Myology / Edition 3

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2004 Hardcover Good 017 Item may show signs of shelf wear. Pages may include limited notes and highlighting. Includes supplemental or companion materials if applicable. Access ... codes may or may not work. Connecting readers since 1972. Customer service is our top priority. Read more Show Less

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Overview

The most comprehensive reference on neuromuscular diseases and disorders!

A Doody's Core Title

5 STAR DOODY'S REVIEW!

"This text is an excellent resource for muscle diseases and disorders with utility for students, as well as research and clinical investigators and practitioners in neurology, neuroscience, medicine, and exercise physiology....Myology will continue to be considered the most reliable and comprehensive resource on the topic of muscle diseases and disorders."—Doody's Review Service

Edited by the world’s leading authority, this is the reference of choice for neurologists who a need a complete, authoritative work on muscle diseases and disorders. Features over 100 color illustrations of clinical, pathological, and imaging studies in myology. Includes important information on muscular dystrophy and inflammatory disease as well as a better understanding of mitochondrial diseases and the genetic basis of inherited diseases.

"...important advances in the cellular and molecular understanding of muscular disorders have precipitated the wealth of new information presented here on such sujbects as muscular dystrophy, inflammation, mitochondrial disease,etc.

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Editorial Reviews

Doody's Review Service
Reviewer: Charlene Hafer-Macko, MD (University of Maryland School of Medicine)
Description: Myology has long been considered to be the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a substantial update from the second edition in 1994 and reflects the clinical, pathologic, and molecular biology advances over the past decade. The majority of chapters were revised, entirely rewritten, or are new additions reflecting the molecular biology advances in our understanding of muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle protein.
Purpose: The new edition of Myology fulfilled the editors' objective to provide a comprehensive review of muscle biology and skeletal muscle disease.
Audience: The editors brought together a group of 97 distinguished international authors to contribute and compile this latest edition of Myology. Specific topics are comprehensive with complete and contemporary references cited. This text is an excellent resource for muscle diseases and disorders with utility for students, as well as research and clinical investigators and practitioners in neurology, neuroscience, medicine, and exercise physiology. Specific chapters would be of interest to scientists and clinicians in rheumatology, ophthalmology, and genetics.
Features: This edition is still organized in three parts: scientific basis, general approaches to neuromuscular diseases, and diseases of muscle. Part one was significantly expanded and reorganized based on the extraordinary amount of new molecular biology research defining regulatory pathways, signaling cascades, and cellular mechanisms controlling muscle development and differentiation. It incorporates knowledge from recent genetic studies that delineate the clinical and pathologic relevance of the newly described contractile, metabolic, and regulatory skeletal muscle proteins. New research on the molecular and functional aspects of plasmalemma ion channels and pumps are presented. Scientific advances on muscle activation and control of muscle activity are reviewed. New color plates vividly illustrate how protein configuration and protein-protein interactions control muscle contraction as well as ion channel and pump function. The Diseases of Muscle Section was updated throughout. For example, Limb-Girdle Muscular Dystrophies (LGMD) in 1994 included one dominant and three recessive forms. Now, the 2004 edition presents six dominant and ten recessive forms. This revised chapter benefits from advances in genetics that characterized families within LGMD to refine our definition of the clinical and pathologic differences and similarities of these distinct disorders that all classified as LGMD. Tables in this chapter clarify the large number of abnormal gene defects with their proteins and phenotypic classifications for these muscular dystrophies. Another table outlines specific abnormal proteins associated with LGMD, their phenotypes, and special diagnostic considerations based on specific protein expression. Conceptual models show the complex cellular processes involved in LGMD, including extracellular matrix, plasma membrane and associated proteins, sarcomeric proteins, nuclear envelope, and enzymes that can all result in LGMD. This chapter highlights the normal function of each of these proteins associated with LGMD and outlines physiologic experiments and mutation studies to demonstrate how genetic and protein abnormalities give rise to the specific phenotypic disease manifestations. Finally, this chapter presents clinical presentation of each LGMD, their clinical evaluation and muscle biopsy, protein, and genetic studies. The illustrations in the Diseases of Muscle section complement the text to exemplify specific clinical characteristics, expected electrophysiologic and ancillary diagnostic results, and characteristic findings on muscle biopsy to aid the practitioner in diagnosis.
Assessment: Myology will continue to be considered the most reliable and comprehensive resource on the topic of muscle diseases and disorders. This third edition represents a timely substantial update to the second edition in 1994 and reflects the advances in clinical, pathologic, and molecular biology over the past decade.

