Mycobacterium: Genomics and Molecular Biology

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In this book, expert scientists critically review the current and most recent advances in the genomics and molecular biology of mycobacteria. With the focus being on the topical and most relevant aspects, the contributors provide insight into the current understanding of the subject and the future direction of research. Topics covered include strain variation and evolution, hypervirulent strains, electron transport and respiration, lipid biosynthesis, DNA repair, oxygen signaling, sulphur metabolism, protein secretion, the protein kinase family, and much more. This is a valuable reference text for all microbiology laboratories and is essential reading for all scientists and researchers involved with mycobacteria.
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Editorial Reviews

Doody's Review Service
Reviewer: Rebecca T. Horvat, PhD, D (ABMM)(University of Kansas Medical Center)
Description: This book reviews the research efforts that have emerged over the last few years into the basic nature of mycobacterium, especially Mycobacteria tuberculosis. The information summarized here represents the extensive research into these bacteria and the utility of using this information to fight diseases associated with the pathogens in this group.
Purpose: The authors express the great need to understand the basic mechanisms of the mycobacterium in order to recognize the consequences of bacterial survival and pathogenicity in hosts such as humans. Tuberculosis is still a serious disease in the world and remains a threat to human health. This is important information that may lead to better therapy and prevention.
Audience: Scientists investigating pathogenic bacteria as well as individuals involved in treating and detecting these diseases are the intended audience. The authors of each chapter have extensive expertise in the area of mycobacterial pathogenesis and biochemistry, and all have an ongoing research laboratory that studies these organisms.
Features: The book covers a variety of topics that give insight into the metabolism and evolution that leads to variations of the pathogenic Mycobacterium tuberculosis. Some of these new discoveries may lead to targeted therapies as well as a clearer understanding of pathogenesis. Several chapters discuss the synthesis of the bacterial cell wall and protein secretion. Interesting studies on the metabolism of mycobacterium give insight into the ability of these bacteria to remain dormant in the host for many years. The new understanding of the life cycle of M. tuberculosis would assist in developing drugs that target latent infection as well as active infections. In addition, interesting chapters explain and describe the hypervirulent strains of tuberculosis.
Assessment: This very timely book reviews the current knowledge about the genetics and cell biology of the mycobacterium species. It is clear that this information will lead to new treatment options and preventive strategies that may cure or prevent the serious disease of tuberculosis.
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Product Details

  • ISBN-13: 9781904455400
  • Publisher: Caister Academic Press
  • Publication date: 1/1/2009
  • Pages: 213
  • Product dimensions: 6.90 (w) x 10.00 (h) x 0.60 (d)

Table of Contents

1 Strain Variation and Evolution Sebastien Gagneux Gagneux, Sebastien 1
2 Hypervirulent Mycobacterium tuberculosis Nicola Casali Casali, Nicola 19
3 Electron Transport and Respiration in Mycobacteria Bavesh D. Kana Kana, Bavesh D. Edith E. Machowski Machowski, Edith E. Norman Schechter Schechter, Norman Jiah-Shin Teh Teh, Jiah-Shin Harvey Rubin Rubin, Harvey Valerie Mizrahi Mizrahi, Valerie 35
4 Novel Paradigms of Complex Lipid Biosynthetic Machinery of Mycobacterium tuberculosis Arush Chhabra Chhabra, Arush Rajesh S. Gokhale Gokhale, Rajesh S. 65
5 DNA Repair: Key to Survival? Elaine O. Davis Davis, Elaine O. Lorna N. Forse Forse, Lorna N. 79
6 Oxygen, Nitric Oxide and Carbon Monoxide Signalling Martin I. Voskuil Voskuil, Martin I. Ryan W. Honaker Honaker, Ryan W. Adrie J. C. Steyn Steyn, Adrie J. C. 119
7 Sulphur Metabolism in Mycobacteria Ryan H. Senaratne Senaratne, Ryan H. Kathleen Y. Dunphy Dunphy, Kathleen Y. 149
8 The Eukaryotic-like Serine/Threonine Protein Kinase Family in Mycobacteria Nicole Scherr Scherr, Nicole Jean Pieters Pieters, Jean 171
9 Specialized Protein Secretion Systems of Mycobacteria Wilbert Bitter Bitter, Wilbert Edith N. G. Houben Houben, Edith N. G. Joen Luirink Luirink, Joen 193 Index 211
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