Nanotechnology in Cancer Therapeutics

Nanotechnology in Cancer Therapeutics

by Mansoor M. Amiji

ISBN-10: 0849371945

ISBN-13: 9780849371943

Pub. Date: 11/15/2006

Publisher: Taylor & Francis

While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance for Nanotechnology


While simultaneous breakthroughs occurring in molecular biology and nanoscience/technology will ultimately revolutionize all of medicine, it is with our efforts to prevent, diagnose, and treat cancer that many of the most dramatic advances will occur. In support of this potential, the U.S. National Cancer Institute (NCI) established the Alliance for Nanotechnology in Cancer in 2004 and pledged $144.3 million in funding over the next five years.

Edited by one of the most dynamic pioneers in the field, Nanotechnology for Cancer Therapy focuses on those nanoscientific and nanotechnological strategies that are evolving as the most promising for the imaging and treatment of cancer. Among the various approaches considered, nanotechnology offers great possibilities for the targeted delivery of drugs and genes to tumor sites and the ultimate replacement of those chemotherapeutic agents so compromised by side effects.

Within this volume, the expertise of world-renowned academic and industrial researchers is brought together to provide a comprehensive treatise. Composed of 38 chapters, the book is divided into 7 sections that cover -

  • Fundamentals of targeting strategies, nanotechnology characterization for cancer therapy, and USFDA guidelines on approval of nanotechnology products
  • Polymeric conjugates used for tumor-targeted imaging and delivery, including imaging to evaluate therapeutic efficacy
  • Polymeric nanoparticle systems that emphasize biodegradable, long-circulating nanoparticles for passive and active targeting
  • Polymeric micellar assemblies, where sophisticated chemistry is leading to novel nanosystems that can provide efficient delivery to tumors
  • Dendritic nanostructures used for cancer imaging and therapy
  • Liposome-based delivery systems — the oldest nanotechnology method employed in cancer therapy
  • Other lipid nanosystems used for targeted delivery, including those that can cross biological barriers, as well as mitochondria-specific delivery
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    Table of Contents

