This book is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. ...
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Neurobiology of Disease

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This book is aimed at any basic scientist or clinician scientist teaching a course or conducting research on the basic science underlying the major neurological diseases. It provides an excellent overview of cutting-edge research on the fundamental disorders of the nervous system, including physiological and molecular aspects of dysfunction. The major categories of neurological disease are covered, and the chapters provide specific information about particular diseases exemplifying each of these categories. Sufficient clinical information is included to put into perspective the basic mechanisms discussed. The book assembles a world-class team of section editors and chapters written by acknowledged experts in their respective fields.

* Provides cutting edge information about fundamental mechanisms underlying neurological diseases
* Amply supplied with tables, illustrations and references
* Includes supporting clinical information putting the mechanisms of disease into perspective
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Editorial Reviews

Doody's Review Service
Reviewer: George F Wittenberg, M.D., Ph.D.(University of Maryland School of Medicine)
Description: This unique textbook, a selective review of neuropathophysiology for the neuroscientist, aims at presenting many neurological disorders along with the science underlying their etiology and treatment.
Purpose: The purpose of this book is to provide basic neuroscientists with a comprehensive view of the mechanisms underlying specific neurological diseases. This is not only a worthy objective, it is unfulfilled by any other book, to my knowledge. The objectives are met by the formula applied by the section editors. It does not cover everything, but it does cover all common disorders as well as those thought to be of particular interest.
Audience: The book is squarely aimed at neuroscience graduate students, and would also be a good source of clinical and pathophysiological information for a translational scientist. The editor, section editors, and contributors are all authorities in their fields.
Features: It starts off with lysosomal disorders, which is a little jarring, but the book is organized into central and peripheral disorders, with the central disorders subdivided mainly by disease etiologies (neoplastic, vascular, etc.) One section covers imaging methods, which is very helpful, given their importance in both clinical diagnosis and research. Peripheral disorders (nerve and muscle) receive somewhat short shrift, particularly as both central and peripheral pain syndromes are included in this half of the text. Cerebrovascular disease is well covered, including vascular dementia and recovery of function after stroke. Pediatric disorders are well covered, including developmental syndromes, and selected genetic and metabolic disorders. Multiple sclerosis gets a fairly short chapter, and leaves one with a sense of frustration about the disorder, which is probably appropriate. Color illustrations and other graphic elements in each chapter give the students a take-home message. Although the stated purpose limited topics to neurology, psychiatric disorders are not covered, with a few exceptions on the extensive border between psychiatry and neurology (e.g. attention-deficit hyperactivity).
Assessment: For five years I was course director of clinical neuroscience, a course for neuroscience program graduate students, the intent of which was to expose students to the broad range of clinical problems where gaps in knowledge limited clinical practice. This exposure provides clinical context for students who already have an intellectual interest. It also facilitates collaboration, and ultimately, translational research. The problem that I faced five years ago is that the only appropriate textbook that I new of, Pearlman and Collins's Neurobiology of Disease (Oxford University Press, 1989), was out of print. But even that book was more oriented toward the other direction of information flow, from neuroscience to clinicians. Now a book with the same name aims mainly at the target audience of neuroscientists. It has no competitors, to my knowledge, but could be supplemented by a similar text for psychiatric disorders.
From the Publisher
"I think [the book] is very valuable, and it has benefited from careful editing and good organization. ...Overall, I think the book does achieve the goals that Gilman proposed — he and his colleagues are to be congratulated."
-Guy McKhann, MD, Johns Hopkins University in the NEW ENGLAND JOURNAL OF MEDICINE, May 30, 2007
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Product Details

  • ISBN-13: 9780080466385
  • Publisher: Elsevier Science
  • Publication date: 9/6/2011
  • Sold by: Barnes & Noble
  • Format: eBook
  • Edition number: 1
  • Pages: 1104
  • File size: 37 MB
  • Note: This product may take a few minutes to download.

Table of Contents

Part I. Central Nervous System

Section A. Metabolic Diseases – Hugo W. Moser

Chapter 1: Leukodystrophies
Chapter 2: Lysosomal Disorders of the Nervous System
Chapter 3: The Neurobiology of Peroxisomal Disorders
Chapter 4: Creatine Deficiency Syndromes

Section B. Neurodegenerative Disorders – Gregor Wenning

Chapter 5: Parkinson’s Disease
Chapter 6: Alzheimer Disease
Chapter 7: Multiple System Atrophy
Chapter 8: Olivopontocerebellar Atrophy (OPCA)
Chapter 9: Neurobiology of Progressive Supranuclear Palsy

Section C. Genetic Diseases – Christopher Gomez

Chapter 10: Protein Aggregation Disorders
Chapter 11: RNA-Based Disorders of Muscle and Brain
Chapter 12: Ion Channel Disorders
Chapter 13: Spinocerebellar Ataxia Type 1
Chapter 14: Shared Transcriptional Consequences of Mitochondrial Disease, Ischemic Hypoxia and Chemical Hypoxia

Section D. Neuroimmunological Disorders – Anthony T. Reder

Chapter 15: Paraneoplastic Neurological Disorders
Chapter 16: Systemic Lupus Erythematosus: Descriptive Past and Mechanistic Future
Chapter 17: Progressive Multifocal Leukoencephalopathy
Chapter 18: Multiple Sclerosis
Chapter 19: Immune-Mediated Neuropathies
Chapter 20: Hashimoto Encephalopathy

