Neural Signaling: Opportunities for Novel Diagnostic Approaches and Therapies / Edition 1

Paperback (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $42.31
Usually ships in 1-2 business days
(Save 71%)
Other sellers (Paperback)
  • All (3) from $42.31   
  • Used (3) from $39.16   
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any coupons and promotions
Seller since 2006

Feedback rating:



New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

Very Good
264 pp., Paperback, minor wear to head of spine, hand stamp to half-title page else very good

Ships from: Cleveland, OH

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
  • Express, 48 States
  • Express (AK, HI)
Seller since 2010

Feedback rating:


Condition: Like New
Like New Ships from the UK. Book in almost Brand New condition. Your purchase also supports literacy charities. *****PLEASE NOTE: This item is shipping from an authorized seller ... in Europe. In the event that a return is necessary, you will be able to return your item within the US. To learn more about our European sellers and policies see the BookQuest FAQ section***** Read more Show Less

Ships from: Dunfermline, United Kingdom

Usually ships in 1-2 business days

  • Canadian
  • Standard, 48 States
  • Standard (AK, HI)
Seller since 2015

Feedback rating:


Condition: Good
Buy with Confidence. Excellent Customer Support. We ship from multiple US locations. No CD, DVD or Access Code Included.

Ships from: Fort Mill, SC

Usually ships in 1-2 business days

  • Standard, 48 States
Page 1 of 1
Showing All
Sort by

More About This Textbook


Low-molecular-weight chemicals, which are produced and secreted by neurons and a limited range of non-neural cells, are the major vehicles for communication of nerve cells with each other and with neurally controlled non-neural cells. Research over the past several decades has identified a wide spectrum of such neuromediators, delineated their structures, elucidated pathways of biosynthesis and biodegradation, and determined the processes of development and function that they influence physiologically. These results have revealed the nature of cellular receptors that recognize neuromediators selectively and the pathways that transduce signals from neuromediator-occupied receptors to the target cells. For most neuromediators and their receptors, pharmacological agonists and antagonists of high specificity also have been discovered or designed and synthesized.

In the past decade, a broad range of animal models has been developed in which modern genetic methods have allowed overexpression and deletion of neuromediators and/or of their receptors for sophisticated analyses of their roles in normal physiology and some diseases. The availability of pharmacological agents directed to neuromediators or their receptors also has stimulated early studies of the involvement of these systems in some human diseases. At the same time as these revolutionary advances, most established conference series dedicated to this subject area have become narrower and have focused more sharply on individual neuromediators to permit deeper and more penetrating presentations and discussions.

At this time, it seems appropriate to organize a volume that examines the conceptual, methodological, and practical progress in the field from broader biological and pathophysiological perspectives. This volume describes a new international conference in the integrated field of neuromediators that has no predecessors and is set in a biomedical context of possible diagnostic and therapeutic approaches.

NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit

ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order ( Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit for more information about becoming a member

Read More Show Less

Product Details

Table of Contents

Part I: New Biology of Cellular Receptors for Neuromediators: Regulation of Expression, Signal Transduction, and Mechanisms of Cross-talk:.

1. G Protein-coupled Receptor Structures, Molecular Associations, and Modes of Regulation: Laurence J. Miller.

2. Discovery of PACAP-regulated Genes through Microarray Analyses in Cell Culture and in Vivo: Lee E. Eiden, Babru Samal, Matthew J. Gerdin, Tomris Mustafa, and Nikolas Stroth.

3. Monitoring the State of Cholecystokinin Receptor Oligomerization after Ligand Binding Using Decay of Time-resolved Fluorescence Anisotropy: Kaleeckal G. Harikumar and Laurence J. Miller.

4. Role of Pituitary Adenylate Cyclase Activating Polypeptide in the Pancreatic Endocrine System: Bo Ahrén.

5. PTHrP Regulates Gli Transcriptional Activation: Lessons Learned from Bone Development and Cartilage Neoplasia: Benjamin A. Alman and Jay S. Wunder.

