Neoplastic Hematopathology: Experimental and Clinical Approaches / Edition 1

Hardcover (Print)
Buy New
Buy New from BN.com
$291.52
Used and New from Other Sellers
Used and New from Other Sellers
from $103.75
Usually ships in 1-2 business days
(Save 68%)
Other sellers (Hardcover)
  • All (4) from $103.75   
  • New (3) from $192.33   
  • Used (1) from $103.75   

Overview

Fulfilling the void with a Hematopathology book that integrates clinical and experimental studies with diagnostic criteria, Neoplastic Hematopathology: Experimental and Clinical Approaches provides an overview of the discipline of hematopathology that connects the field with recent advances in immunology research and current clinical practice in the treatment of lymphomas and leukemias. Designed for both trainees and specialists in pathology and hematology-oncology, Neoplastic Hematopathology: Experimental and Clinical Approaches has separate sections on laboratory techniques, diagnostic hematopathology, treatment and stem cell transplantation. Expert chapter authors address both myeloid and lymphoid tumors, and provide much needed coverage in transplant biology. A study guide highlights key chapter points, making the text suitable for boards review in hematopathology and hematology-oncology.

Read More Show Less

Editorial Reviews

Doody Reviews
Reviewer: Anamarija M Perry, MD (University of Cincinnati College of Medicine)
Description: This overview of the discipline of hematopathology connects the field with the recent advances in immunology research and with current clinical practice in the treatment of lymphomas and leukemias.
Purpose: The intent is to provide readers with an understanding of hematologic neoplasms from a multidisciplinary perspective. This field indeed encompasses many disparate disciplines, including laboratory medicine, molecular diagnostics, surgical pathology, clinical hematology, and translational science, which the authors, impressively, have been able to tie together to achieve their stated goals.
Audience: It is intended as a reference for practicing hematopathologists and surgical pathologists. Pathology residents and hematopathology fellows also will find it useful as a tool for board preparation. It offers an excellent overview of diagnostic hematopathology for hematologists-oncologists. In addition, some chapters would be particularly beneficial for experimental scientists and graduate students engaged in research associated with lymphomas and leukemias.
Features: The introductory section deals with classification of leukemias and lymphomas, immunohistochemical profiling, flow cytometry, molecular diagnostics, and cytogenetic testing of hematologic malignancies. The second section is dedicated to bone marrow neoplasms, while the third section deals with tumors of the lymph nodes and extranodal tissues. Section four describes the clinical, molecular, and immunologic aspects of stem cell transplantation. The final section is dedicated to experimental hematopathology, covering such aspects as the role of host genetics in lymphoma, proteomics, mouse models in myeloid leukemia, and targeted therapies in lymphomas and leukemias. A brief study guide at the end of the book includes a list of questions that are addressed in each chapter. The book is fairly well illustrated and the quality of most microphotographs is very good to excellent. There are also numerous useful tables and diagrams.
Assessment: Written by multiple authors, this book is an excellent quick reference for practicing hematopathologists and clinicians. It provides a great overview of normal lymph node and bone marrow histology, and thoroughly explains the principles of the most commonly used ancillary techniques such as flow cytometry and molecular diagnostics. Since it doesn't offer a very systematic and detailed histologic description of diseases, I would not recommend it to those beginning their studies of hematopathology. It does, however, cover in great detail pertinent ancillary studies for each disease which are considered the standard of care in diagnosing and treating leukemias and lymphomas. For those interested in the area, the molecular features of certain entities are very well described. Several chapters are dedicated to staging and therapy of bone marrow and lymph node neoplasms. Multiple routine and experimental therapies are detailed, offering a good overview of possible therapies for each disease. An entire section is dedicated to stem cell transplantation, which is also written primarily for clinicians. Interested hematopathologists can certainly learn a lot from these chapters. Section five, which covers experimental hematopathology, would likely appeal to basic science researchers in the field. The chapters in this section incorporate the most recent and pertinent literature. Many hot topics, such as developing prognostic models for diffuse large B-cell lymphoma and