Myosins / Edition 2

by James R. Sellers

Overview

The term myosin refers to a diverse superfamily of molecular motors that are capable of either translocating actin filaments or of translocating vesicles or other cargo on fixed actin filaments. There are currently 15 distinct classes in the superfamily, and this book provides complete and up-to-date information on all of them. Since the publication of the first edition in 1995, a large amount of information has been printed about myosin, including the link of mutations in myosin to three human diseases. Myosin examines this new information in conjunction with helpful data provided by new techniques such as molecular imaging. This thoroughly revised edition is ideal for post-graduates and researchers in biochemistry, cell biology, molecular biology, and medicine who are seeking the latest information on the myosin superfamily of proteins.

Product Details

ISBN-13:	9780198505099
Publisher:	Oxford University Press
Publication date:	07/29/1999
Series:	Protein Profiles
Edition description:	REV
Pages:	252
Product dimensions:	7.30(w) x 9.50(h) x 0.50(d)

About the Author

Laboratory of Molecular Cardiology, National Heart, Lung and Blood Institute, National Institutes of Health, MD

Table of Contents

AcknowledgementsAbbreviationsIntroductionMyosin structureFunctional properties of myosinCovalent derivatization of myosinRegulationMyosin binding proteinsMutations in myosinBibliographySequence alignmentList of figuresList of tables

Editorial Reviews

"The myosins are a diverse superfamily of molecular motor proteins that share the ability to reversibly bind actin and hydrolyze MgATP. Sellers (molecular cardiology, US National Institutes of Health) explores their structure and functional properties, their regulation, and mutational analysis. The 1995 edition has been updated with three additional classes defined by new sequences, information from the crystal structure of seven new Dicytostelium motor domains and three new smooth muscle myosin heads, and data from new techniques such as molecular imaging and tagging proteins with GFP. It includes a glossary of nearly 3,000 references . . ."—SciTech Book News

From the Publisher

The myosins are a divers superfamily of molecular motor proteins that share the ability to reversibly bind actin and hydrolyze MgATP. Sellers (molecular cardiology, US National Institutes of Health) explores their structure and functional properties, their regulation, and mutational analysis. The 1995 edition has been updated with three additional classes defined by new sequences, information from the crystal structure of seven new motor domains and three new smooth muscle myosin heads, and data from new techniques such as molecular imaging and tagging proteins with GFP. It includes a glossary of nearly 3,000 references, but no index. Annotation c. Book News, Inc., Portland, OR (booknews.com)

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