Muscle Biopsy: A Practical Approach / Edition 3

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In this book, Professor Victor Dubowitz manages to bridge the gap between clinical syndromes/disorders and their underlying pathologies. An internationally renowned figure in the field of muscle disease, Professor Dubowitz skillfully guides you through the complexities of pathologic diagnoses and their implications for clinical treatment. This reference describes the techniques of obtaining a muscle biopsy and examines the histochemical, histological, electron microscopical and molecular appearance of normal muscle and the pathology of individual muscle disease.

• Covers the entire range of diagnostic/investigative techniques, providing you with all of the necessary tools to formulate an accurate diagnosis.
• Offers a combination of clinical and pathological experience for a unique perspective on a complex and difficult area of diagnosis.
• Addresses the "knowledge explosion" over the last 10 years in the fields of molecular genetics and immunocytochemistry, including all of the latest clinically relevant investigative techniques.
• Focuses on diagnostic techniques and on the diagnostic interpretation of results, giving you a portable reference book and a bench book in a single volume.

• Presents all the latest techniques in molecular diagnosis and immunocytochemistry as they apply to individual disorders.
• Includes high-quality, full-color illustrations throughout the book.
• Incorporates tables, summary charts, and boxes to provide a user-friendly, accessible format.

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Editorial Reviews

Doody's Review Service
Reviewer: Ivan Damjanov, MD (University of Kansas Medical Center)
Description: This is the third edition of the well known, very popular, and widely used book on the interpretation of muscle biopsies.
Purpose: The authors' main purpose was to update the 1985 (second) edition of their book, which first appeared in print in 1973. Their efforts have paid off and they have produced a very nice book.
Audience: This was written for neurologists and pathologists who perform, examine, or interpret muscle biopsies. It will be used by residents as well. The authors are well known for their work on muscle diseases. A book by these experts will undoubtedly be received with great enthusiasm by all those who deal with muscle diseases. A lot of personal experience has been distilled into these well-worded pages!
Features: This is a compact book divided into two sections. Section 1 deals with the technical aspects of muscle biopsy, and includes step-by-step instructions on how to prepare the muscle for complex studies in the pathology laboratory. It also includes a review of normal muscle histology and essential elements of electron microscopy, enzyme histochemistry and immunohistochemistry. At the end of this section, there is a very useful summary, "How to read the muscle biopsy" that also contains a list of most important muscle diseases. The second section describes the pathology of individual diseases, presented succinctly but comprehensively.
Assessment: This is a major revision of a book that Professor Dubowitz launched more than 30 years ago. Unquestionably, this is an outstanding, beautifully produced book that provides readers with almost all they need to know about muscle biopsy. Well written, emphasizing the most important aspects of etiology, pathogenesis, and pathology, the book could be used as a primer as well as a reference for expert consultation. In other words, it is ideally suited for novices and experts in the field. It is profusely illustrated with high quality color illustrations, electron microphotographs, and schematic drawings that enhance the text. The references are current and include many 2004 articles. This is a much needed manual, which will, I hope, be as popular as its predecessors. It is, in my opinion, the best medium-sized book of muscle pathology currently in print. It belongs to the set of core titles in all pathology/neurology departmental libraries. It also deserves to be in all comprehensive hospital and medical school libraries.
From the Publisher
"The third edition of this book...has surpassed my expectations. The quality of the book overall is excellent, from the production and layout to the illustrations, diagrams and index. The range of muscle diseases included spans both adults and children, with an integrated approach to diagnosis including clinical, genetic, biochemical and pathological features. Overall, this book has been a highlight of the past year for me. It deserves to do very well indeed and will be of immense value beyond its target readership." BMA Awards 2007
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Product Details

  • ISBN-13: 9781416025931
  • Publisher: Elsevier Health Sciences
  • Publication date: 10/16/2006
  • Edition description: New Edition
  • Edition number: 3
  • Pages: 626
  • Product dimensions: 7.70 (w) x 9.80 (h) x 1.40 (d)

Table of Contents

Section 1 The Biopsy: Normal and Diseased Muscle

1. The procedure of muscle biopsy

2. Histological and histochemical stains and reactions

3. Normal muscle

4. Definition of pathological changes seen in muscle biopsies

5. Ultrastructural changes in diseased muscle

6. Immunohistochemistry

7. How to read a biopsy

Section 2 Pathological Muscle: Individual Diseases

8. Classification of neuromuscular disorders

9. Neurogenic disorders

10. Muscular dystrophies and allied disorders I: Duchenne and Becker muscular dystrophy

11. Muscular dystrophies and allied disorders II: limb-girdle muscular dystrophies

12. Muscular dystrophies and allied disorders III: congenital muscular dystrophies

13. Muscular dystrophies and allied disorders IV: Emeryƒ{Driefuss muscular dystrophies and Bethlem myopathy

14. Muscular dystrophies and allied disorders V: facioscapulohumeral dystrophy, myotonic dystrophy, oculopharyngeal muscular dystrophy

15. Congenital myopathies

16. Myofibrillar myopathies

17. Metabolic myopathies I: glycogenoses

18. Metabolic myopathies II: lipid related disorders and mitochondrial myopathies

19. Endocrine disorders

20. Ion channel disorders

21. Myasthenic syndromes

22. Inflammatory myopathies

23. Toxic and drug-induced myopathies
Russell Lane, Charing Cross Hospital

Appendix 1. Glossary of commonly used terms



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