Section E. Cerebrovascular Diseases – Lewis Morgenstern

Chapter 21: Vascular Cognitive Impairment
Chapter 22: Cardioembolism
Chapter 23: Coagulation Disorders
Chapter 24: Clinical and Neurobiological Aspects of Stroke Recovery
Chapter 25: Non-Atherosclerotic Cerebral Vasculopathies
Chapter 26: Subarachnoid Hemorrhage
Chapter 27: Cerebral Ischemia: Molecular Mechanisms and Protective Therapies
Chapter 28: Intracerebral Hemorrhage and Intraventricular Hemorrhage-Induced Brain Injury

Section F. Paroxysmal Disorders – Timothy A. Pedley

Chapter 29: Idiopathic Epilepsies
Chapter 30: Paroxysmal Dyskinesia
Chapter 31: Neurobiology of Myoclonus
Chapter 32: Channelopathies of the Nervous System
Chapter 33: Migraine
Chapter 34: Temporal Lobe Epilepsy

Section G. Neoplastic Diseases – John Laterra

Chapter 35: CNS Metastases
Robert J. Weil

Chapter 36: Meningioma
Katrin Lamszus, Christian Hagel, and Manfred Westphal

Chapter 37: CNS Lymphoma
Corresponding Author: Dr. Batchelor

Chapter 38: Neurofibromatosis 1
Linda Piersall and David H. Gutmann

Chapter 39: Medulloblastoma and Primitive Neuroectodermal Tumors
Said Elshihabi and James T. Rutka

Chapter 40: Glioma
Anders I. Persson, QiWen Fan, Joanna J. Phillips, and William A. Weiss

Section H. Infectious Diseases – Richard T. Johnson

Chapter 41: Bacterial&Fungal
Chapter 42: Parasitic Infections
Chapter 43: Prion Diseases
Chapter 44: Central Nervous System Viral Infections: Clinical Aspects and Pathogenic Mechanisms

Section I. Motor Neuron Diseases – Eva L. Feldman

Chapter 45: Spinal Muscular Atrophy
Chapter 46: Amyotrophic Lateral Sclerosis-Like Syndromes Associated with Malignancy
Chapter 47: Amyotrophic Lateral Sclerosis (ALS): Idiopathic and Inherited
Chapter 48: Hereditary Spastic Paraplegia and Primary Lateral Sclerosis
Chapter 49: Poliomyelitis
Chapter 50: Spinobulbar Muscular Atrophy (Kennedy’s Disease)

Section J. Malformations and Developmental Disorders – Michael V. Johnston

Chapter 51: Neurobiology of Genetic Mental Retardation
Chapter 52: Cerebral Palsy
Chapter 53: Autism
Chapter 54: Neurobiology of Dyslexia
Chapter 55: Neonatal Brain Injuries
Chapter 56: Spina Bifida
Chapter 57: Circuits to Synapses: The Pathophysiology of Tourette Syndrome
Chapter 58: Attention Deficit Hyperactivity Disorder
Chapter 59: Congenital Hydrocephalus

Section K. Neurologic Manifestations of Medical Diseases – John J. Caronna

Chapter 60: Hematological Disorders
Chapter 61: Renal Disease
Chapter 62: Diabetes and Endocrine Disorders
Chapter 63: Mechanisms and Consequences of CNS Hypoxia
Chapter 64: Gastroenterologic and Hepatic Diseases and Their Effects on CNS
Chapter 65: Sarcoidosis

Section L. Sleep Disorders – Emmanuel Mignot

Chapter 66: REM Sleep Behavior Disorder
Chapter 67: The Neurobiology of Narcolepsy and Hypersomnia
Chapter 68: Restless Legs Syndrome and Periodic Leg Movement
Chapter 69: Obstructive Sleep Apnea
Chapter 70: The Neurobiology of Insomnia

Section M. Substance Abuse and Basic Toxicology – John C. M. Brust

Chapter 71: Organic Chemicals
Chapter 72: Metals
Chapter 73: Drug Addiction

Section N. Imaging the Nervous System – John C. Mazziotta

Chapter 74: Assessment of Neurobiological Diseases with Magnetic Resonance Spectroscopy
Chapter 75: Magnetic Resonance Imaging
Chapter 76: Neurovascular CT Angiography
Chapter 77: PET Imaging in Parkinson's Disease and Other Neurodegenerative Disorders
Chapter 78: Single Photon Emission Computed Tomography (SPECT)
Chapter 79: Functional Magnetic Resonance Imaging (fMRI)

Part II. Peripheral Nervous System

Section O. Peripheral Neuropathies – James Russell

Chapter 80: Diabetic and Metabolic Neuropathies
Chapter 81: Aquired Inflammatory Demyelinating and Axonal Neuropathies
Chapter 82: Toxic and Drug-Induced Neuropathies
Chapter 83: Hereditary Neuropathies
Chapter 84: Neurological Manifestations of Vasculitis
Chapter 85: Neuropathies Associated with Infections

Section P. Myopathies and neuromuscular junction disorders – Charles A. Thornton

Chapter 86: The Muscular Dystrophies
Chapter 87: Myasthenia Gravis and Myasthenic Syndromes
Chapter 88: Myopathies and Neuromuscular Junction Disorders
Chapter 89: Immunobiology of Autoimmune Inflammatory Myopathies

Section Q. Autonomic Disorders – Phillip A. Low

Chapter 90: Central Autonomic Network
Chapter 91: Autonomic Neuropathies
Chapter 92: Thermoregulation and its Disorders
Chapter 93: Control of Blood Pressure-Normal and Abnormal

Section R. Pain – Kenneth L. Casey

Chapter 94: Neoplasm-Induced Pain
Chapter 95: Pain Associated with the Autonomic Nervous System
Chapter 96: Post-Herpetic Neuralgia
Chapter 97: Central Post-Stroke Pain
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