    Introduction and Rationale for Nanotechnology in Cancer Therapy; Fredika M. Robertson and Mauro Ferrari
    Passive Targeting of Solid Tumors: Pathophysiological Principles and Physicochemical Aspects of Delivery Systems; S. M. Moghimi
    Active Targeting Strategies in Cancer with a Focus on Potential Nanotechnology Applications; Randall J. Mrsny
    Pharmacokinetics of Nanocarrier-Mediated Drug and Gene Delivery; Yuriko Higuchi, Shigeru Kawakami, and Mitsuru Hashida
    Multifunctional Nanoparticles for Cancer Therapy; Todd J. Harris, Geoffrey von Maltzahn, and Sangeeta N. Bhatia
    Neutron Capture Therapy of Cancer: Nanoparticles and High Molecular Weight Boron Delivery Agents; Gong Wu, Rolf F. Barth, Weilian Yang, Robert J. Lee, Werner Tjarks, Marina V. Backer, and Joseph M. Backer
    Preclinical Characterization of Engineered Nanoparticles Intended for Cancer Therapeutics; Anil K. Patri, Marina A. Dobrovolskaia, Stephan T. Stern, and Scott E. McNeil
    Nanotechnology: Regulatory Perspective for Drug Development in Cancer Therapeutics; N. Sadrieh and T. J. Miller
    Polymeric Conjugates for Angiogenesis Targeted Tumor Imaging and Therapy; Amitava Mitra, Anjan Nan, Bruce R. Line, and Hamidreza Ghandehari
    Poly (L-Glutamic Acid): Efficient Carrier of Cancer Therapeutics and Diagnostics; Guodong Zhang, Edward F. Jackson, Sidney Wallace, and Chun Li
    Noninvasive Visualization of In Vivo Drug Delivery of Paramagnetic Polymer Conjugates with MRI; Zheng-Rong Lu, Yanli Wang, Furong Ye, Anagha Vaidya, and Eun-Kee Jeong
    Polymeric Nanoparticles for Tumor-Targeted Drug Delivery; Tania Betancourt, Amber Doiron, and Lisa Brannon-Peppas
    Long-Circulating Polymeric Nanoparticles for Drug and Gene Delivery to Tumors; Sushma Kommareddy, Dinesh B. Shenoy, and Mansoor M. Amiji
    Biodegradable PLGA/PLA Nanoparticles for Anticancer Therapy; Sanjeeb K. Sahoo and Vinod Labhasetwar
    Poly (alkyl cyanoacrylate) Nanoparticles for Delivery of Anticancer Drugs; R. S. R. Murthy and L. Harivardhan Reddy
    Aptamers and Cancer Nanotechnology; Omid C. Farokhzad, Sangyong Jon, and Robert Langer
    Polymeric Micelles for Formulation of Anticancer Drugs; Helen Lee, Patrick Lim Soo, Jubo Liu, Maok Butler, and Christine Allen
    PEO-Modified Poly (L-Amino Acid) Micelles for Drug Delivery; Afsaneh Lavasanifar, Xiuo-Bing Xiong, and Hamidreza Montazeri Aliabadi
    Hydrotropic Polymer Micelles for Cancer Therapeutics; Sang Cheon Lee, Kang Moo Huh, Tooru Ooy, and Kinam Park
    Tumor-Targeted Delivery of Sparingly-Soluble Anti-Cancer Drugs with Polymeric Lipid-Core Immunomicelles; Vladimir P. Torchilin
    Combined Cancer Therapy by Micellar-Encapsulated Drug and Ultrasound; Natalya Rapoport
    Polymeric Micelles Targeting Tumor pH3; Eun Seong Lee and You Han Bae
    cRGD-Encoded, MRI-Visible Polymeric Micelles for Tumor-Targeted Drug Delivery; Jinming Gao, Norased Nasongkla, and Chalermchai Khemtong
    Targeted Antisense Oligonucleotide Micellar Delivery Systems; Ji Hoon Jeong, Sun Hwa Kim, and Tae Gwan Park
    Dendrimers as Drug and Gene Delivery Systems; Tae-Il Kim and Jong-Sang Park
    Dendritic Nanostructures for Cancer Therapy; Ashootosh V. Ambade, Elamprakash N. Savariar, and S. Thai Thayumanavan
    PEGylated Dendritic Nanoparticulate Carriers of Anti-Cancer Drug; D. Bhadra, S. Bhadra, and N. K. Jain
    Dendrimer Nanocomposites for Cancer Therapy; Lajos P. Balogh and Mohamed K. Khan
    Applications of Liposomal Drug Delivery Systems to Cancer Therapy; Alberto A. Gabizon
    Positively-Charged Liposomes for Targeting Tumor Vasculature; Robert B. Campbell
    Cell Penetrating Peptide (CPP)-Modified Liposomal Nanocarriers for Intracellular Drug and Gene Delivery; Vladimir P. Torchilin
    RGD-Modified Liposomes for Tumor Targeting; S. P. Vyas
    Folate Receptor-Targeted Liposomes for Cancer Therapy; Xiaobin B. Zhao, Natarajan Muthusamy, John C. Byrd, and Robert J. Lee
    Nanoscale Drug Delivery Vehicles for Solid Tumors: A New Paradigm for Localized Drug Delivery Using Temperature Sensitive Liposomes; David Needham and Ana Ponce
    Nanoemulsions Formulations for Tumor-Targeted Delivery; Sandip B. Tiwari and Mansoor M. Amiji
    Solid Lipid Nanoparticles for Antitumor Drug Delivery; Ho Lun Wong, Yongqiang Li, Reina Bendayan, Mike Andrew Rauth, and Xiao Yu Wu
    Lipoprotein Nanoparticles as Delivery Vehicles for Anti-Cancer Agents; Andras G. Lacko, Maya Nair, and Watter J. McConathy
    DQAsomes as Mitochondria-Targeted Nano-Carriers for Anticancer Drugs; Shing-Ming Cheng, Sarathi V. Boddapati, Gerard G. M. D'Souza, and Volkmar Weissig

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