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Doody ReviewsReviewer: Anamarija M Perry, MD (University of Cincinnati College of Medicine)
Description: This overview of the discipline of hematopathology connects the field with the recent advances in immunology research and with current clinical practice in the treatment of lymphomas and leukemias.
Purpose: The intent is to provide readers with an understanding of hematologic neoplasms from a multidisciplinary perspective. This field indeed encompasses many disparate disciplines, including laboratory medicine, molecular diagnostics, surgical pathology, clinical hematology, and translational science, which the authors, impressively, have been able to tie together to achieve their stated goals.
Audience: It is intended as a reference for practicing hematopathologists and surgical pathologists. Pathology residents and hematopathology fellows also will find it useful as a tool for board preparation. It offers an excellent overview of diagnostic hematopathology for hematologists-oncologists. In addition, some chapters would be particularly beneficial for experimental scientists and graduate students engaged in research associated with lymphomas and leukemias.
Features: The introductory section deals with classification of leukemias and lymphomas, immunohistochemical profiling, flow cytometry, molecular diagnostics, and cytogenetic testing of hematologic malignancies. The second section is dedicated to bone marrow neoplasms, while the third section deals with tumors of the lymph nodes and extranodal tissues. Section four describes the clinical, molecular, and immunologic aspects of stem cell transplantation. The final section is dedicated to experimental hematopathology, covering such aspects as the role of host genetics in lymphoma, proteomics, mouse models in myeloid leukemia, and targeted therapies in lymphomas and leukemias. A brief study guide at the end of the book includes a list of questions that are addressed in each chapter. The book is fairly well illustrated and the quality of most microphotographs is very good to excellent. There are also numerous useful tables and diagrams.
Assessment: Written by multiple authors, this book is an excellent quick reference for practicing hematopathologists and clinicians. It provides a great overview of normal lymph node and bone marrow histology, and thoroughly explains the principles of the most commonly used ancillary techniques such as flow cytometry and molecular diagnostics. Since it doesn't offer a very systematic and detailed histologic description of diseases, I would not recommend it to those beginning their studies of hematopathology. It does, however, cover in great detail pertinent ancillary studies for each disease which are considered the standard of care in diagnosing and treating leukemias and lymphomas. For those interested in the area, the molecular features of certain entities are very well described. Several chapters are dedicated to staging and therapy of bone marrow and lymph node neoplasms. Multiple routine and experimental therapies are detailed, offering a good overview of possible therapies for each disease. An entire section is dedicated to stem cell transplantation, which is also written primarily for clinicians. Interested hematopathologists can certainly learn a lot from these chapters. Section five, which covers experimental hematopathology, would likely appeal to basic science researchers in the field. The chapters in this section incorporate the most recent and pertinent literature. Many hot topics, such as developing prognostic models for diffuse large B-cell lymphoma and targeted therapies for lymphomas and leukemias, are included. Although the book is fairly well illustrated, there is an insufficient number of representative microphotographs that demonstrate the morphological features of certain diseases. The brief chapter on benign lymph node pathology is poorly organized with a very limited number of described entities. However, this book contains many useful features, including tables and excellent representative flow cytometry histograms. Overall, the authors have done a great job of tying together clinical and pathological aspects of bone marrow and lymph node disorders, emphasizing the importance of the multidisciplinary approach to treating these patients. The book should be widely distributed to departmental libraries, and should become a part of the personal library of all hematopathologists and clinical hematologists. "