Neural Stem Cells for Brain and Spinal Cord Repair / Edition 1

Hardcover (Print)
Buy New
Buy New from
Used and New from Other Sellers
Used and New from Other Sellers
from $20.00
Usually ships in 1-2 business days
(Save 92%)
Other sellers (Hardcover)
  • All (10) from $20.00   
  • New (8) from $91.66   
  • Used (2) from $20.00   


Neural Stem Cells for Brain and Spinal Cord Repair focuses on developments in the rapidly growing area of manipulations/utilization of the neural stem/progenitor cells for the therapeutic purposes as well as basic research that is leading to clinical applications. This text is divided into three sections. Section one offers a prospective on the historical development of this field and characterizes it's contemporary/current and future roles in neural stem science. This part also reviews basic definitions, sources of stem cells and methods of their expansion as well as mechanisms involved in stem cell differentiation including molecular control of neurogenesis, the role of cytokine signaling proteins and epigenetic regulation of neurotransmitter phenotype. Section two brings the latest updates in rodent studies unveiling the possibilities to boost up/mobilize the existing stem/progenitor cell pools in the brain using various models. This section also goes into detail on the most recent results on usage of neural stem cells for rodent models of spinal cord injuries. The last section in the text features articles for using human neural stem cells. Also covered are findings on recent advances in human bone marrow cell research as an additional, readily available source for auto- and allografting of neural precursors for therapies ranging from gene replacement to neural reconditioning in neurodegenerative diseases, stroke and trauma. Also contained within this informative conclusion is a brief look at laboratory growth neurons used to correct neurological deficits caused by stroke, which led to the first human stroke transplant trial.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Celso Agner, MD, MS, MSc (Michigan Neurology Partners)
Description: The progress in research on neural stem cells is promoting the development of new ideas in surgical applications for management of neurodegenerative diseases. This book addresses current research protocols for neural stem cells and future applications for each of the protocols described.
Purpose: The purpose is to address research protocols and possible future applications of neural stem cells in clinical practice. The author has met the objectives.
Audience: The audience is primarily neuroscientists, neurologists, and neurosurgeons who, looking for novel modalities of treatment of their patients, may envision in this research an opportunity for better disease management. The authors are certainly credible authorities in the field.
Features: The 64 authors contribute 16 chapters in this book. Starting from the basic aspects of cell culturing, this book emphasizes the different available research protocols that are currently being used for possible management of neurological degenerative diseases. In addition, molecular mechanisms of interaction are always explained whenever necessary. There is not much discussion of the possible surgical applications of neural stem cells, as most authors are from the clinical or basic science arena.
Assessment: This book is a perfect purchase for neurologists and neuroscientists. Neurosurgeons with a basic science interest would also find this a useful acquisition.

3 Stars from Doody
Read More Show Less

Product Details

  • ISBN-13: 9781588290038
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 11/28/2002
  • Series: Contemporary Neuroscience Series
  • Edition description: 2003
  • Edition number: 1
  • Pages: 434
  • Product dimensions: 6.20 (w) x 9.20 (h) x 1.00 (d)

Table of Contents

Pt. I Stem Cells for and from the CNS: Their Source and Fundamental Properties
1 Sources of Cells for CNS Therapy 3
2 Neural Stem Cells and Their Plasticity 45
3 Identification, Selection, and Use of Adult Human Oligodendrocyte Progenitor Cells 69
4 Generation, Characterization, and Transplantation of Immortalized Human Neural Crest Stem Cells
5 The Search for Neural Progenitors in Bone Marrow and Umbilical Cord Blood 107
Pt. II In Vitro and / or In Vivo Manipulations of Stem/Progenitor Cells for the CNS
6 Signal Transduction Pathways That Regulate Neural Stem Cell Division and Differentiation 135
7 Neural Stem/Progenitor Cell Clones or "Neurospheres": A Model for Understanding Neuromorphogenesis 183
8 Neural Stem Cells and Specification of Cell Fates: Biological and Therapeutical Perspectives 203
9 Manipulation of Neural Precursors In Situ: Potential for Brain Self-Repair 229
10 Neural Stem Cells in the Adult Hippocampus 269
Pt. III Stem/Progenitor Cells in Representative Therapeutic Paradigms for the CNS
11 Global Gene and Cell Replacement Strategies via Stem Cells
12 Neural Stem Cells in and from the Spinal Cord 333
13 Stem Cells for Spinal Cord Injury 347
14 Spinal Ischemia-Induced Paraplegia: A Potential Therapeutical Role of Spinally Grafted Neural Precursors and Human hNT Neurons 367
15 Utilization of Marrow Stromal Cells for Gene Transfer into the CNS 395
16 Preclinical Basis for Use of NT2N Cells in Neural Transplantation Therapy 411
Index 431
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star


4 Star


3 Star


2 Star


1 Star


Your Rating:

Your Name: Create a Pen Name or

Barnes & Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation


  • - By submitting a review, you grant to Barnes & and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Terms of Use.
  • - Barnes & reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)