Neural Stem Cells for Brain and Spinal Cord Repair / Edition 1

Neural Stem Cells for Brain and Spinal Cord Repair / Edition 1

by Tanja Zigova
     
 

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ISBN-10: 1588290034

ISBN-13: 9781588290038

Pub. Date: 11/28/2002

Publisher: Springer-Verlag New York, LLC

Neural Stem Cells for Brain and Spinal Cord Repair focuses on developments in the rapidly growing area of manipulations/utilization of the neural stem/progenitor cells for the therapeutic purposes as well as basic research that is leading to clinical applications. This text is divided into three sections. Section one offers a prospective on the historical

Overview

Neural Stem Cells for Brain and Spinal Cord Repair focuses on developments in the rapidly growing area of manipulations/utilization of the neural stem/progenitor cells for the therapeutic purposes as well as basic research that is leading to clinical applications. This text is divided into three sections. Section one offers a prospective on the historical development of this field and characterizes it's contemporary/current and future roles in neural stem science. This part also reviews basic definitions, sources of stem cells and methods of their expansion as well as mechanisms involved in stem cell differentiation including molecular control of neurogenesis, the role of cytokine signaling proteins and epigenetic regulation of neurotransmitter phenotype. Section two brings the latest updates in rodent studies unveiling the possibilities to boost up/mobilize the existing stem/progenitor cell pools in the brain using various models. This section also goes into detail on the most recent results on usage of neural stem cells for rodent models of spinal cord injuries. The last section in the text features articles for using human neural stem cells. Also covered are findings on recent advances in human bone marrow cell research as an additional, readily available source for auto- and allografting of neural precursors for therapies ranging from gene replacement to neural reconditioning in neurodegenerative diseases, stroke and trauma. Also contained within this informative conclusion is a brief look at laboratory growth neurons used to correct neurological deficits caused by stroke, which led to the first human stroke transplant trial.

Product Details

ISBN-13:
9781588290038
Publisher:
Springer-Verlag New York, LLC
Publication date:
11/28/2002
Series:
Contemporary Neuroscience Series
Edition description:
2003
Pages:
434
Product dimensions:
5.98(w) x 9.02(h) x 0.04(d)

Table of Contents

Part I. Stem Cells for and from the CNS: Their Source and Fundamental Properties

Sources of Cells for CNS Therapy
Melissa K. Carpenter, Mark Mattson, and Mahendra S. Rao

Neural Stem Cells and Their Plasticity
Angela Gritti, Angelo Vescovi, and Rossella Galli

Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells
Martha Windrem, Neeta Roy, Marta Nunes, and Steven A. Goldman

Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells
Eiji Nakagawa, Kozo Hatori, Atsushi Nagai, Hyun B. Choi, Myung A. Lee, Jung H. Bang, Jean Kim, Jae K. Ryu, Akihiko Ozaki, Min C. Lee, Evan Y. Snyder, and Seung U. Kim

The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood
Shijie Song, Paul Sanberg, and Juan Sanchez-Ramos

Part II. In Vitro and/or In Vivo Manipulations of Stem/Progenitor Cells for the CNS

Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation
Luciano Conti and Elena Cattaneo

Neural Stem/Progenitor Cell Clones or 'Neurospheres': A Model for Understanding Neuromorphogenesis
Dennis A. Steindler, Bjorn Scheffler, Eric D. Laywell, Oleg N. Suslov, Tong Zheng, Thomas Reiniger, and Valery G. Kukekov

Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives
Marcel M. Daadi

Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair
Sanjay S. P. Magavi and Jeffrey D. Macklis

Neural Stem Cells in the Adult Hippocampus
Jasodhara Ray and Daniel A. Peterson

Part III. Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNS

Global Gene and Cell Replacement Strategies via Stem Cells
Kook In Park, James J. Palacino, Roseanne Taylor, Karen S. Aboody, Barbara A. Tate, Vaclav Ourednik, Jitka Ourednik, Mahesh Lachyankar, and Evan Y. Snyder

Neural Stem Cells in and from the Spinal Cord, Yang D. Teng, Mary Katherine C. White, Erin Lavik, Shaoxiang Liu, Mahesh Lachyankar, Kook In Park, and Evan Y. Snyder

Stem Cells for Spinal Cord Injury, Paul Lu, Evan Y. Snyder, and Mark H. Tuszynski

Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally Grafted Neural Precursors and Human hNT Neurons
Martin Marsala, Osamu Kakinohana, Tony L. Yaksh, and Joho Tokumine

Utilization of Marrow Stromal Cells for Gene Transfer into the CNS
S. Ausim Azizi, Emily J. Schwarz, Darwin Prockop, Guillermo Alexander, Katherine A. Mortati, and Barbara Krynska

Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy
Cesario V. Borlongan and Paul R. Sanberg

Index

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