Neurobiology of Huntington's Disease: Applications to Drug Discovery / Edition 1

Neurobiology of Huntington's Disease: Applications to Drug Discovery / Edition 1

by Donald C. Lo, Robert E. Hughes
     
 

ISBN-10: 0849390001

ISBN-13: 9780849390005

Pub. Date: 07/01/2010

Publisher: Taylor & Francis

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result

Overview

In 1993, the genetic mutation responsible for Huntington’s disease (HD) was identified. Considered a milestone in human genomics, this discovery has led to nearly two decades of remarkable progress that has greatly increased our knowledge of HD, and documented an unexpectedly large and diverse range of biochemical and genetic perturbations that seem to result directly from the expression of the mutant huntingtin gene.

Neurobiology of Huntington’s Disease: Applications to Drug Discovery presents a thorough review of the issues surrounding drug discovery and development for the treatment of this paradigmatic neurodegenerative disease. Drawing on the expertise of key researchers in the field, the book discusses the basic neurobiology of Huntington’s disease and how its monogenic nature confers enormous practical advantages for translational research, including the creation of robust experimental tools, models, and assays to facilitate discovery and validation of molecular targets and drug candidates for HD. Written to support future basic research as well as drug development efforts, this volume:

  • Covers the latest research approaches in genetics, genomics, and proteomics, including high-throughput and high-content screening
  • Highlights advances in the discovery and development of new drug therapies for neurodegenerative disorders
  • Examines the practical realities of preclinical testing, clinical testing strategies, and, ultimately, clinical usage

While the development of effective drug treatments for Huntington's disease continues to be tremendously challenging, a highly interactive and cooperative community of researchers and clinical investigators now brings us to the threshold of potential breakthroughs in the quest for therapeutic agents. The impressive array of drug discovery resources outlined in the text holds much promise for treating this devastating disease, providing hope to long-suffering Huntington’s disease patients and their families.

Product Details

ISBN-13:
9780849390005
Publisher:
Taylor & Francis
Publication date:
07/01/2010
Series:
Frontiers in Neuroscience Series
Pages:
338
Product dimensions:
6.40(w) x 9.40(h) x 0.90(d)

Table of Contents

Series Preface xiii

Preface xv

Editors xvii

Contributors xix

Chapter 1 Huntington's Disease: Clinical Features and Routes to Therapy Henry L. Paulson Roger L. Albin 1

Chapter 2 Huntington's Disease Pathogenesis: Mechanisms and Pathways Albert R. La Spada Patrick Weydt Victor V. Pineda 29

Chapter 3 Protein Interactions and Target Discovery in Huntington's Disease John P. Miller Robert E. Hughes 55

Chapter 4 Target Validation for Huntington's Disease Seung P. Kwak James K. T. Wang David S. Howland 85

Chapter 5 High-Throughput and High-Content Screening for Huntington's Disease Therapeutics Hemant Varma Donald C. Lo Brent R. Stockwell 121

Chapter 6 Value of Invertebrate Genetics and Biology to Develop Neuroprotective and Preventive Medicine in Huntington's Disease Christian Neri 147

Chapter 7 Mouse Models for Validating Preclinical Candidates for Huntington's Disease X. William Yang Michelle Gray 165

Chapter 8 Pharmaceutical Development for Huntington's Disease Richard J. Morse Janet M. Leeds Douglas Macdonald Larry Park Leticia Toledo-Sherman Robert Pacifici 197

Chapter 9 RNA- and DNA-Based Therapies for Huntington's Disease Meghan Sass Neil Aronin 225

Chapter 10 Recombinant Intrabodies as Molecular Tools and Potential Therapeutics for Huntington's Disease Ali Khoshnan Amber L. Southwell Charles W. Bugg Jan C. Ko Paul H. Patterson 255

Chapter 11 Biomarkers to Enable the Development of Neuroprotective Therapies for Huntington's Disease Steven M. Hersch H. Diana Rosas 267

Chapter 12 Huntington's Disease: Clinical Experimental Therapeutics E. Ray Dorsey Ira Shoulson 285

Index 299

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