Nerve and Muscle / Edition 4

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Overview

"Nerve and Muscle is an introductory textbook for students taking university courses in physiology, cell biology or preclinical medicine. Previous editions were highly acclaimed as a readable and concise account of how nerves and muscles work. The book begins with a discussion of the nature of nerve impulses. These electrical events can be understood in terms of the flow of ions through molecular channels in the nerve cell membrane. Then the view changes to consideration of synaptic transmission: how one nerve cell can produce changes in another nerve cell or a muscle fibre with which it makes contact. Again ion channels are involved, but now they are opened by special chemicals released from the nerve cell terminals. The final chapters discuss the nature of muscular contraction, including especially the relations between cellular structure and contractile function. This new edition includes much new material, especially on the molecular nature of ion channels and the contractile mechanism of muscle, while retaining a straightforward exposition of the fundamentals of the subject."--BOOK JACKET.
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Editorial Reviews

From The Critics
Reviewer: George Maeda, PhD (Loma Linda University)
Description: This is one of the few books that provide a highly physiological, experimental perspective on the excitation of nerve and muscle. It is abundantly illustrated with figures from the primary literature highlighting the underpinnings of excitable membrane electrophysiology, intercellular communication, and muscle function. The few updates to this edition include voltage-gated channel molecular structure, skeletal muscle dihydropyridine and ryanodine receptors and smooth muscle activation. The previous edition was published in 1991.
Purpose: The stated objective is to give students a sound foundation in the fundamentals of nerve and muscle function from an experimental viewpoint. The authors have done this by following the pathway of discovery as revealed in the literature of the day, especially in the area of membrane electrophysiology.
Audience: The stated audience for this "introductory account" is university students in physiology, cell biology, and preclinical medicine. While a noble effort is made by these veteran researchers to evoke excitement by looking over the shoulders of giants, students without an adequate knowledge of general physics will probably have to stand on tiptoes to appreciate the view.
Features: The major portion of this book deals with membrane electrophysiology, especially the voltage-gated Na+ and K+ channels, from a classical and molecular perspective. The authors weave their way from the resting membrane clear through to synaptic communication including transmitters and receptors. The molecular basis and mechanical events of skeletal muscle contraction are discussed followed by a comparison of the excitation-contraction process in skeletal, cardiac, and smooth muscle. Some color figures would have been nice, but the low cost of the book helps one overlook this.
Assessment: When comparing this with other books, it is important to note that this is a short, concise, introductory, low cost text specifically on nerve and muscle, not a comprehensive text on neuroscience or neurobiology. The topics are well chosen, discussed, and supported by experimental evidence. Other comparable small books include Katz's Nerve, Muscle and Synapse (McGraw-Hill, 1966) and Junge's Nerve and Muscle Excitation (Sinauer Associates, 1976). A comprehensive, highly focused text on ion channels is Hille's Ionic Channels of Excitable Membranes , 2nd edition (Sinauer Associates, 1992). "
From the Publisher
"Huang has taken on the mammoth task of bringing the book up to date and has succeeded in maintaining the enthusiastic and eminently readable approach of Keynes and Aidley who created one of the greatest physiology books covering the crucial areas of nerve and muscle. The fascinating historical perspective on the discovery of membrane potentials, the transmission of nerve impulses and their molecular basis is essential reading for students of medicine and physiology with a curiosity about scientific methods, and progress. The chapters on muscle - skeletal, cardiac and smooth - show how the concepts elaborated for nerve cells are relevant to contractile tissues, and how the electrical signals are translated into movement. The new edition shows how the important discoveries in the twentieth century remain central today, and the book provides the groundwork for the enormous and exciting task that still lies ahead, namely the understanding of how nerve transmission in the central nervous system is integrated to achieve the higher functions of the human brain, memory, learning and consciousness."
Michael A. Ferenczi, Imperial College London

"This book is a beautifully written gem. It is clearly illustrated, and it makes one of the most difficult areas of biology completely accessible. It should find its way onto the bookshelves of electrophysiologists everywhere and any students who aspire to master one of the most exciting areas of modern biology."
Denis Noble, University of Oxford

"... an excellent summary of the fundamentals of each system and their interactions, while introducing some historic and contemporary experimental evidence on which current understanding is based. Highly recommended."
K.A. Campbell, Choice Magazine


3 Stars from Doody
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Product Details

  • ISBN-13: 9780521519557
  • Publisher: Cambridge University Press
  • Publication date: 1/31/2011
  • Edition number: 4
  • Pages: 194
  • Product dimensions: 7.60 (w) x 9.70 (h) x 0.60 (d)

Meet the Author

Richard D. Keynes is Emeritus Professor of Physiology at the University of Cambridge.

David J. Aidley was Senior Fellow in the School of Biological Sciences at the University of East Anglia, Norwich.

Christopher Huang is Professor of Cell Physiology at the University of Cambridge.

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Table of Contents

1 Structural organization of the nervous system 1
2 Resting and action potentials 11
3 The ionic permeability of the nerve membrane 25
4 Membrane permeability changes during excitation 41
5 Voltage-gated ion channels 59
6 Cable theory and saltatory conduction 73
7 Neuromuscular transmission 86
8 Synaptic transmission in the nervous system 103
9 Skeletal muscles 118
10 The mechanism of contraction in skeletal muscle 136
11 Non-skeletal muscles 156
Further reading 168
References 169
Index 175
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