Nelson Textbook of Pediatrics e-dition: Text with Continually Updated Online Reference / Edition 17

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Tap into all of the latest knowledge and expertise in your field ... in print and online! Both a user-friendly printed reference and a fully searchable web site, the e-dition of this classic text gives you two fast ways to find expert solutions to the clinical challenges that arise in your practice. Regular updates online ensure that you'll always have access to the most current information!
  • Equips you with state-of-the-art, evidence-based guidance to help you offer your patients the best possible outcomes.
  • Includes more than 750 outstanding illustrations that show you exactly what to look for and how to proceed.
  • Uses highly structured full-color page layouts inside the printed book to make reference effortless.
  • Offers rapid access to the answers you need via the fully searchable web site.
  • Delivers regular updates online, overseen by the authors, to keep you continually apprised of important new clinical developments.
  • Lets you download all of the book's illustrations for use in electronic presentations.
  • Links references to the corresponding MEDLINE abstracts to simplify further research.

Your purchase entitles you to access the web site until the next edition is published, or until the current edition is no longer offered for sale by Elsevier, whichever occurs first. If the next edition is published less than one year after your purchase, you will be entitled to online access for one year from your date of purchase. Elsevier reserves the right to offer a suitable replacement product (such as a downloadable or CD-ROM-based electronic version) should access to the web site be discontinued.

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Editorial Reviews

From The Critics
Reviewer: Jadranka Popovic, MD (Children's Mercy Hospital)
Description: This is the 17th edition of the multiauthored book of pediatrics. The first edition was published in 1933.
Purpose: As stated by the editors, the book was written to continuously update the knowledge of common and less common diseases and disorders in pediatrics. The objective is to provide a guide to recognition, understanding, diagnosing, and treating problems of pediatric patients in an easy-to-use and readable format. The goal is to be comprehensive, concise, and reader friendly. This book could be used for rapid review in a busy clinical setting or as a textbook for more comprehensive studying.
Audience: "The book is intended for general pediatricians, house staff, medical students, and others involved in pediatric medicine. Although pediatricians will probably be the main users, others might find it very helpful. This book provides adequate information for those needing a quick reference for a practical clinical approach, yet it also provides comprehensive coverage of the field. For more in-depth readings on rare conditions or for extensive subspecialty information, the authors suggest consulting references listed at the end of chapters. "
Features: The book has 33 major parts each divided into sections. Each section is further divided into the chapters for a total of 713 chapters. The book provides extensive and comprehensive coverage of all common and less common diseases and conditions in pediatrics. Each chapter is further divided to cover specifics related to a particular topic, including normal physiology, pathophysiology, pathogenesis, epidemiology, clinical features, symptoms, diagnosis, differential diagnosis, and therapy. Chapters are written by world renowned clinicians with significant research experience in the particular topic. Although this is rather large and extensive textbook, chapters are easy to read and follow and are clear in content. A valuable addendum to this edition is the CD-ROM although it can be slightly difficult to navigate. The last part provides useful information on laboratory testing in infants and children with reference ranges for laboratory tests and procedures. A useful chapter covers herbal medicine.
Assessment: This 17th edition has undergone substantial revision and reorganization. There are a number of new chapters as well as substantial expansion or significant modification of others. This excellent new edition should be well received. The writing is first class, clear and to the point. I studied for my board exam from the15th edition. I am pleased to see this updated edition that is even more informative and indispensable.
From the Publisher
"This Product provides a wealth of information along with updates which could never be provided in as easy as seamless a way as they are presented here.Most textbooks would do well to emulate this format in years to come." -Doody's Book Review Service

"It is clear that the usefulness of Nelson's 17th edition has been greatly increased by its textual revisions and by the addition of its CD-accessed interactive Web site." —JAMA

5 Stars! from Doody
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Product Details

  • ISBN-13: 9780721603902
  • Publisher: Elsevier Health Sciences
  • Publication date: 5/29/2003
  • Edition description: REV
  • Edition number: 17
  • Pages: 2672
  • Product dimensions: 9.00 (w) x 11.50 (h) x 2.50 (d)

Table of Contents

Part I: The Field of Pediatrics

1. Overview of Pediatrics
2. Ethics in Pediatric Care
3. Cultural Issues in Pediatric Care
4. Child Health in the Developing World
5. Preventative Pediatrics
6. The Well Child

Part II: Growth and Development

7. Overview and Assessment of Variability
8. Fetal Growth and Development
9. The Newborn
10. The First Year
11. The Second Year
12. Preschool Years
13. Middle Childhood
14. Adolescence
15. Assessment of Growth
16. Developmental Assessment

