Nerve-Muscle Interaction

Nerve-Muscle Interaction

by Gerta Vrbova
     
 

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In the second century, Galen recognized that nerve and muscle were functionally inseparable since contraction of muscle occurred only if the nerves supplying that muscle were intact. He therefore concluded that the shortening of a muscle was controlled by the central nervous sytem while the extension of a muscle could occur in the absence of innervation. Nerves, he

Overview

In the second century, Galen recognized that nerve and muscle were functionally inseparable since contraction of muscle occurred only if the nerves supplying that muscle were intact. He therefore concluded that the shortening of a muscle was controlled by the central nervous sytem while the extension of a muscle could occur in the absence of innervation. Nerves, he thought, were the means of transport for animal spirits to the muscles; the way in which animal spirits may bring about contraction dominated the study of muscle physiology from that time until the historical discovery of Galvani that muscle could be stimulated electrically and that nerve and muscle were themselves a source of electrical energy. It is now well known that nerves conduct electrically and that transmission from nerve to striated muscle is mediated by the chemical which is liberated from nerve terminals onto the muscle membrane. In vertebrates this chemical is acetylcholine (ACh). Thus the concept of spirits that are released from nerves and control muscle contraction directly, is no longer tenable. Nevertheless the concept of 'substances' transported down nerv~s which directly control many aspects of muscle has not been abandoned, and has in fact been frequently reinvoked to account for the long-term regula­ tion of many characteristics of muscle (see review by Gutmann, 1976) and for the maintenance of its structural integrity.

Editorial Reviews

Booknews
An advanced review of the interactions between motorneurones and muscles in vertebrates, integrating results from various disciplines. Covers the development of motorneurones and muscles; the significance of nerve-muscle interactions for the development of the neuromuscular systems; tonic and phasic muscle fibers of birds; nerve regeneration and muscle reinnervation; and the importance of neuromuscular activity in development. For researchers, neurophysiologists, and pathologists. Includes b&w photos and diagrams. Annotation c. Book News, Inc., Portland, OR (booknews.com)
From the Publisher
'A small book, but full with many precise details of the higher interest for the specialists in myology and neurology.'
Cellular and Molecular Biology
'This is an excellent reference source and would be a valuable purchase for libraries and those involved in neuromuscular research.'
Physiotherapy Journal

Product Details

ISBN-13:
9780412157202
Publisher:
Springer Netherlands
Publication date:
01/28/1978
Pages:
233
Product dimensions:
0.00(w) x 0.00(h) x (d)

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