Natural Product Chemistry for Drug Discovery

Overview

Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products. The authors, all experts in their respective fields, provide compelling arguments as to why naturel products should be considered important tools in the drug discovery process. The book will appeal across the board from scientists to ...

See more details below
Hardcover
$220.51
BN.com price
(Save 4%)$232.00 List Price
Other sellers (Hardcover)
  • All (4) from $194.38   
  • New (4) from $194.38   
Sending request ...

Overview

Natural Product Chemistry for Drug Discovery provides a comprehensive summary of where natural product chemistry is today in drug discovery. The book covers emerging technologies and case studies and is a source of up-to-date information on the topical subject of natural products. The authors, all experts in their respective fields, provide compelling arguments as to why naturel products should be considered important tools in the drug discovery process. The book will appeal across the board from scientists to professionals, postgraduates and industrial chemists. The case studies selected for inclusion highlight recently marketed drugs and development candidates that have been derived from natural products. These 'real-life' examples show how new technologies, such as advances in screening, isolation, dereplication and prefractionation, have significantly enhanced the discovery process.

Read More Show Less

Editorial Reviews

Journal of Medicinal Chemistry
"This volume serves as a useful reminder that even as the first decade of the 21st century comes to a close, natural products are still a valuable resource for the new therapeutic agents and new drug leads with broad structural diversity.""This is a timely and highly informative text that belongs in institutional libraries where biomedical research is carried out...many natural product researchers, as well as medicinal chemists, synthetic organic chemists, and pharmacologists will find this volume well worthy of purchase for their personal libraries."
From the Publisher
"This volume serves as a useful reminder that even as the first decade of the 21st century comes to a close, natural products are still a valuable resource for the new therapeutic agents and new drug leads with broad structural diversity." "This is a timely and highly informative text that belongs in institutional libraries where biomedical research is carried out...many natural product researchers, as well as medicinal chemists, synthetic organic chemists, and pharmacologists will find this volume well worthy of purchase for their personal libraries."
Read More Show Less

Product Details

  • ISBN-13: 9780854041930
  • Publisher: Royal Society of Chemistry, The
  • Publication date: 1/28/2010
  • Series: RSC Biomolecular Sciences Series
  • Pages: 458
  • Product dimensions: 6.10 (w) x 9.30 (h) x 1.20 (d)

Meet the Author

Dr A.D. Buss graduated from the Royal Institute of Chemistry before receiving his MSc from the University of East Anglia and then a PhD from the University of Cambridge. He started his career in the pharmaceutical industry with Pfizer before moving to Schering Agrochemicals as a Team Leader. In 1989, he joined Glaxo as Research Manager prior to becoming Head of the Natural Products Discovery Department and, finally, Research Unit Head, Bioprocessing, in 1995. During this period, Dr. Buss served as Chairman of the GlaxoWellcome (UK) Research Management Team and Chairman of the Joint Project Team (combinatorial polyketide biosynthesis) for what was GlaxoWellcome's largest research collaboration with the University of Cambridge. In 2000, he became head of the Centre for Natural Product Research at the Institute of Molecular and Cell Biology in Singapore and, on the Centre's privatisation to MerLion Pharmaceuticals in May 2002, became its President and Chief Executive Officer. Dr Buss is the author or co-author of over fifty peer reviewed scientific publications. Dr Mark S. Butler received his BSc (Hons) and PhD from The University of Melbourne. After postdoctoral work at the Arizona State University, he joined the Queensland Pharmaceutical Research Institute (now Natural Product Research). He then moved to Singapore to lead the Natural Product Chemistry group at the Centre of Natural Product Research (CNPR), which was part of the Institute of Molecular and Cell Biology (IMCB). In 2002, CNPR privatized to become MerLion Pharmaceuticals where his present position is Director of Natural Product Chemistry. He has contributed to over 40 papers on various aspects of natural products chemistry and, in 2002, was awarded the Matt Suffness (Young Investigator) Award by the American Society of Pharmacognosy.

Read More Show Less

Table of Contents

Chapter 1: Natural Products as Drugs and Leads to Drugs: the Historical Perspective; Chapter 2: Chemical Space and the Difference between Natural Products and Synthetics; Chapter 3: The Importance of Mechanism of Action Studies; Chapter 4: The Convention on Biological Diversity and its Impact on Natural Product Research; Chapter 5: Plants: Revamping the Oldest Source of Medicines with Modern Science; Chapter 6: Macromarines: a Selective Account on the Potential of Marine Sponges, Molluscs, Soft Corals and Tunicates as a Source of Therapeutically Important Molecular Structures; Chapter 7: Microorganisms: their Role in the Discovery and Development of Medicines; Chapter 8: Advances in Biological Screening for Lead Discovery; Chapter 9: Advances in Instrumentation and Automation, Dereplication and Prefractionation; Chapter 10: Natural Product Combinatorial Biosynthesis: Promises and Realities; Chapter 11: A Snapshot of Natural Product-Derived Compounds in Late Stage Clinical Development at the End of 2008; Chapter 12: From Natural Product to Clinical Trials: NPI-0052 (Salinosporamide A), a Marine Actinomycete-Derived Anticancer Agent; Chapter 13: From Natural Product to Clinical Trials: Bevirimat, a Plant-Derived Anti-AIDS Drug; Chapter 14: Daptomycin; Chapter 15: Micafungin; Chapter 16: From rapamycin to temsirolimus;

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)