Gift Guide

Nanoscale and bulk temperature measurements in RF heated nanoparticle systems.

More About This Textbook


Thermal therapies employing nanoparticles generating heat in the presence of alternating electromagnetic field are of high interest to medical community. Currently, therapies employing nanoparticle heating are being investigated on two fronts: (1) they are explored for controlling processes at molecular level; and (2) they are used to produce necrosis in a relatively large biological mass such as a tumor.;Remote heating of nanoparticles for inducing a selective transformation at the molecular/nanoscale level has been proposed relative recently. A series of recent literature reports suggest that nanoparticles are able to produce locally a temperature rise of several degrees above the "bulk" value. However, theoretical predictions based on macroscale heat diffusion theories do not validate these experimental findings. To resolve this apparent disagreement between theory and experimental data, measurement of local temperature rise in the proximity of heated nanoparticles is needed.;This work presents temperature measurements in the vicinity of gold and magnetite nanoparticles suspended in solutions and remotely heated by radio frequency (RF) electromagnetic field. Core-shell semiconductor CdSe quantum dots passivated with a layer of ZnS are used as local temperature sensors. Their temperature is inferred from the shift in the peak of fluorescent emission of the quantum dots. To determine the difference between local and "bulk" temperature, measurements are carried out on two sets of samples: control solutions and conjugated specimens. In the control solutions, the quantum dots are mixed with nanoparticles. Hence, the quantum dots are free to move and they measure an average or "bulk" temperature rise of the sample. In conjugated specimens, the quantum dots are covalently linked to the nanoparticles. Since the distance between covalently bonded quantum dot and nanoparticle is of a few nanometers, they measure the local temperature rise in the proximity of nanoparticle. Both mixed and conjugated specimens have low nanoparticle concentrations, to minimize the heating effect on quantum dots from non-bonded particles in conjugated specimens. From these experiments it is found that measured bulk and local temperature differ by less than 1°C, which is comparable to the experimental error. This suggests that the local heating is negligible, at least for the experimental conditions employed in this work.;While measurements of local temperature rise are important to fundamental understanding of heat transfer in bio-conjugated nano-systems, accurate quantification of "bulk" heating of RF heated nanoparticles is critical for applications such as cancer hyperthermia. The second part of this thesis analyzes the experimental method used to determine the heat generation rate (or specific absorption rate---SAR) of nanoparticles and identifies potential shortcomings associated with the experimental setup and data reduction procedure. While SAR is typically determined from the initial slope of the temperature rise of nanoparticles suspension as function of time, the experimental setups and data reduction techniques vary widely in literature. In many of the SAR installations reported, the coil is directly wounded around the container holding the test solution. Since the magnetic field varies along the radius and the axis of the coil, this configuration may lead to errors associated with non-uniform heat generation. Moreover, since SAR is determined from the transient temperature rise of the sample, it can be affected by the heat capacity of the container. Finally, the data reduction procedure which is often based on polynomial fitting, may also affect the accuracy of reported SAR. All these aspects are illustrated by finite element modeling simulations. In addition to finite element modeling, experiments are also carried out to demonstrate the effect of container heat capacity.
Read More Show Less

Product Details

  • ISBN-13: 9781109683912
  • Publisher: ProQuest LLC
  • Sold by: Barnes & Noble
  • Format: eTextbook
  • Pages: 149
  • File size: 19 MB
  • Note: This product may take a few minutes to download.

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)