Part III: Psychological Disorders

17. Assessment and Interviewing
18. Psychiatric Considerations of Central Nervous
19. Psychosomatic Illness
20. Vegetative Disorders
21. Habit Disorders
22. Anxiety Disorders
23. Mood Disorders
24. Suicides and Attempted Suicide
25. Disruptive Behavioral Disorders
26. Sexual Behavior and its Variations
27. Pervasive Developmental Disorders and Childhood Psychosis
28. Psychologic Treatment of Children and Adolescents
29. Neurodevelopmental Dysfunction in the School-Aged Child

Part IV: Social Issues

30. Adoption
31. Foster Care
32. Child Care
33. Separations and Death
34. Impact of Violence on Children
35. Abuses and Neglect of Children

Part V: Children with Special Health Needs

36. Failure to Thrive
37. Developmental Disabilities and Chronic Illness: An Overview
38. Pediatric Palliative Care: The Care of Children with Life-Limiting Illness
39. Children at Special Risk

Part VI: Nutrition

40. NutritionalRequirements
41. The Feeding of Infants and Children
42. Food Insecurity, Hunger, and under nutrition
43. Obesity
44. Vitamin Deficiencies and Excesses

Part VII: Pathophysiology of Body Fluids and Fluid Therapy

45. Electrolyte and Acid-Base Disorders
46. Maintenance and Replacement Therapy
47. Deficit Therapy
48. Fluids and Electrolyte Treatment of Specific Disorders

Part VIII: The Acutely Ill Child

49. Evaluation of the Sick Child in the Office and Clinic
50. Injury Control
51. Emergency Medical Services for Children
52. Pediatric Critical Care: An Overview
53. Interfacility Transfer of the Critically Ill Infant and Child
54. Effective Communication With Families in the PICU
55. Monitoring Techniques for the Critically Ill Infant and Child
56. Scoring Systems and Predictors of Mortality
57. Stabilization of the Critically Ill Child
58. Acute (Adult) Respiratory Distress Syndrome; ARDS
59. Continuous Hemofiltration
60. Transplantation Issues in the PICU
61. Drowning and Near Drowning
62. Burn Injuries
63. Cold Injuries
64. Withdrawal or Withholding of Life Support, Brain Death and Organ Procurement
65. Anesthesia and Perioperative Care
66. Pain Management in Children

Part IX: Human Genetics

67. The Molecular Basis of Genetic Disorders
68. Molecular Diagnosis of Genetic Diseases
69. Patterns of Inheritance
70. Chromosomal Clinical Abnormalities
71. Gene Therapy
72. Genetic Counseling

Part X: Metabolic Diseases

73. An Approach to Inborn Errors of Metabolism
74. Defects in Metabolism of Amino Acids
75. Defects in Metabolism of Lipids
76. Defects in Metabolism of Carbohydrates
77. Mucopolysaccharidoses
78. Disorders of Purine and Pyrimidine Metabolism
79. Progeria
80. The Porphyrias
81. Hypoglycemia

Part XI: The Fetus and Neonatal Infant

Section 1. Noninfectious Disorders
82. Overview of Mortality and Morbidity
83. The Newborn Infant
84. High-Risk Pregnancies
85. The Fetus
86. The High-Risk Infant
87. Clinical Manifestations of Diseases in the Newborn Period
88. Nervous System Disorders
89. Delivery Room Emergencies
90. Respiratory Tract Disorders
91. Digestive System Disorders
92. Blood Disorders
93. Genitourinary System
94. The Umbilicus
95. Metabolic Disturbances
96. The Endocrine System
97. Dysmorphology
Section 2. Infections of the Neonatal Infant
98. Pathogenesis and Epidemiology

Part XII: Special Health Problems During Adolescence

99. The Epidemiology of Adolescent Health Problems
100. Delivery of Health Care to Adolescents
101. Depression
102. Suicide
103. Violent Behavior
104. Anorexia Nervosa and Bulimia
105. Substance Abuse
106. The Breast
107. Menstrual Problems
108. Contraception
109. Pregnancy
110. Sexually Transmitted Diseases
111. Chronic Fatigue Syndrome

Part XIII: The Immunologic System and Disorders

Section 1. Evaluation of the Immune Systems
112. Evaluation of Suspected Immunodeficiency
Section 2. The T-, B-, and NK-Cell Systems
113. T Lymphocytes, B Lymphocytes, and Natural Killer Cells
114. Primary Defects of Antibody Production
115. Primary Defects of Cellular Immunity
116. Primary Combined Antibody and Cellular Immunodeficiencies
Section 3. The Phagocytic System
117. Neutrophils
118. Monocytes and Macrophages
119. Eosinophils
120. Disorders of Phagocyte Function
121. Leukopenia
122. Leukocytosis
Section 4. The Complement System
123. The Complement System
124. Disorders of the Complement System
Section 5. Hematopoietic Stem Cell Transplantation
125. Clinical Indications
126. Matching and Rejection
127. Graft vs Host Disease (GVHD)
128. Principles of Immune Suppression
129. Late Effects of Bone Marrow Transplantation

