Myologyby Andrew G. Engel, Clara Franzini-Armstrong
The most reliable and comprehensive resource on the topic of muscle diseases and disorders. An extraordinary amount of new information has entered the field of myology since the publication of the first edition of Myology in 1986 - primarily as a result of advances in molecular biology. The second edition contains over 50% new and revised material,including important information on muscular dystrophy and inflammatory disease,as well as a better understanding of mitochondrial diseases and the genetic basis of inherited diseases.
Description: Myology has long been considered to be the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a substantial update from the second edition in 1994 and reflects the clinical, pathologic, and molecular biology advances over the past decade. The majority of chapters were revised, entirely rewritten, or are new additions reflecting the molecular biology advances in our understanding of muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle protein.
Purpose: The new edition of Myology fulfilled the editors' objective to provide a comprehensive review of muscle biology and skeletal muscle disease.
Audience: The editors brought together a group of 97 distinguished international authors to contribute and compile this latest edition of Myology. Specific topics are comprehensive with complete and contemporary references cited. This text is an excellent resource for muscle diseases and disorders with utility for students, as well as research and clinical investigators and practitioners in neurology, neuroscience, medicine, and exercise physiology. Specific chapters would be of interest to scientists and clinicians in rheumatology, ophthalmology, and genetics.
Features: This edition is still organized in three parts: scientific basis, general approaches to neuromuscular diseases, and diseases of muscle. Part one was significantly expanded and reorganized based on the extraordinary amount of new molecular biology research defining regulatory pathways, signaling cascades, and cellular mechanisms controlling muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle proteins. New research on the molecular and functional aspects of plasmalemma ion channels and pumps are presented. Scientific advances on muscle activation and control of muscle activity are reviewed. New color plates vividly illustrate how protein configuration and protein-protein interactions control muscle contraction as well as ion channel and pump function. The Diseases of Muscle Section was updated throughout. For example, Limb-Girdle Muscular Dystrophies (LGMD) in 1994 included one dominant and three recessive forms. Now, the 2004 edition presents six dominant and ten recessive forms. This revised chapter benefits from advances in genetics that characterized families within LGMD to refine our definition of the clinical and pathologic differences and similarities of these distinct disorders that all classified as LGMD. Tables in this chapter clarify the large number of abnormal gene defects with their proteins and phenotypic classifications for these muscular dystrophies. Another table outlines specific abnormal proteins associated with LGMD, their phenotypes, and special diagnostic considerations based on specific protein expression. Conceptual models show the complex cellular processes involved in LGMD, including extracellular matrix, plasma membrane and associated proteins, sarcomeric proteins, nuclear envelope, and enzymes that can all result in LGMD. This chapter highlights the normal function of each of these proteins associated with LGMD and outlines physiologic experiments and mutation studies to demonstrate how genetic and protein abnormalities give rise to the specific phenotypic disease manifestations. Finally, this chapter presents clinical presentation of each LGMD, their clinical evaluation and muscle biopsy, protein, and genetic studies. The illustrations in the Diseases of Muscle section complement the text to exemplify specific clinical characteristics, expected electrophysiologic and ancillary diagnostic results, and characteristic findings on muscle biopsy to aid the practitioner in diagnosis.
Assessment: Myology will continue to be considered the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a timely substantial update to the second edition in 1994 and reflects the advances in clinical, pathologic, and molecular biology over the past decade.
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Meet the Author
Andrew G. Engel
Professor of Neurology
William M. McKnight 3M Professor
Dr. Engel is widely regarded as the world authority on Muscle disease.
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