Neural Development and Stem Cells / Edition 2

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"For this new edition of his work, Mahendra S. Rao, has assembled a panel of leading experts to expand and update his Stem Cells and CNS Development to reflect the enormous increase in our knowledge of the development of the nervous system. Working from a new understanding that the regionalization of stem cells occurs early in development and that this bias appears to persist even after prolonged culture, Dr. Rao has added additional chapters on olfactory epithelial stem cells and retinal stem cells, both of which differ in their properties from ventricular zone and subventricular zone-derived neural stem cells. A new chapter on cell death summarizes the important changes in the death pathway that occur as stem cells mature. Special attention is paid to the derivation of neural cells from embryonic stem cells. All chapters from the first edition have been extensively revised and updated. Appendices provide information on neural stem cell companies, stem cells and transplants, patents and stem cells, and US federal government guidelines on stem cells." Wide-ranging and up-to-date, Neural Development and Stem Cells, Second Edition provides neuroscientists with an authoritative guide to stem cells in the nervous system, tracing with great clarity the development of stem cells from differentiation to neurons, astrocytes, and oligodendrocytes.
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Product Details

  • ISBN-13: 9781588294814
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 9/15/2005
  • Series: Contemporary Neuroscience Series
  • Edition number: 2
  • Pages: 468
  • Product dimensions: 7.30 (w) x 10.20 (h) x 1.20 (d)

Meet the Author

Mahendra S. Rao, MD, Ph.D

Dr. Rao is internationally renowned for his research involving human embryonic stem cells (hESCs) and other somatic stem cells. He has worked in the stem cell field for more than 20 years, with stints in academia, government and regulatory affairs and industry. He received his M.D. from Bombay University in India and his Ph.D. in developmental neurobiology from the California Institute of Technology, Pasadena. Following postdoctoral training at Case Western Reserve University, Cleveland, he established his research laboratory in neural development at the University of Utah, Salt Lake City. He next joined the National Institute on Aging as chief of the Neurosciences Section, where he studied neural progenitor cells and continued to explore his longstanding interest in their clinical potential. He then spent six years as the vice president of Regenerative Medicine at Life Technologies, Carlsbad, Calif. Most recently, he returned in August 2011 to the National Institutes of Health (NIH), as Director of the new NIH Center for Regenerative Medicine (NIH CRM). He co-founded Q Therapeutics, a neural stem cell company based in Salt Lake City. He also served internationally on advisory boards for companies involved in stem cell processing and therapy, on committees including the U.S. Food and Drug Administration’s Cellular Tissue and Gene Therapies Advisory Committee chair, and as the California Institute of Regenerative Medicine and International Society for Stem Cell Research liaison to the International Society for Cellular Therapy.

Melissa Carpenter, Ph. D.

For the last 17 years, Dr. Carpenter has worked on the development of cell therapies using human adult and embryonic stem cells, in academia and industry, in the United States and Canada. She has been involved with human embryonic stem cell (hESC) research since the field was established. Her work involves discovery research and the translation of this research into therapeutics, including developing strategies for preclinical development and navigating the regulatory issues surrounding stem cell therapies. She has held leadership positions at 3 of the major stem cell companies: CytoTherapeutics, Inc (StemCells, Inc), Geron, Corp., and Novocell, Inc (Viacyte, Inc). Currently Dr. Carpenter is President of Carpenter Group Consulting and works with early stage companies, academic groups and investors to translate discovery based research into stem cell therapies. She is credited with numerous publications and patents in the stem cell field.

Mohan C. Vemuri, Ph.D.

Dr. Vemuri is currently the Director, Research and Development of Stem Cells and Regenerative Medicine at Life Technologies. He has been with the company since 2006 in different R&D leadership roles and instrumental in stem cell based product development for human pluripotent (embryonic and iPSC) and adult stem cells in cGMP regulated conditions for research and cell therapy. Dr. Vemuri has served as faculty and staff at Children’s Hospital of Philadelphia (University of Pennsylvania) and worked on enhancing hematopoietic stem cell engraftment and immune reconstitution utilizing gene engineering technology. Dr. Vemuri was also responsible for designing stem cell based assays and lead drug discovery effort for Parkinson’s disease in GLP settings at Thomas Jefferson University. Dr. Vemuri is a recipient of National Institutes of Health Fogarty Fellowship award and best investigator award and a citation for deriving hESC from the Association of Reproductive Medicine for the year 2005. Dr. Vemuri hasheld scientific positions in University of Hyderabad, Thomas Jefferson University, and University College of Sciences in Philadelphia. Dr. Vemuri has authored over 50 publications in peer reviewed journals,and edited three books,1) Stem Cell Assays 2. Regulatory Networks in Stem Cells and 3., MSC Assays and Applications, by Springer/Humana Press. Dr. Vemuri presently works and collaborates with different investigators towards the successful utilization of stem cells in regenerative cell therapies in a regulatory compliant environment.

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Table of Contents

1 Defining neural stem cells and their role in normal development of the nervous system 1
2 Neural stem cells in the adult brain : implications of their glial characteristics 29
3 Cellular and molecular properties of multipotent neural stem cells throughout ontogeny 49
4 Multipotent stem cells in the embryonic nervous system 67
5 Regulation of neural stem cell death 97
6 Neuronal progenitor cells of the mammalian neonatal anterior subventricular Zone 123
7 Glial restricted precursors 143
8 PNS precursor cells in development and cancer 189
9 Stem cells of the adult olfactory epithelium 219
10 Retinal stem cells 235
11 Transdifferentiation in the nervous system 249
12 Neural progenitor cells of the adult human brain 267
13 Embryonic stem cells and neurogenesis 299
14 Mobilizing of neural precursors in the adult central nervous system 343
15 Neural stem cells and transplant therapy : intrinsic programs and clinical applications 371
App. A Neural stem cell companies 421
App. B Stem cells and transplants 425
App. C Patents and stem cells 429
App. D Stem cells and US federal guidelines 431
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