Part XIV: Allergic Disorders

130. Allergy and the Immunologic Basis of Atopic Disease
131. Diagnosis of Allergic Disease
132. Principles of Treatment of Allergic Disease
133. Allergic Rhinitis
134. Childhood Asthma
135. Atopic Dermatitis (Atopic Eczema)
136. Urticaria and Angioedema (Hives)
137. Anaphylaxis
138. Serum Sickness
139. Adverse Reactions to Drugs
140. Insect Allergy
141. Ocular Allergies
142. Adverse Reactions to Foods

Part XV: Rheumatic Diseases of Childhood (Connective Tissue Diseases, Collagen Vascular Disease)

143. Evaluation of Suspected Rheumatic Disease
144. Treatment of Rheumatic Diseases
145. Juvenile Rheumatoid Arthritis
146. Ankylosing Spondylitis and Other Spondyloarthropathies
147. Postinfectious Arthritis and Related Conditions
148. Systemic Lupus Erythematosus
149. Juvenile Dermatomyositis
150. Scleroderma
151. BehVet’s Disease
152. Sjögren’s Syndrome
153. Familial Mediterranean Fever
154. Amyloidosis
155. Sarcoidosis
156. Kawasaki Disease
157. Vasculitis Syndromes
158. Musculoskeletal Pain Syndromes
159. Miscellaneous Conditions Associated With Arthritis

Part XVI: Infectious Diseases

Section 1. General Considerations
160. Diagnostic Microbiology
161. Fever
162. Fever without a Focus
163. Sepsis and Shock
164. Infections in Immunocompromised Hosts
165. Infections Associated with Medical Devices
Section 2. Gram-Positive Bacterial Infections
166. Staphylococcus
167. Streptococcus Pneumonia (Pneumococcus)
168. Group A Strptococcus
169. Group B Streptococcus
170. Non-Group A or B Streptococcus
171. Enterococcus
172. Diphtheria (Corynebacterium Diphtheriae)
173. Listeria monocytogenes
174. Actinomyces
175. Nocardia
Section 3. Gram Negative Bacterial Infections
176. Neisseria meningitidis (Meningococcus)
177. Neisseria gonorrhoeae (Gonococcus)
178. Haemophilus influenzae
179. Chancroid (Haemophilus ducreyi)
180. Pertussis (Bordetella pertussis and B. parapertussis)
181. Salmonella
182. Shigella
183. Escherichia coli
184. Cholera (Vibrio cholerae)
185. Campylobacter
186. Yersinia
187. Aeromonas and Plesiomonas
188. Pseudomonas, Burkholderia, and Stenotrophomonas
189. Tularemia (Francisella tularensis)
190. Brucella
191. Legionella
192. Bartonella
Section 4. Anaerobic Bacterial Infections
193. Botulism (Clostridium botulinum)
194. Tetanus (Clostridium tetani)
195. Clostridium difficile–Associated Diarrhea
196. Other Anaerobic Infections
Section 5. Mycobacterial Infections
197. Tuberculosis (Mycobacterium tuberculosis)
198. Hansen’s Disease (Mycobacterium leprae)
199. Nontuberculous Mycobacteria
Section 6. Spirochetal Infections
200. Syphilis (Treponema pallidum)
201. Nonveneral Treponemal Infections
202. Leptospira
203. Relapsing Fever (Borrelia)
204. Lyme Disease (Borrelia burgdorferi)
Section 7. Mycoplasmal Infections
205. Mycoplasma pneumoniae
206. Genital Mycoplasmas (Mycoplasma hominis and Ureaplasm urealyticum)
Section 8. Chlamydial Infections
207. Chlamydia pneumoniae
208. Chlamydia trachomatis
209. Psittacosis (Chlamydia psittaci)
Section 9. Rickettsial Infections
210. Spotted Fever Group Rickettsioses
211. Scrub Typhus (Orientia tsutsugamushi)
212. Typhus Group Rickettsioses
213. Ehrlichioses
214. Q Fever (Coxiella burnetii)
Section 10. Mycotic Infections
215. Candida
216. Cryptococcus neoformans
217. Malassezia
218. Aspergillus
219. Histoplasmosis (Histoplasma capsulatum)
220. Blastomycosis (Blastomyces dermatitidis)
221. Coccidioidomycosis (Coccidioides immitis)
222. Paracoccidioides brasiliensis
223. Sporotrichosis (Sporothrix schenckii)
224. Zygomycosis
Section 11. Viral Infections
225. Measels
226. Rubella
227. Mumps
228. Polioviruses
229. Nonpolio Enteroviruses
230. Parvovirus B19
231. Herpes Simplex Virus
232. Varicella-Zoster Virus
233. Epstein-Barr Virus
234. Cytomegalovirus
235. Roseola (Human Herpesviruses 6, 7)
236. Human Herpesvirus 8
237. Influenza Viruses
238. Parainfluenza Viruses
239. Respiratory Syncytial Virus
240. Adenoviruses
241. Rhinoviruses
242. Rotavirus and Other Agents of Viral Gastroenteritis
243. Papillomaviruses
244. Arboviral Encephalitis of North America
245. Arboviral Encephalitis Outside North America
246. Dengue Fever and Dengue Hemorrhagic Fever
247. Yellow Fever
248. Other Viral Hemorrhagic Fevers
249. Lymphocytic Choriomeningitis Virus
250. Hantaviruses
251. Rabies
252. Polyomaviruses
253. Transmissible Spongiform Encephalopathies
254. Acquired Immunodeficiency Syndrome (Human Immunodeficiency Virus)
255. Human T-Cell Lymphotropic Viruses Types I and II
Section 12. Protozoan Diseases
256. Primary Amebic Meningoencephalitis
257. Amebiasis
258. Giardiasis and Balantidiasis
259. Spore-Forming Intestinal Protozoa
260. Trichomoniasis (Trichomonas vaginalis)
261. Leishmaniasis (Leishmania)
262. African Trypanosomiasis (Sleeping Sickness; Trypanosoma brucei complex)
263. American Trypanosomiasis (Chagas Disease; Trypanosoma cruzi)
264. Malaria (Plasmodium)
265. Babesiosis (Babesia)
266. Toxoplasmosis (Toxoplasma gondii)
267. Pneumocystis carinii
Section 13. Helminthic Diseases
268. Ascariasis (Ascaris lumbricoides)
269. Hookworms (Ancylostoma and Necator americanus)
270. Trichuriasis (Trichuris trichuria)
271. Enterobiasis (Enterobius vermicularis)
272. Strongyloidiasis (Strongyloides stercoralis)
273. Lymphatic Filariasis (Brugia malayi, B. timori, and Wuchereria bancrofti)
274. Other Tissue Nematodes
275. Toxocariasis (Visceral and Ocular Larva Migrans)
276. Trichinosis (Trichinella spiralis)
277. Schistosomiasis (Schistosoma)
278. Flukes: (Liver, Lung, and Intestinal)
279. Adult Tapeworm Infections
280. Cysticercosis
281. Echinococcosis (Echinococcus granulosus and E. multilocularis)
Section 14. Preventive Measures
282. Immunization Practices
283. Infection Control and Prophylaxis
284. Childcare and Communicable Diseases
285. Health Advice for Children Traveling Internationally

