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Doody's Review ServiceReviewer: Matthew J Brady, Ph.D.(University of Chicago Medical Center)
Description: "This book, part of the Frontiers in Animal Diabetes Research series, provides a timely and comprehensive overview of the regulation of energy uptake and utilization in muscle from normal and diabetic models. The chapters are written by leaders in their respective fields, and provides an excellent review for a wide range of researchers, from graduate students entering the area to more established investigators wishing to attain a comprehensive overview of this rapidly moving research field. "
Purpose: The purpose is to examine the mechanisms by which insulin resistance develops in skeletal muscle. Since a defect in insulin-stimulated glucose uptake and disposal in skeletal muscle precedes the development of type II diabetes, it is imperative to understand the underlying causes of insulin resistance. The editors have successfully assembled a panel of researchers employing a wide variety of techniques to investigate this subject.
Audience: The chapters are written in a very clear and straightforward manner, making them suitable for graduate students. However, the material is of suitable complexity to make it of interest to more advanced PhD and MD researchers.
Features: A particular strength of this book is the logical organization and progression of subject matter. After reviewing basic features of insulin signaling and glucose transport in skeletal muscle, the book progresses to a more in-depth analysis on how inappropriate substrate utilization may result in the development of insulin resistance. This work is then extended into a series of chapters on both animal and human models of insulin resistance and type II diabetes. The only weakness of the book is the omission of current therapeutic strategies for treating insulin resistance.
Assessment: This book is an excellent resource for any researcher working in the areas of insulin signaling, skeletal muscle metabolism and insulin resistance/type II diabetes. The articles are uniformly clear and informative, with strong figures highlighting important research findings and excellent references for further reading.