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Myocardial Viability: A Clinical and Scientific Treatise

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Despite remarkable advances in the understanding and management of impaired left ventricular function (LVF) and related coronary disease, the prevalence of heart failure in the U.S. and the resulting death rates have almost tripled in the past 3 decades. New understanding of the relationships between the myocardium and LVF demonstrate a direct correlation between myocardial viability and improved patient survival. Because of this, myocardial viability is now a major investigative area in contemporary cardiology, ...
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Overview

Despite remarkable advances in the understanding and management of impaired left ventricular function (LVF) and related coronary disease, the prevalence of heart failure in the U.S. and the resulting death rates have almost tripled in the past 3 decades. New understanding of the relationships between the myocardium and LVF demonstrate a direct correlation between myocardial viability and improved patient survival. Because of this, myocardial viability is now a major investigative area in contemporary cardiology, one that holds significant clinical and prognostic relevance.

Authored by physicians of international renown, the book brings together various disciplines affecting myocardial viability, with five main sections providing an introduction and comprehensive review of: basic concepts and mechanisms; vascular biology and cellular physiology; advances in functional imaging; and perfusion, metabolism and cell membrane integrity. New concepts, such as stunning and hibernation, are clarified, and subsequent novel diagnostic and therapeutic strategies are described. New and sophisticated examination techniques are also presented, as well as advances in instrumentation and imaging techniques, which may result in improved use of resources and enhanced efficiency of health care delivery.

This monograph will serve as a reference source for those interested in the field of myocardial viability, and hopefully improve understanding between investigators from various disciplines. Clinical cardiologists, physicians, and nurses in the field, as well as radiologists, vascular surgeons, reperfusionists, cellular biologists and physiologists, and students will all find material of interest inthis book.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: John F. Moran, MD (Loyola University Stritch School of Medicine)
Description: This is a multiauthored text on the detection of viable myocardium that may be stunned or hibernating and responsive to revascularization.
Purpose: The purpose is to bring basic cellular physiology and clinical decision making together in a focus on myocardial viability. The editor and contributors succeed in their objectives.
Audience: The book is directed to the clinician scientist and all students of physiology and metabolism whether they are radiologists or cardiologists. There is much good information here to do background for research projects in this area.
Features: The monograph contains 18 chapters divided into five areas. Each chapter comes with an extensive list of references. Ischemic cellular physiology, clinical issues, and diagnostics are well discussed. Echo, SPECT, PET, and MRI scanning techniques are all covered well. From a basic science viewpoint, the ischemic effects of nitric oxide, cellular energy cycles, and cellular channels are discussed. There is a particularly good section on thallium and myoview scans.
Assessment: With this monograph the editor brings much information on myocardial viability together into one place. The basic and clinical aspects of stunned and hibernating myocardium are important to clinical decision making about revascularization. These are important clinical topics and all the answers are not available. This text is a good start for interested professionals.
John F. Moran
This is a multiauthored text on the detection of viable myocardium that may be stunned or hibernating and responsive to revascularization. The purpose is to bring basic cellular physiology and clinical decision making together in a focus on myocardial viability. The editor and contributors succeed in their objectives. The book is directed to the clinician scientist and all students of physiology and metabolism whether they are radiologists or cardiologists. There is much good information here to do background for research projects in this area. The monograph contains 18 chapters divided into five areas. Each chapter comes with an extensive list of references. Ischemic cellular physiology, clinical issues, and diagnostics are well discussed. Echo, SPECT, PET, and MRI scanning techniques are all covered well. From a basic science viewpoint, the ischemic effects of nitric oxide, cellular energy cycles, and cellular channels are discussed. There is a particularly good section on thallium and myoview scans. With this monograph the editor brings much information on myocardial viability together into one place. The basic and clinical aspects of stunned and hibernating myocardium are important to clinical decision making about revascularization. These are important clinical topics and all the answers are not available. This text is a good start for interested professionals.
Booknews
Brings together material from various disciplines affecting myocardial viability, with five main sections providing an introduction and comprehensive review of basic concepts and mechanisms, vascular biology and cellular physiology, advances in functional imaging, and perfusion, metabolism, and cell membrane integrity. Concepts such as stunning, hibernation, and preconditioning are clarified, and subsequent novel diagnostic and therapeutic strategies are described. New examinations as well as advances in instrumentation and imaging techniques are presented. The editor is director of nuclear cardiology at the National Institutes of Health. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780879934378
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 1/28/2000
  • Edition number: 1
  • Pages: 448

Table of Contents

Contributors
Preface
Pt. I Introduction
Ch. 1 Perspectives on the Study of Human Myocardium: Viability 3
Pt. II Basic Concepts and Mechanisms
Ch. 2 Modulation of Responses to Myocardial Ischemia: Metabolic Features of Myocardial Stunning, Hibernation, and Ischemic Preconditioning 25
Ch. 3 Reversible Myocardial Dysfunction: Stunning, Hibernation, or What? 37
Ch. 4 Preconditioning 55
Pt. III Vascular Biology and Cellular Physiology
Ch. 5 Experimental Models Useful in Evaluating Myocardial Viability 79
Ch. 6 Essential Fuels for the Heart and Mechanical Restitution 91
Ch. 7 Nitric Oxide and Energetics of the Heart: Physiology and Pathophysiology 105
Ch. 8 Channels, Ischemia, and Stunning: Cellular Electrophysiology and Intercellular Communication 115
Pt. IV Advances in Functional Imaging
Ch. 9 New Methods for Measurement of Regional and Global Ventricular Function 163
Ch. 10 Myocardial Contractile Reserve 181
Ch. 11 Morphological and Echocardiographic Features of Viable and Nonviable Myocardium 207
Ch. 12 Timing and Myocardial Salvage: Lessons Learned From the Thrombolytic and Revascularization Multicenter Trials 233
Pt. V Perfusion, Metabolism, and Cell Membrane Integrity
Ch. 13 Introduction to Tracer Kinetics 251
Ch. 14 Thallium-201 Scintigraphy: Experience of Two Decades 265
Ch. 15 Technetium-99m - Labeled Myocardial Perfusion Tracers: Blood Flow or Viability Agents? 315
Ch. 16 Myocardial Imaging of Lipid Metabolism with Labeled Fatty Acids 349
Ch. 17 Positron Emission Tomography for the Assessment of Myocardial Viability: Noninvasive Approach to Cardiac Pathophysiology 391
Ch. 18 Nuclear Magnetic Resonance and Myocardial Viability 419
Index 437
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