Part XVII. The Digestive System

Section 1. Clinical Manifestations of Gastrointestinal Disease
286. Normal Digestive Tract Phenomena
287. Major Symptoms and Signs of Digestive Tract Disorders
Section 2. The Oral Cavity
288. Development and Developmental Anomalies of the Teeth
289. Disorders of the Oral Cavity Associated with Other Conditions
290. Malocclusion
291. Cleft Lip and Palate
292. Syndromes with Oral Manifestations
293. Dental Caries
294. Periodontal Diseases
295. Dental Trauma
296. Common Lesions of the Oral Soft Tissues
297. Diseases of the Salivary Glands and Jaws
298. Diagnostic Radiology in Dental Assessment
Section 3. The Esophagus
299. Embryology, Anatomy, and Function of the Esophagus
300. Congenital Anomalies: Esophageal Atresia and Tracheoesophageal Fistula
301. Obstructing and Motility Disorders of the Esophagus
302. Dysmotility
303. Hiatal Hernia
304. Gastroesophageal Reflux Disease (GERD)
305. Non-GERD Esophagitis
306. Esophageal Perforation
307. Esophageal Varices
308. Ingestions
Section 4. Stomach and Intestines
309. Normal Development, Structure, and Function
310. Pyloric Stenosis and Other Congenital Anomalies of the Stomach
311. Intestinal Atresia, Stenosis, and Malrotation
312. Intestinal Duplications, Meckel Diverticulum and Other Remnants of the Omphalomesenteric Duct
313. Motility Disorders and Hirschsprung Disease
314. Ileus, Adhesions, Intussusception, and Closed-Loop Obstructions
315. Foreign Bodies and Bezoars
316. Peptic Ulcer Disease on Children
317. Inflammatory Bowel Disease
318. Food Allergy (Food Hypersensitivity)
319. Eosinophilic Gastroenteritis
320. Malabsorptive Disorders
321. Gastroenteritis
322. Chronic Diarrhea
323. Recurrent Abdominal Pain of Childhood
324. Acute Appendicitis
325. Surgical Conditions of the Anus, Rectum, and Colon
326. Tumors of the Digestive Tract
327. Inguinal Hernias
Section 5. Exocrine Pancreas
328. Embryology, Anatomy, and Physiology
329. Pancreatic Function Tests
330. Disorders of the Exocrine Pancreas
331. Treatment of Pancreatic Insufficiency
332. Pancreatitis
333. Pseudocyst of the Pancreas
334. Pancreatic Tumors
Section 6. The Liver and Biliary System
335. Morphogenesis of the Liver and Biliary System
336. Manifestations of Liver Disease
337. Cholestasis
338. Metabolic Diseases of the Liver
339. Viral Hepatitis
340. Liver Abscess
341. Liver Disease Associated with Systemic Disorders
342. Reye Syndrome and the Mitochondrial Hepatopathies
343. Autoimmune (Chronic) Hepatitis
344. Drug- and Toxin-Induced Liver Injury
345. Fulminant Hepatic Failure
346. Cystic Diseases of the Biliary Tract and Liver
347. Diseases of the Gallbladder
348. Portal Hypertension and Varices
349. Liver Transplantation
Section 7. Peritoneum
350. Malformations
351. Ascites
352. Peritonitis
353. Diaphragmatic Hernia
354. Epigastric Hernia

