Neural Stem Cells for Brain and Spinal Cord Repair / Edition 1

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Overview

Neural Stem Cells for Brain and Spinal Cord Repair focuses on developments in the rapidly growing area of manipulations/utilization of the neural stem/progenitor cells for the therapeutic purposes as well as basic research that is leading to clinical applications. This text is divided into three sections. Section one offers a prospective on the historical development of this field and characterizes it's contemporary/current and future roles in neural stem science. This part also reviews basic definitions, sources of stem cells and methods of their expansion as well as mechanisms involved in stem cell differentiation including molecular control of neurogenesis, the role of cytokine signaling proteins and epigenetic regulation of neurotransmitter phenotype. Section two brings the latest updates in rodent studies unveiling the possibilities to boost up/mobilize the existing stem/progenitor cell pools in the brain using various models. This section also goes into detail on the most recent results on usage of neural stem cells for rodent models of spinal cord injuries. The last section in the text features articles for using human neural stem cells. Also covered are findings on recent advances in human bone marrow cell research as an additional, readily available source for auto- and allografting of neural precursors for therapies ranging from gene replacement to neural reconditioning in neurodegenerative diseases, stroke and trauma. Also contained within this informative conclusion is a brief look at laboratory growth neurons used to correct neurological deficits caused by stroke, which led to the first human stroke transplant trial.

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Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: The progress in research on neural stem cells is promoting the development of new ideas in surgical applications for management of neurodegenerative diseases. This book addresses current research protocols for neural stem cells and future applications for each of the protocols described.
Purpose: The purpose is to address research protocols and possible future applications of neural stem cells in clinical practice. The author has met the objectives.
Audience: The audience is primarily neuroscientists, neurologists, and neurosurgeons who, looking for novel modalities of treatment of their patients, may envision in this research an opportunity for better disease management. The authors are certainly credible authorities in the field.
Features: The 64 authors contribute 16 chapters in this book. Starting from the basic aspects of cell culturing, this book emphasizes the different available research protocols that are currently being used for possible management of neurological degenerative diseases. In addition, molecular mechanisms of interaction are always explained whenever necessary. There is not much discussion of the possible surgical applications of neural stem cells, as most authors are from the clinical or basic science arena.
Assessment: This book is a perfect purchase for neurologists and neuroscientists. Neurosurgeons with a basic science interest would also find this a useful acquisition.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781588290038
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/28/2002
  • Series: Contemporary Neuroscience Series
  • Edition description: 2003
  • Edition number: 1
  • Pages: 434
  • Product dimensions: 6.20 (w) x 9.20 (h) x 1.00 (d)

Table of Contents

Dedications
Preface
Contributors
Pt. I Stem Cells for and from the CNS: Their Source and Fundamental Properties
1 Sources of Cells for CNS Therapy 3
2 Neural Stem Cells and Their Plasticity 45
3 Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells 69
4 Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells
5 The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood 107
Pt. II In Vitro and / or In Vivo Manipulations of Stem/Progenitor Cells for the CNS
6 Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation 135
7 Neural Stem/Progenitor Cell Clones or "Neurospheres": A Model for Understanding Neuromorphogenesis 183
8 Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives 203
9 Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair 229
10 Neural Stem Cells in the Adult Hippocampus 269
Pt. III Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNS
11 Global Gene and Cell Replacement Strategies via Stem Cells
12 Neural Stem Cells in and from the Spinal Cord 333
13 Stem Cells for Spinal Cord Injury 347
14 Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally Grafted Neural Precursors and Human hNT Neurons 367
15 Utilization of Marrow Stromal Cells for Gene Transfer into the CNS 395
16 Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy 411
Index 431
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