Neural Repair, Transplantation and Rehabilitation

Overview

This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as ...

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Overview

This book begins with a synopsis of experimental work underlying degeneration and recovery in the nervous system, which is then discussed in the context of strategies to repair the central nervous system (CNS) and peripheral nervous system (PNS). The major part of the book is given over to the approach involving the use of transplanted tissues to replace and restore disrupted neural networks. This experimental work has formed the basis for the emerging clinical trials employing neural grafts for diseases such as Parkinson's and Huntington's, which are discussed in detail. The book then goes on to discuss newer cellular strategies involving the manipulation of neural cells both in culture and genetically, an approach that may ultimately be employed in the clinical situation.
Neural Repair, Transplantation and Rehabilitation is unique in bridging the gap from experimental studies to clinical trials, whilst also providing the non-specialist with a background in rehabilitation strategies as well as basic neuroscience. It is recommended for all those involved in the management of patients with degenerative and traumatic injuries to the nervous system.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Daniel B. Hier, MD (University of Illinois at Chicago College of Medicine)
Description: This is a well-written, clear, and highly readable review of the potential for neural repair and transplantation to enhance recovery after damage to the nervous system.
Purpose: This book is coauthored by two investigators from the Centre for Brain Repair in Cambridge, England. They seek to introduce the principles underlying the emerging field of neural transplantation for neurological illnesses.
Audience: The primary audience is clinically active rehabilitation specialists such as physiatrists, neurologists, speech pathologists, neuropsychologists, physical therapists, and occupational therapists.
Features: There are three superb introductory chapters on regeneration in the nervous system, strategies for repair and protection of the CNS, and principles of neural transplantation. In subsequent chapters the potential role of neural transplantation in Parkinson's disease, Huntington's disease, Alzheimer's disease, and spinal cord injury is examined.
Assessment: This book is a pleasure to read. It is clear, informative, and well-written. It introduces a complex subject in a lucid fashion for both physicians and non-physicians. Important issues in the field of neurorehabilitation are addressed with special emphasis on the emerging technique of neural transplantation. I highly recommend this book to any rehabilitation professional from psychologist to neurologist who is interested in the future of neurorehabilitation.
Daniel B. Hier
This is a well-written, clear, and highly readable review of the potential for neural repair and transplantation to enhance recovery after damage to the nervous system. This book is coauthored by two investigators from the Centre for Brain Repair in Cambridge, England. They seek to introduce the principles underlying the emerging field of neural transplantation for neurological illnesses. The primary audience is clinically active rehabilitation specialists such as physiatrists, neurologists, speech pathologists, neuropsychologists, physical therapists, and occupational therapists. There are three superb introductory chapters on regeneration in the nervous system, strategies for repair and protection of the CNS, and principles of neural transplantation. In subsequent chapters the potential role of neural transplantation in Parkinson's disease, Huntington's disease, Alzheimer's disease, and spinal cord injury is examined. This book is a pleasure to read. It is clear, informative, and well-written. It introduces a complex subject in a lucid fashion for both physicians and non-physicians. Important issues in the field of neurorehabilitation are addressed with special emphasis on the emerging technique of neural transplantation. I highly recommend this book to any rehabilitation professional from psychologist to neurologist who is interested in the future of neurorehabilitation.

5 Stars! from Doody
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Product Details

Table of Contents

The Limits of Regeneration in the Central Nervous System. Strategies for Protection and Repair of Damage in the CNS. Experimental Principles of Neural Transplantation. Nigral Grafts in Animal Models of Parkinson's Disease. First Clinical Trials: Neural Grafts in Parkinson's Disease. Striatal Grafts: Circuit Reconstruction and Huntington's Disease. Alzheimers Disease: A Difficult Target for Transplantation. Spinal Cord Injury: The Ultimate Challenge. Other Sources of Cells for Transplantation, Psychological Factors in Graft Function.

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