Mouth Dissolving Tablet of Olanzapine by Solid Dispersion Technique

Mouth Dissolving Tablet of Olanzapine by Solid Dispersion Technique

by Vishal Brahmbhatt, Natvarlal M. Patel, Mukesh Patel
     
 
In the present investigation, solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch

Overview

In the present investigation, solid dispersion of olanzapine has been prepared to improve its solubility. Further, using solid dispersion, mouth dissolving tablet was prepared to overcome the problem of swallowing. A Simplex Lattice design was applied using three factors, i.e. superdisintegrants like croscarmellose sodium(X1) crospovidone(X2), and sodium starch glycolate(X3) in tablet formulation. Disintegration time, Wetting time, Water absorption, T50 (Time required to 50% drug release) and Q10 (percentage of drug released in 10 min.) taken as responses. Solid dispersion showed significant enhancement in solubility of olanzapine. For mouth dissolving tablet, batch containing 5% croscarmellose sodium alone had minimum disintegration time (44 sec.) and faster drug release(T50: 40 sec) compared to other batches.

Product Details

ISBN-13:
9783659133084
Publisher:
OmniScriptum GmbH & Co. KG
Publication date:
05/30/2012
Pages:
136
Product dimensions:
6.00(w) x 9.00(h) x 0.32(d)

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