targeted therapies for lymphomas and leukemias, are included. Although the book is fairly well illustrated, there is an insufficient number of representative microphotographs that demonstrate the morphological features of certain diseases. The brief chapter on benign lymph node pathology is poorly organized with a very limited number of described entities. However, this book contains many useful features, including tables and excellent representative flow cytometry histograms. Overall, the authors have done a great job of tying together clinical and pathological aspects of bone marrow and lymph node disorders, emphasizing the importance of the multidisciplinary approach to treating these patients. The book should be widely distributed to departmental libraries, and should become a part of the personal library of all hematopathologists and clinical hematologists. "
Doody's Review Service
Reviewer: Anamarija M Perry, MD (University of Nebraska Medical Center)
Description: This overview of the discipline of hematopathology connects the field with the recent advances in immunology research and with current clinical practice in the treatment of lymphomas and leukemias.
Purpose: The intent is to provide readers with an understanding of hematologic neoplasms from a multidisciplinary perspective. This field indeed encompasses many disparate disciplines, including laboratory medicine, molecular diagnostics, surgical pathology, clinical hematology, and translational science, which the authors, impressively, have been able to tie together to achieve their stated goals.
Audience: It is intended as a reference for practicing hematopathologists and surgical pathologists. Pathology residents and hematopathology fellows also will find it useful as a tool for board preparation. It offers an excellent overview of diagnostic hematopathology for hematologists-oncologists. In addition, some chapters would be particularly beneficial for experimental scientists and graduate students engaged in research associated with lymphomas and leukemias.
Features: The introductory section deals with classification of leukemias and lymphomas, immunohistochemical profiling, flow cytometry, molecular diagnostics, and cytogenetic testing of hematologic malignancies. The second section is dedicated to bone marrow neoplasms, while the third section deals with tumors of the lymph nodes and extranodal tissues. Section four describes the clinical, molecular, and immunologic aspects of stem cell transplantation. The final section is dedicated to experimental hematopathology, covering such aspects as the role of host genetics in lymphoma, proteomics, mouse models in myeloid leukemia, and targeted therapies in lymphomas and leukemias. A brief study guide at the end of the book includes a list of questions that are addressed in each chapter. The book is fairly well illustrated and the quality of most microphotographs is very good to excellent. There are also numerous useful tables and diagrams.
Assessment: Written by multiple authors, this book is an excellent quick reference for practicing hematopathologists and clinicians. It provides a great overview of normal lymph node and bone marrow histology, and thoroughly explains the principles of the most commonly used ancillary techniques such as flow cytometry and molecular diagnostics. Since it doesn't offer a very systematic and detailed histologic description of diseases, I would not recommend it to those beginning their studies of hematopathology. It does, however, cover in great detail pertinent ancillary studies for each disease which are considered the standard of care in diagnosing and treating leukemias and lymphomas. For those interested in the area, the molecular features of certain entities are very well described. Several chapters are dedicated to staging and therapy of bone marrow and lymph node neoplasms. Multiple routine and experimental therapies are detailed, offering a good overview of possible therapies for each disease. An entire section is dedicated to stem cell transplantation, which is also written primarily for clinicians. Interested hematopathologists can certainly learn a lot from these chapters. Section five, which covers experimental hematopathology, would likely appeal to basic science researchers in the field. The chapters in this section incorporate the most recent and pertinent literature. Many hot topics, such as developing prognostic models for diffuse large B-cell lymphoma and targeted therapies for lymphomas and leukemias, are included. Although the book is fairly well illustrated, there is an insufficient number of representative microphotographs that demonstrate the morphological features of certain diseases. The brief chapter on benign lymph node pathology is poorly organized with a very limited number of described entities. However, this book contains many useful features, including tables and excellent representative flow cytometry histograms. Overall, the authors have done a great job of tying together clinical and pathological aspects of bone marrow and lymph node disorders, emphasizing the importance of the multidisciplinary approach to treating these patients. The book should be widely distributed to departmental libraries, and should become a part of the personal library of all hematopathologists and clinical hematologists.