Part XVIII: Respiratory System

Section 1. Development and Function
355. Development of the Respiratory System
356. Regulation of Respiration
357. Respiratory Pathophysiology
358. Defense Mechanisms and Metabolic Functions of the Lung
359. Diagnostic Approach to Respiratory Disease
360. Sudden Infant Death Syndrome
Section 2. Upper Respiratory Tract
361. Congenital Disorders of the Nose
362. Acquired Disorders of the Nose
363. Nasal Polyps
364. The Common Cold
365. Sinusitis
366. Pharyngitis
367. Retropharyngeal Abscess, Lateral Pharyngeal (Parapharyngeal) Abscess, and Peritonsillar Cellulitis/Abscess)
368. Tonsils and Adenoids
369. Obstructive Sleep Apnea and Hypoventilation in Children
Section 3. Disorders of the Lungs and Lower Airway
370. Chronic or Recurrent Respiratory Symptoms
371. Acute inflammatory Upper Airway Obstruction
372. Congenital Anomalies of the Larynx
373. Foreign Bodies of the Airway
374. Neoplasms of the Larynx, Trachea, and Bronchi
375. Inflammatory Disorders of the Small Airways
376. Wheezing in Infants
377. Emphysema and Overinflation
378. α1-Antitrypsin Deficiency and Emphysema
379. Other Distal Airway Disease
380. Congenital Disorders of the Lung
381. Pulmonary Edema
382. Aspiration Syndromes
383. Chronic Recurrent Aspiration
384. Gastroesophageal Reflux and Respiratory Disorders
385. Parenchymal Disease with Prominent Hypersensitivity, Eosonophilic Infiltration, or Toxin-Mediated Injury
386. Pneumonia
387. Slowly Resolving Pneumonia
388. Bronchiectasis
389. Pulmonary Abscess
390. Cystic Fibrosis
391. Primary Ciliary Dyskinesia (Immotile Cilia Syndrome)
392. Interstitial Lung Disease
393. Pulmonary Alveolar Proteinosis
394. Inherited Disorders of Surfactant Protein Metabolism
395. Pulmonary Hemosiderosis
396. Pulmonary Hemorrhage, Embolism, and Infarction
397. Atelectasis
398. Pulmonary Tumors
399. Pleurisy
400. Pneumothorax
401. Pneumomediastinum
402. Hydrothorax
403. Hemothorax
404. Chylothorax
405. Bronchopulmonary Dysplasia
406. Skeletal Diseases Influencing Pulmonary Consequences
407. Neuromuscular Diseases with Pulmonary Consequences
408. Extrapulmonary Diseases with Pulmonary Manifestations
409. Chronic Severe Respiratory Insufficiency

