Neural Stem Cells for Brain and Spinal Cord Repair / Edition 1

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Overview

Active neuroscientists survey NSCs as potential tools for central nervous system and spinal cord repair by explaining their clinically significant fundamental properties, manipulations, and potential therapeutic paradigms. Their discussion of the fundamental biology of NSCs illustrates the signaling pathways that regulate stem cell division and differentiation, and defines the methods of NSC expansion and propagation, neuromorphogenesis, the factors determining cell fate both in vitro and in situ, and the induction of self-reparative processes within the brain. They also present strategies that may lead to fruitful clinical applications in the near future. These range from the replacement of degenerated, dysfunctional, or maldeveloped cells to the provision of factors that may protect, correct, recruit, promote self-repair, or mediate the connectivity of host cells.

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Editorial Reviews

From The Critics
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: The progress in research on neural stem cells is promoting the development of new ideas in surgical applications for management of neurodegenerative diseases. This book addresses current research protocols for neural stem cells and future applications for each of the protocols described.
Purpose: The purpose is to address research protocols and possible future applications of neural stem cells in clinical practice. The author has met the objectives.
Audience: The audience is primarily neuroscientists, neurologists, and neurosurgeons who, looking for novel modalities of treatment of their patients, may envision in this research an opportunity for better disease management. The authors are certainly credible authorities in the field.
Features: The 64 authors contribute 16 chapters in this book. Starting from the basic aspects of cell culturing, this book emphasizes the different available research protocols that are currently being used for possible management of neurological degenerative diseases. In addition, molecular mechanisms of interaction are always explained whenever necessary. There is not much discussion of the possible surgical applications of neural stem cells, as most authors are from the clinical or basic science arena.
Assessment: This book is a perfect purchase for neurologists and neuroscientists. Neurosurgeons with a basic science interest would also find this a useful acquisition.

3 Stars from Doody
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Product Details

  • ISBN-13: 9781588290038
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/28/2002
  • Series: Contemporary Neuroscience Series
  • Edition description: 2003
  • Edition number: 1
  • Pages: 434
  • Product dimensions: 6.20 (w) x 9.20 (h) x 1.00 (d)

Table of Contents

Dedications
Preface
Contributors
Pt. I Stem Cells for and from the CNS: Their Source and Fundamental Properties
1 Sources of Cells for CNS Therapy 3
2 Neural Stem Cells and Their Plasticity 45
3 Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells 69
4 Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells
5 The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood 107
Pt. II In Vitro and / or In Vivo Manipulations of Stem/Progenitor Cells for the CNS
6 Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation 135
7 Neural Stem/Progenitor Cell Clones or "Neurospheres": A Model for Understanding Neuromorphogenesis 183
8 Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives 203
9 Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair 229
10 Neural Stem Cells in the Adult Hippocampus 269
Pt. III Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNS
11 Global Gene and Cell Replacement Strategies via Stem Cells
12 Neural Stem Cells in and from the Spinal Cord 333
13 Stem Cells for Spinal Cord Injury 347
14 Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally Grafted Neural Precursors and Human hNT Neurons 367
15 Utilization of Marrow Stromal Cells for Gene Transfer into the CNS 395
16 Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy 411
Index 431
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