Description: This succinct and remarkable book on muscular dystrophies reflects the latest expert opinions and a major development in our understanding of these heterogeneous disorders, hopefully laying the foundation for future successful therapies.
Purpose: The purpose is to present a summary of what we know and new insights into these disorders with an emphasis on advances in molecular and cell biology, biochemistry, and other biological sciences and their clinical implications as well as their relevance to the diagnosis and management of patients. These important and worthy objectives are expertly met in this book, part of the Handbook of Clinical Neurology series.
Audience: The editors have assembled an impressive international group of renowned neuromuscular experts to write this book. Although it targets basic investigators and clinicians in general, it will benefit neuromuscular specialists, neurologists, neurology residents, and fellows the most.
Features: Taking into account the dilemma of the ingrained terminology and incompleteness of traditional classifications based on age of onset, mode of inheritance, and pattern of weakness for these disorders, the authors include the nomenclature stemming from the genetic defect such as dystrophinopathies, sarcoglycanopathies, the collagen VI-related myopathies, dysferlinopathies, caveolinopathies, etc. Chapters provide cogent summaries of each of these muscular dystrophy subtypes with sections that highlight a logical approach that includes information not only on background, epidemiology, pathology, pathophysiology, but also the recommended diagnostic algorithms, management, prognosis, and research, along with hopes for future causative therapies. The tables, diagrams, and figures are well designed, easy to understand, and demonstrate the take-home message with clarity. Although some illustrations are in color, there is room for more of these as they significantly liven up the text and enhance readers' experience.
Assessment: This is a high quality resource for the targeted audience that pays special attention to rapid developments and the latest information in the field of neuromuscular neurology while providing a practical approach to the diagnosis and management of these disorders. It competes well with other books on this topic and, in some areas, surpasses them.