the Bressler Scholars Award and the Seroussi Award.  He has served on the NIH Brain Tumor Process Review Group, is a member of the Mouse Models of Human Cancer Consortium and is the Principal Investigator of the Brain Tumor SPORE program at MSKCC

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Table of Contents




1. Approaches to Handling, Breeding, Strain Preservation, Genotyping, and Drug Administration for Mouse Models of Cancer (Dawnalyn Boggess, Kathleen A. Silva, Carlisle P. Landel, Larry Mobraaten, and John P. Sundberg).

2. Pathology of Mouse Models of Cancer (Robert D. Cardiff).

3. Intercurrent Infections in Genetically Engineered Mice (Stephen W. Barthold).

4. Germline Modification Strategies (Silvia Grisendi and Pier Paolo Pandolfi).

5. Somatic Cell Gene Transfer (Lene Uhrbom and Eric C. Holland).


6. Lung Cancer (Jonathan M. Kurie, Parviz Minoo, Stephen S. Hecht, Alexander Nikitin, and Franco J. DeMayo).

7. Mammary Gland Cancer (Dalit Barkan, Cristina Montagna, Thomas Ried, and Jeffrey E. Green).

8. Prostate Cancer (Katharine Ellwood-Yen and Charles Sawyers).

9. Skin Cancer (Marcus Bosenberg).

10. Ovarian Cancer (Sandra Orsulic).

11. Peripheral Nervous System Tumors (David H. Gutmann, Arie Perry, Reshma Rangwala, and Larry S. Sherman).

12. Central Nervous System Tumors (Andrew B. Lassman and Eric C. Holland).

13. Myeloid Malignancies (Scott C. Kogan).

14. Lymphoid Malignancies (Michael Teitell and Pier Paolo Pandolfi).


15. Genetic Modifiers (David W. Threadgill, Kent W. Hunter, Fei Zou, and Kenneth F. Manly).

16. Modeling Blood Vessel Formation in the Mouse (Robert Benezra, Shahin Rafii, and David Lyden).

17. Metastasis (Dawn S. Chandler and Guillermina Lozano).

18. Immunologic Study of Tumors in Mouse Models (Taha Merghoub and Alan N. Houghton).


19. Micro–Computed Tomography of Mouse Cancer Models (Jamey P. Weichert).

20 .Magnetic Resonance Imaging in Mouse Cancer Models (Manickam Muruganandham and Jason A. Koutcher).

21. Bioluminescent Imaging of Mouse Cancer Models (Christopher H. Contag).


22 .Use of Magnetic Resonance Imaging for Evaluation of Treatment Response (Brian D. Ross, Thomas L. Chenevert, Bradford A. Moffat, Alnawaz Rehemtulla, Daniel E. Hall, Patrick McConville, and Jonathan Moody).

23. Physiologically Based Pharmacokinetic and Pharmacodynamic Modeling (Raymond S. H. Yang, James E. Dennison, Melvin E. Andersen, Ying C. Ou, Kai H. Liao, and Brad Reisfeld).

24. Trial Design and Biostatistics (Michael F. W. Festing).

25. Cancer Drug Development in the Modern Era (William R. Sellers and Alex Matter).

26. Preclinical Trials in Mouse Cancer Models (Brian Weiss and Kevin Shannon).


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