Part XIX: The Cardiovascular System

Section 1. Developmental Biology of the Cardiovascular System
413. Cardiac Development
414. The Fetal to Neonatal Circulatory Transition
Section 2. Evaluation of the Cardiovascular System
415. History and Physical Examination
416. Laboratory Evaluation
Section 3. Congenital Heart Disease
417. Epidemiology of Congenital
Heart Disease
418. Evaluation of the Infant or Child
419. Acyanotic Congeital Heart Disease: The Left Ventricular Septal Defect to-Right Shunt Lesions
420. Acyanotic Congenital Heart Disease: The Obstructive Lesions
421. Acyanotic Congenital Heart Disease: Regurgitant Lesions
422. Cyanotic Congenital Heart Disease: Evaluation of the Critically Ill Neonate with Cyanosis and Respiratory Distress
423. Cyanotic Congenital Heart Lesions: Lesions Associated with Decreased Pulmonary Blood Flow
424. Cyanotic Congenital Heart Disease: Lesions Associated with Increased Pulmonary Blood Flow
425. Other Congenital Heart and Vascular Malformations
427. General Principles of Treatment of Congenital Heart Disease
Section 4. Cardiac Arrhythmias
428. Disturbances of Rate and Rhythm of the Heart
Section 5. Acquired Heart Disease
429. Infective Endocarditis
430. Rheumatic Heart Disease
Section 6. Diseases of the Myocardium and Pericardium
431. Diseases of the Myocardium
432. Diseases of the Pericardium
433. Tumors of the Heart
Section 7. Cardiac Therapeutics
434. Heart Failure
435. Pediatric Heart and Heart-Lung Transplantation
Section 8. Diseases of the Peripheral Vascular System
436. Diseases of the Blood Vessels (Aneurysms and Fistulas)
437. Systemic Hypertension

Part XX: Diseases of the Blood

Section 1. The Hematopoietic System
438. Development of the Hematopoietic System
439. The Anemias
Section 2. Anemias of Inadequate Production
440. Congenital Hypoplastic Anemia (Diamond-Blackfan Anemia
441. Pearson Marrow-Pancreas Syndrome
442. Acquired Pure Red Blood Cell Anemias
443. Anemia of Chronic Disorders (ACD) and Renal Disease
444. Congenital Dyserythropoietic Anemias (CDA)
445. Physiologic Anemia of Infancy
446. Megaloblastic Anemias
447. Iron Deficiency Anemia
448. Other Microcytic Anemias
Section 3. Hemolytic Anemias
449. Definitions and Classification of Hemolytic Anemias
450. Hereditary Spherocytosis
451. Hereditary Elliptocytosis
452. Hereditary Stomatocytosis
453. Other Membrane Defects
454. Hemoglobin Disorders
455. Enzymatic Defects
456. Hemolytic Anemias Resulting from Extracellular Factors
457. Hemolytic Anemias Secondary to Other Extracellular Factors
Section 4. Polycythemia (Erythrocytosis)
458. Primary Polycythemia (Polycythemia Rubra Vara)
459. Secondary Polycythemia
Section 5. The Pancytopenias
460. The Constitutional Pancytopenias
461. The Acquired Pancytopenias
Section 6. Risks of Blood Component Transfusions
462. Red Blood Cell Transfusions and Erythropoietin Therapy
463. Platelet Transfusions
464. Neutrophil (Granulocyte) Transfusions
465. Fresh Frozen Plasma Transfusions
466. Risks of Blood Transfusions
Section 7. Hemorrhage and Thrombotic Diseases
467. Hemostasis
468. Hereditary Clotting Factor Deficiencies (Bleeding Disorders)
469. von Willebrand Disease
470. Hereditary Predisposition to Thrombosis
471. Acquired Thrombotic Disorders
472. Postneonatal Vitamin K Deficiency
473. Liver Disease
474. Acquired Inhibitors of Coagulation
475. Disseminated Intravascular Coagulation (Consumptive Coagulopathy
476. Platelet and Blood Vessel Disorders
Section 8. The Spleen
477. Anatomy and Function of the Spleen
478. Splenomegaly
479. Hyposplenism, Splenic Trauma, and Splenectomy
Section 9. The Lymphatic System
480. Anatomy and Function of the Lymphatic System
481. Abnormalities of Lymphatic vessels
482. Lymphadenopathy

Part XXI: Cancer and Benign Tumors

483. Epidemiology of Childhood and Adolescent Cancer
484. Molecular and Cellular Biology of Cancer
485. Principles of Diagnosis
486. Principles of Treatment
487. The Leukemias
488. Lymphoma
489. Brain Tumors in Children
490. Neuroblastoma
491. Neoplasms of the Kidney
492. Soft Tissue Sarcomas
493. Neoplasms of Bone
494. Retinoblastoma
495. Gonadal and Germ Cell Neoplasms
496. Neoplasms of the Liver
497. Benign Vascular Tumors
498. Rare Tumors
499. Histiocytosis Syndromes of Childhood