From The Critics
Reviewer: Anamarija M Perry, MD(University of Cincinnati College of Medicine)
Description: This overview of the discipline of hematopathology connects the field with the recent advances in immunology research and with current clinical practice in the treatment of lymphomas and leukemias.
Purpose: The intent is to provide readers with an understanding of hematologic neoplasms from a multidisciplinary perspective. This field indeed encompasses many disparate disciplines, including laboratory medicine, molecular diagnostics, surgical pathology, clinical hematology, and translational science, which the authors, impressively, have been able to tie together to achieve their stated goals.
Audience: It is intended as a reference for practicing hematopathologists and surgical pathologists. Pathology residents and hematopathology fellows also will find it useful as a tool for board preparation. It offers an excellent overview of diagnostic hematopathology for hematologists-oncologists. In addition, some chapters would be particularly beneficial for experimental scientists and graduate students engaged in research associated with lymphomas and leukemias.
Features: The introductory section deals with classification of leukemias and lymphomas, immunohistochemical profiling, flow cytometry, molecular diagnostics, and cytogenetic testing of hematologic malignancies. The second section is dedicated to bone marrow neoplasms, while the third section deals with tumors of the lymph nodes and extranodal tissues. Section four describes the clinical, molecular, and immunologic aspects of stem cell transplantation. The final section is dedicated to experimental hematopathology, covering such aspects as the role of host genetics in lymphoma, proteomics, mouse models in myeloid leukemia, and targeted therapies in lymphomas and leukemias. A brief study guide at the end of the book includes a list of questions that are addressed in each chapter. The book is fairly well illustrated and the quality of most microphotographs is very good to excellent. There are also numerous useful tables and diagrams.
Assessment: "Written by multiple authors, this book is an excellent quick reference for practicing hematopathologists and clinicians. It provides a great overview of normal lymph node and bone marrow histology, and thoroughly explains the principles of the most commonly used ancillary techniques such as flow cytometry and molecular diagnostics. Since it doesn't offer a very systematic and detailed histologic description of diseases, I would not recommend it to those beginning their studies of hematopathology. It does, however, cover in great detail pertinent ancillary studies for each disease which are considered the standard of care in diagnosing and treating leukemias and lymphomas. For those interested in the area, the molecular features of certain entities are very well described. Several chapters are dedicated to staging and therapy of bone marrow and lymph node neoplasms. Multiple routine and experimental therapies are detailed, offering a good overview of possible therapies for each disease. An entire section is dedicated to stem cell transplantation, which is also written primarily for clinicians. Interested hematopathologists can certainly learn a lot from these chapters. Section five, which covers experimental hematopathology, would likely appeal to basic science researchers in the field. The chapters in this section incorporate the most recent and pertinent literature. Many hot topics, such as developing prognostic models for diffuse large B-cell lymphoma and targeted therapies for lymphomas and leukemias, are included. Although the book is fairly well illustrated, there is an insufficient number of representative microphotographs that demonstrate the morphological features of certain diseases. The brief chapter on benign lymph node pathology is poorly organized with a very limited number of described entities. However, this book contains many useful features, including tables and excellent representative flow cytometry histograms. Overall, the authors have done a great job of tying together clinical and pathological aspects of bone marrow and lymph node disorders, emphasizing the importance of the multidisciplinary approach to treating these patients. The book should be widely distributed to departmental libraries, and should become a part of the personal library of all hematopathologists and clinical hematologists. "
Read More Show Less

