Multimodal Concepts for Integration of Cytotoxic Drugs / Edition 1

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The first part of this book summarizes the rationale and the preclinical data for combined treatment with ionizing radiation and pharmaceutical agents. Individual chapters focus on forms of combined treatment, with due consideration being given to a range of drugs and to emerging combinations with small molecules and antibodies. The second part comprises a series of disease-specific chapters in which the clinical results of combined modality treatment are presented.

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Editorial Reviews

Doody's Review Service
Reviewer: James G Douglas, MD, MS (Memorial Hospital of Sweetwater County)
Description: Organized by disease sites, this book provides a clinical, scientific rationale for the combination treatment of radiation and chemotherapy for cancer patients.
Purpose: The objectives are to help clinicians and researchers involved in combination treatment to understand the rationale for particular drug and radiotherapy combinations as well as the interactions of drug agents with radiotherapy. This book clearly meets these goals by presenting the preclinical scientific data as well as results of clinical trials of such combination therapy.
Audience: Clinicians and researchers who treat patients with malignancies with multimodality therapy are the intended readers. The authors are recognized for their contributions in radiation oncology and medical oncology.
Features: The book focuses on the interaction of radiotherapy with chemotherapy agents both for tumor effects as well as normal tissue effects. The first of the book's two parts deals with the preclinical data for the combined use of chemoradiotherapy with excellent descriptions of the action of particular chemotherapy agents and radiation. The second part is devoted to a thorough but clear examination of the clinical trials using combined modality therapy. Excellently designed tables and figures emphasize particular points in the book.
Assessment: This is a well written, concise source for the scientific rationale for and results of combined chemoradiotherapy. It is an invaluable reference source on this subject and should be a part of all radiation oncologists' and medical oncologists' libraries.
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Product Details

  • ISBN-13: 9783642065057
  • Publisher: Springer Berlin Heidelberg
  • Publication date: 12/15/2009
  • Series: Medical Radiology / Radiation Oncology Series
  • Edition description: Softcover reprint of hardcover 1st ed. 2006
  • Edition number: 1
  • Pages: 352
  • Product dimensions: 8.10 (w) x 10.80 (h) x 0.90 (d)

Meet the Author

J. Martin Brown, PhD, is a Professor of Radiation Oncology at Stanford University. He was president of the Radiation Research Society and member of several program and award committees of the American Association for Cancer Research. Dr. Brown is currently the senior editor for biology for the International Journal of Radiation Oncology Biology Physics. He has received a number of awards, including an NIH M.E.R.I.T. Award, the Research Award from the Radiation Research Society, the 1999 Cain Memorial Award from the American Association for Cancer Research, the 1999 ASTRO Gold Medal, and the Weiss Medal from the Association for Radiation Research.

Minesh P. Mehta, MD, is Professor and Chairman of the Department of Human Oncology, University of Wisconsin Medical School, Madison. He is the Chairman of the Radiation Therapy Oncology Group Brain Tumor Committee and is on the editorial board of the Journal of Neuro-Oncology and the International Journal of Cancer Research.

Carsten Nieder, MD, is head of the Radiation Oncology Section of the Multidisciplinary Cancer Center and deputy head of the Stereotactic Central Nervous System Radiotherapy program, Klinikum rechts der Isar, Munich. He has received a 2-year research scholarship from the Mildred Scheel Foundation and the Hanns Langendorff Award 2003. Dr. Nieder is on the editorial board of Reviews of Recent Randomized Trials.

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Table of Contents

Preclinical Part.- Biological Basis of Combined Radio- and Chemotherapy.- Combinations of Antimetabolites and Ionizing Radiation.- Combinations of Taxanes and Ionizing Radiation.- Combinations of Topoisomerase Inhibitors and Ionizing Radiation.- Combinations of Hypoxia-Targeting Compounds and Radiation-Activated Prodrugs with Ionizing Radiation.- Combinations of Platinum Compounds and Ionizing Radiation.- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Angiogenesis Inhibitors.- Combinations of Cytotoxic Drugs, Ionizing Radiation and EGFR Inhibitors.- Combinations of Cytotoxic Drugs, Ionizing Radiation, and Mammalian Target of Rapamycin (mTOR) Inhibitors.- Combinations of Ionizing Radiation and Other Sensitizing Agents.- Radiotherapy and Tumor-Targeted Drug Delivery.- Clinical Part.- Applications in Malignant Brain Tumors.- Applications in Head and Neck Cancer.- Applications in Esophageal and Gastric Cancer.- Novel Chemoradiation in Localized Pancreatic Cancer: Clinical Studies.- Applications in Lung Cancer.- Integration of Radiation Therapy and Systemic Therapy for Breast Cancer.- Applications in Rectal and Anal Cancer.- Concomitant Radiation and Chemotherapy in Muscle-Invasive Bladder Cancer.- Applications to Gynecological Cancers.- Early and Late Treatment-Induced Toxicity.- Feasibility of Combined Chemo- and Radiation Treatment in Elderly/Comorbid Patients.
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