Part XXII: Nephrology

Section 1. Glomerular Disease
500. Introduction to Glomerular Diseases
Section 2. Conditions Particularly Associated with Hematuria
501. Clinical Evaluation of the Child with Hematuria
502. Isolated Glomerular Disease with Recurrent Gross Hematuria
503. Glomerulonephritis Associated with Infections
504. Membranous Glomerulopathy
505. Membranoproliferative (Mesangiocapillary) Glomerulonephritis
506. Glomerulonephritis Associated With Systemic Lupus Erythematosus
507. Henoch-Schonlein Purpura Nephritis
508. Rapidly Progressive (Crescentic)
509. Goodpasture Disease
510. Hemolytic-Uremic Syndrome
511. Upper Urinary Tract Causes of Hem
512. Hematologic Diseases Causing Hemturia
513. Anatomic Abnormalities Associated with hematuria
514. Lower Urinary Tract Causes
Section 3. Conditions Particularly Associated with Proteinuria
515. Introduction to the Child with Proteinuria
516. Transient Proteinura
517. Orthostatic (Postural) Proteinuria
518. Fixed Proteinuria
519. Nephrotic Syndrome
Section 4. Tubular Disorders
520. Tubular Function
521. Renal Tubular Acidosis
522. Nephrogenic Diabetes Insipidus
523. Bartter/Gitelman Syndromes and Other Inherited Tubular Transport
524. Tubulointerstitial Nephritis
Section 5. Toxic Nephropathies-Renal Failure
525. Toxic Nephropathy
526. Cortical Necrosis
527. Renal Failure
528. Renal Transplantation

Part XXIII: Urologic Disorders in Infants and Children

529. Congenital Anomalies and Dysgenesis of the Kidneys
530. Urinary Tract Infections
531. Vesicoureteral Reflux
532. Obstructions of the Urinary Tract
533. Anomalies of the Bladder
534. Neuropathic Bladder
535. Voiding Dysfunction
536. Anomalies of the Penis and Urethra
537. Disorders and Anomalies of the Scrotal Contents
538. Trauma to the Genitourinary Tract
539. Urinary Lithiasis

Part XXIV: Gynecologic Problems of Childhood

540. History and Physical Examination
541. Vulvovaginitis
542. Bleeding
543. Breast Disorders
544. Hirsutism and Polycystic Ovarian Syndrome
545. Neoplasms
546. Vulvovaginal and Mullerian Anomalies
547. Athletic Gynecologic Problems
548. Special Gynecologic Needs
549. Gynecologic Imaging

Part XXV: The Endocrine System

Section 1: Disorders of the Hypothalamus and Pituitary Gland
550. Hormones of the Hypothalamus and Pituitary
551. Hypotituitarism
552. Diabetes Inspidus
553. Other Abnormalities of Arginine Vasopressin Metabolism and Action
554. Hyperpituitarism, Tall Stature, and Overgrowth Syndromes
555. Physiology of Puberty
556. Disorders of Pubertal Development
Section 2: Disorders of the Thyroid Gland
557. Thyroid Development and Physiology
558. Defects of Thyroxine-Binding Globulin
559. Hypthyroidism
560. Throiditis
561. Goiter
562. Hyperthyroidism
563. Carcinoma of the Thyroid
Section 3: Disorders of the Parathyroid Glands
564. Hormones and Peptides of Calcium Hemeostasis and Bone Metabolism
565. Hypoparathyroidism
566. Pseudohypoparathyroidism (Albright Hereditary Osteodystrophy)
567. Hyperparathyroidism
Section 4: Disorders of the Adrenal Glands
568. The Physiology of the Adrenal Gland
569. Adrenocortical Insufficiency
570. Congenital Adrenal Hyperplasia and Related Disorders
571. Cushing’s Syndrome
572. Primary Aldosteronism
573. Adrenal Tumors
574. Pheochromocytoma
575. Adrenal Masses
Section 5. Disorders of the Gonads
576. Development and Function of the Gonads
577. Hypofunction of the Testes
578. Pseudoprecocity Resulting from Tumors of The Testes
579. Gynecomastia
580. Hypofunction of the Ovaries
581. Pseudoprecocity Due to Lesions of the Ovary
582. Intersex
Section 6. Diabetes Mellitus In Children
583. Diabetes Mellitus

Part XXVI: The Nervous System

584. Neurologic Evaluation
585. Congenital Anomalies of the Central Nervous System
586. Seizures in Childhood
587. Conditions that Mimic Seizures
588. Headaches
589. Neurocutaneous Syndromes
590. Movement Disorders
591. Encephalopathies
592. Neurodegenerative Disorders of Childhood
593. Acute Stroke Syndromes
594. Central Nervous System Infections
595. Brain Abscess
596. Pseudotumor Cerebri
597. Spinal Cord Disorders

Part XXVII: Neuromuscular Disorders

598. Evaluation and Investigation
599. Developmental Disorders of Muscle
600. Muscular Dystrophies
601. Endocrine Myopathies
602. Metabolic Myopathies Myopathy
603. Disorders of Neuromuscular Transmission and of Motor Neurons
604. Hereditary Motor-Sensory Neuropathies
605. Toxic Neuropathies
606. Autonomic Neuropathies
607. Guillain-Barré Syndrome
608. Bell Palsy