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780071371803
  • Publisher: McGraw-Hill Companies, The
  • Publication date: 4/30/2004
  • Edition description: REV
  • Edition number: 3
  • Pages: 1800
  • Product dimensions: 8.80 (w) x 11.20 (h) x 3.75 (d)

Meet the Author

Andrew G. Engel

Professor of Neurology

William M. McKnight 3M Professor

Dr. Engel is widely regarded as the world authority on Muscle disease.

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Table of Contents

1 Embryonic origins of skeletal muscles 3
2 Assembly of the skeletal muscle cell 45
3 Satellite and stem cells in muscle regeneration 66
4 The diversity of muscle fiber types and its origin during development 87
5 The structure and function of motor units 104
6 Extraocular muscles 119
7 Molecular structure of the sarcomere 129
8 Mammalian muscle myosin 167
9 Molecular physiology of the cross-bridge cycle 187
10 Ion channels and electrical properties of skeletal muscle 203
11 The membrane systems of muscle cells 232
12 Excitation-contraction coupling in skeletal muscle 257
13 Activation of the contractile mechanism by calcium 281
14 The proteins of the sarcotubular system 307
15 The neuromuscular junction 325
16 Neuromuscular transmission 373
17 Nicotinic acetylcholine receptors : structure, function, and antigenicity 397
18 Function and molecular structure of acetylcholinesterase 423
19a The cytoskeleton : maintenance of muscle fiber integrity 443
19b The muscle fiber cytoskeleton : the dystrophin system 455
20 The extracellular matrix 471
21 The muscle spindle 489
22 Microcirculation in muscle 511
23 Protein and amino acid metabolism in muscle 535
24 Lysosomal metabolism and its relevance to skeletal muscle 565
25 The clinical examination 599
26 Electrodiagnosis of muscle disorders 619
27 Muscle imaging 655
28 Functional evaluation of metabolic myopathies 665
29 The muscle biopsy 681
30 Basic reactions of muscle 691
31 Ultrastructural changes in diseased muscle 749
32 Immune mechanisms in muscle diseases 889
33 The tools of molecular genetics and their application to the study of muscle diseases 915
34 Dystrophinopathies 961
35 Emery-dreifuss muscular dystrophy 1027
36 Myotonic dystrophy 1039
37 The limb-girdle muscular dystrophies 1077
38 Facioscapulohumeral muscular dystrophy and scapuloperoneal disorders 1123
39 Bethlem myopathy 1135
40 Oculopharyngeal muscular dystrophy 1147
41 X-linked vacuolar myopathies 1163
42 Distal myopathies 1169
43 Myofibrillar myopathies 1187
44 The congenital muscular dystrophies 1203
45 Cardiomyopathies associated with muscular dystrophies 1239
46 Nondystrophic myotonias and periodic paralyses 1257
47 Generalized peripheral nerve hyperexcitability (neuromyotonia) 1301
48 Hereditary inclusion body myopathies 1311
49 The polymyositis and dermatomyositis syndromes 1321
50 Inclusion body myositis 1367
51 Virus-related muscle diseases 1389
52 Parasitic myositis 1419
53 Other inflammatory myopathies 1445
54 Congenital myopathies 1473
55 Nonlysosomal glycogenoses 1535
56 Acid maltase deficiency 1559
57 Disorders of lipid metabolism 1587
58 Mitochondrial encephalomyopathies 1623
59 Malignant hyperthermia 1663
60 Myoglobinura 1677
61 Myopathies due to drugs, toxins, and nutritional deficiency 1693
62 Endocrine myopathies 1713
63 Muscle pain, cramps, and fatigue 1739
64 Acquired autoimmune myasthenia gravis 1755
65 The Lambert-Eaton myasthenic syndrome 1791
66 Congenital myasthenic syndromes 1801
67 Spinal muscular atrophies 1845
68 Adult and juvenile amyotrophic lateral sclerosis and related motor neuron diseases 1865
69 Disease of peripheral nerves 1889
70 Congenital deformities 1931
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