Product Details

  • ISBN-13: 9781607613831
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 1/29/2010
  • Series: Contemporary Hematology Series
  • Edition description: 2010
  • Edition number: 1
  • Pages: 644
  • Product dimensions: 8.30 (w) x 10.90 (h) x 1.30 (d)

Table of Contents

Section I. Introduction to diagnosis and laboratory techniques

1. Approaches to Classification of Lymphoma and Leukemia
Dan Jones, MD, PhD
2. Immunohishemical Profiling of Lymphoma
Matthew Anderson, MD, PhD, Yasodha Natkunam, MD, PhD
3. Flow Cytometry in the Evaluation of Hematologic Malignancies
Jeffrey L Jorgensen, MD, PhD
4. Molecular Diagnostics and Cytogenetic Testing
Su Chen, MD, PhD, Zhuang Zuo, MD, PhD, Dan Jones, MD

Section II. Neoplasms of the Bone Marrow

5. The Bone Marrow in Normal and Diseased States
Dan Jones, MD, PhD, Roberto N Miranda, MD
6. Myelodysplastic Syndromes and Myelodysplastic/Myeloproliferative Neoplasms
Sa A Wang, MD
7. Acute Myeloid Leukemia
Carlos E Bueso-Ramos, MD, PhD
8. Treatment of Acute Myeloid Leukemia and Myelodysplastic Syndromes
Farhad Ravandi, MD
9. Myeloproliferative Neoplasms
C. Cameron Yin, MD, PhD, Dan Jones, MD, PhD
10. Chronic Myelogenous Leukemia
Robert P Hasserjian, MD
11. Treatment of Myeloproliferative Neoplasms
Starla Sweany, PharmD, BCOP, Elias Jabbour, MD

Section III. Tumors of the Lymph Node and Extranodal Tissues

12. Lymph Node Biology and Lymphadenitis
Roberto N Miranda, MD
13. Lymphoblastic Leukemia and Lymphoma
Andrea M Sheehan, MD
14. Chronic Lymphocytic Leukemia and Small Lymphocytic Lymphoma
Ellen Schlette, MD
15. Marginal Zone Lymphomas
Rachel L Sargent, MD
16. Follicular Lymphoma and Mantle Cell Lymphoma
Dan Jones, MD
17. Aggressive B-Cell Lymphomas: Large B-Cell Lymphoma and Burkitt Lymphoma
Henry Y Dong, MD, PhD
18. Therapy of B-Cell Lymphoproliferative Disorders
Nathan Fowler, MD, Sandra Horowitz, PharmD, Peter McLaughlin, MD
19. Plasma Cell Myeloma and Other Plasma Cell Dyscrasias
Marwan A Yared, MD
20. Hodgkin Lymphoma
Robert Lin, MD, Dan Jones, MD, PhD, Sherif Ibrahim, MD, PhD
21. Treatment of Hodgkin Lymphoma
Luis E Fayad, MD, Samer A Srour, MB, ChB

22. Classification of T-Cell and NK-Cell Malignances
Dan Jones, MD, PhD
23. Treatment of Non-Cutaneous T-Cell and NK-Cell Malignancies
Marco Herling, MD
24. Cutaneous T-Cell Lymphoma
Pranil Chandra, DO, Mauricio P Oyarzo, MD, Dan Jones, MD, PhD
25. Treatment of Cutaneous T-Cell Lymphomas
Katherine M Cox, MD, Madeleine Duvic, MD
26. Histiocytic and Dendritic Cell Neoplasms
Kedar V Inamdar, MD, PhD, Dan Jones, MD, PhD
27. Extranodal Lymphomas and Tumors of the Thymus
Brian D Stewart, MD, John T Manning, MD, Dan Jones, MD

Section IV. Stem Cell Transplantation

28. Clinical Aspects of Hematopoietic Stem Cell Transplantation
Elizabeth J Shpall, MD, Marcos de Lima, MD
29. Post-Transplant Molecular Monitoring
Dan Jones, MD, PhD
30. Post-Transplant Immune Function and the Development of Lymphoma
Dequin Ma, MD, PhD and Dan Jones, MD, PhD

Section V. Experimental Hematopathology

31. Hematopoiesis and Stem Cell Biology
Claudiu Cotta, MD, PhD
32. Role of Host Genetics in Lymphoma
Ahmet Dogan, MD, PhD
33. Developing Prognostic Models for Diffuse Large B-Cell Lymphoma
Izidore S Lossos, MD
34. Growth Signaling and Survival Pathways in Aggressive B-Cell Lymphoma
Lan V Pham, PhD, Richard J Ford, MD, PhD
35. Proteomic Profiling and Target Identification in Lymphoma
Megan S Lim, MD, PhD
36. Mouse Models of Lymphoma and Lymphoid Leukemia
M James You, MD, PhD
37. Mouse Models of Myeloid Leukemia
Robert B Lorsbach, MD, PhD
38. Designing Targeted Therapies for Lymphomas and Leukemias

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously
Sort by: Showing 1 Customer Reviews
  • Anonymous

    Posted February 28, 2010

    No text was provided for this review.

Sort by: Showing 1 Customer Reviews

If you find inappropriate content, please report it to Barnes & Noble
Why is this product inappropriate?
Comments (optional)