Part XXVIII: Disorders of the Eye

609. Growth and Development
610. Examination of the Eye
611. Abnormalities of Refraction and Accommodation
612. Disorders of Vision
613. Abnormalities of Pupil and Iris
614. Disorders of Eye Movement and Alignment
615. Abnormalities of the Lids
616. Disorders of the Lacrimal System
617. Disorders of the Conjunctiva
618. Abnormalities of the Cornea
619. Abnormalities of the Lens
620. Disorders of the Uveal Tract
621. Disorders of the Retina and Vitreous
622. Abnormalities of the Optic Nerve
623. Childhood Glaucoma
624. Orbital Abnormalities
625. Injuries to the Eye

Part XXIX: The Ear

626. Clinical Manifestations
627. Hearing Loss
628. Congenital Malformations
629. Diseases of the External Ear
630. Otitis Media
631. The Inner Ear and Diseases of the Bony Labyrinth
632. Traumatic Injuries of the Ear and Temporal Bone
633. Tumors of the Ear and Temporal Bone

Part XXX: The Skin

634. Morphology of the Skin
635. Evaluation of the Patient
636. Principles of Therapy
637. Diseases of the Neonate
638. Cutaneous Defects
639. Ectodermal Dysplasias
640. Vascular Disorders
641. Cutaneous Nevi
642. Hyperpigmented Lesions
643. Hypopigmented Lesions
644. Vesiculobullous Disorders
645. Eczematous Disorders
646. Photosensitivity
647. Diseases of the Epidermis
648. Disorders of Keratinization
649. Diseases of the Dermis
650. Diseases of Subcutaneous Tissue
651. Disorders of the Sweat Glands
652. Disorders of Hair
653. Disorders of the Nails
654. Disorders of the Mucous Membranes
655. Cutaneous Bacterial Infections
656. Cutaneous Fungal Infections
657. Cutaneous Viral Infections
658. Arthropod Bites and Infestations
659. Acne
660. Tumors of the Skin
661. Nutritional Dermatoses

Part XXXI: Bone and Joint Disorders

Section 1. Orthopaedic Problems
662. Growth and Development
663. Evaluation of the Child
664. The Foot and Toes
665. Torsional and Angular Deformities
666. Leg Length Discrepancy
667. The Knee
668. The Hip
669. The Spine
670. The Neck
671. The Upper Limb and Finger
672. Arthrogryposis
673. Common Fractures
674. Osteomyelitis and Suppurative Arthritis
Section 2. Sports Medicine
675. Epidemiology and Prevention
676. Management of Musculoskeletal Injury
677. Head and Neck Injuries
678. Heat Injuries
679. Female Athletes: Menstrual Problems and Risk for Osteopenia
680. Ergogenic Aids
681. Specific Sports and Associated Injuries
Section 3. The Skeletal Dysplasias
682. General Considerations
683. Disorders of Involving Cartilage Matrix Proteins
684. Disorders Involving Transmembrane Receptors
685. Disorders Involving Ion Transporter
686. Disorders Involving Transcription Factors
687. Disorders Involving Defective Bone Resorption
688. Disorders for Which Defects Are Poorly Understood or Unknown
689. Osteogenesis Imperfecta (OI)
690. Marfan Syndrome
Section 4. Metabolic Bone Disease
691. Bone Structure, Growth, and Hormonal Regulation
692. Primary Chondrodystrophy (Metaphyseal Dysplasia)
693. Idiopathic Hypercalcemia
694. Hypophosphatasia
695. Hyperphosphatasia
696. Familial Hypophosphatemia (Vitamin D--Resistant Rickets, X-Linked Hypophosphatemia)
697. Vitamin D-Dependent Rickets (Pseudovitamin D Deficiency, Hypocalcemic Vitamin D--Resistant Rickets)
698. Oncogenous Rickets (Primary Hypophosphatemic Rickets Associated with Tumor)
699. Osteoporosis

Part XXXII: Environmental Health Hazards

700. Pediatric Radiation Injuries
701. Chemical Pollutants
702. Heavy Metal Intoxication
703. Lead Poisoning
704. Poisonings: Drugs, Chemicals, and Plants
705. Nonbacterial Food Poisoning
706. Biologic and Chemical Terrorism
707. Animal and Human Bites
708. Envenomations

Part XXXIII: Laboratory Medicine, Drug Therapy, and Reference Tables

709. Laboratory Testing in Infants and Children
710. Reference Ranges for Laboratory Tests and Procedures
711. Principles of Drug Therapy
712. Medications
713. Herbal Medicines
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