6. Molecular Mechanisms of TRPV4-Mediated (neural) Signaling: Wolfgang Liedtke.

7. The Sall2 Transcription Is a Novel p75NTR Binding Protein That Promotes the Development and Function of Neurons: Roxana Pincheira and David B. Donner.

Part II: Neuromediator Participation in Host Defense, Immunity, and Inflammation:.

8. Diverse Mechanisms and Consequences of Immunoadoption of Neuromediator Systems: Edward J. Goetzl, Robert C. Chan, Mahesh Yadav.

9. Substance P in Stress and Anxiety: NK1 Receptor Antagonism Interacts with Key Brain Areas of the Stress Circuitry: Karl Ebner, Patrik Muigg, Georg Singewald, Nicolas Singewald.

10. Mast Cells Stimulate Activated T Cells: Implications for Multiple Sclerosis: Theoharis C. Theoharides, Duraisamy Kempuraj, Taxiarchis Kourelis Akrivi Manola.

11. VIP-mediated Th17 Differentiation: An Expanding Spectrum of VIP Effects in Immunity and Autoimmunity: Mahesh Yadav and Edward J. Goetzl.

12. Neurokinin-1 Receptor Expression and Function Macrophages and Brain- Role in HIV Neuropathogenesis – (Perspective): Steven D. Douglas, Jian-Ping Lai, Florin Tuluc, Lynnae Schwartz, and Laurie E. Kilpatrick.

Part III: Neuromediators in Diseases:.

13. Glutamate and Neurotrophic Factors in Neuronal Plasticity and Disease: Mark P. Mattson.

14. Diversity of Neuropathogenic Mechanisms and Implications of Neuromediation of Diseases: Susan E Leeman.

15. Inhibitory Effects of a Neurokinin-1 Receptor Antagonist on Postoperative Peritoneal Adhesion Formation: Karen L. Reed, Arthur F. Stucchi, Susan E. Leeman, and James M. Becker.

16. Neuropeptides, Mesenteric Fat, and Intestinal Inflammation: Iordanes Karagiannides and Charalabos Pothoulakis.

17. Gastrin-Releasing Peptide, Immune Responses, and Lung Disease: Simone Degan, Giselle Y. Lopez, and Mary E. Sunday.

18. The VIP Gene Is a Key Modulator of Pulmonary Vascular Remodeling and Inflammation: Sami I. Said.

Part IV: Neuromediators in Prenatal Development and Stress:.

19. Prenatal Alcohol Exposure Increases Vulnerability to Stress and Anxiety-like Disorders in Adulthood: Kim G.C. Hellemans, Pamela Verma, Esther Yoon, Wayne Yu, and Joanne Weinberg.

20. Role of Various Neurotransmitters in Mediating the Long-term Endocrine Consequences of Prenatal Alcohol Exposure: Soon Lee, Irene Choi, Sang Kang and Catherine Rivier.

21. Perinatal Maternal Fat Intake Affects Metabolism and Hippocampal Function in the Offspring: A Potential Role for Leptin: Claire-Dominique Walker, Lindsay Naef, Esterina d’Asti, Hong Long, Zhifang Xu, Alain Moreau, and Bouziane Azeddine.

Part V: Diagnostic and Therapeutic Strategies for Neuromediators in Diseases:.

22. Informed Development of Drugs Acting at Family B G Protein-coupled Receptors: Laurence J. Miller.

23. Experimental Therapeutic Strategies for Severe Sepsis: Mediators and Mechanisms: William R. Parrish, Margot Gallowitsch-Puerta, Christopher J. Czura, and Kevin J. Tracey.

24. A New Hypothesis: Activation of the Pro-opiomelanocortin Gene with Ketoconazole as a Treatment for Parkinson’s Disease: Alberto Halabe Bucay.

25. Opportunities and Challenges in the Discovery of New Central Nervous System Drugs: James E. Krause and Bertrand L. Chenard.

26. Molecular Imaging to Biomarker Development in Neuroscience: J. James Frost.

27. Studying the Brain Gut Axis with Pharmacological Imaging: Kirsten Tillisch, Zhuo Wang, Lisa Kilpatrick, Daniel P. Holschneider, and Emeran A. Mayer.

Index of Contributors

Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)