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Doody's Review ServiceReviewer: Michael Joel Schrift, DO, MA (University of Illinois at Chicago College of Medicine)
Description: This is the fourth edition of this absolutely first-rate and comprehensive book covering the progress made in understanding the neurobiological mechanisms involved in psychiatric disorders. Written and edited by the major researchers in psychiatry, this outstanding book remains a significant and important contribution to the field.
Purpose: The purpose is to update "the growing knowledge of all psychiatric syndromes - their etiology, pathophysiology and treatment." The editors state that, "No other book distills the basic science and underpinnings of mental disorders and explains the clinical significance to the scope and breadth of this classic text."
Audience: The intended audience is, according to the editors, "psychiatry residents, psychiatric researchers, and doctoral and post-doctoral fellows in the neurosciences."
Features: This edition is completely revised and divided into nine sections, now with 89 chapters. Part 1 is an overview of basic neuroscience with very informative chapters on brain development, electrophysiology, signal transduction, plasticity, molecular biology, and epigenetics. Part 2 covers new methods and technologies with chapters on such topics as transgenic models, stem cells, optogenetics, drug delivery, brain imaging, and image-guided brain stimulation. Parts 3 through 8, as in the previous edition, review the neurobiological aspects of psychoses, mood disorders, anxiety disorders, substance abuse disorders, dementia, and childhood onset disorders. Part 9 contains very interesting chapters on the DSM-5 and a critique of psychiatric diagnosis, the NIMH Research Domain, personality, aggression, social attachment, sleep, the neurobiology of resilience, and eating disorders. Each chapter ends with relevant and timely citations.
Assessment: This book continues to be an outstanding testament to the effort made towards a fundamental understanding of psychiatric disorders. The fourth edition is an excellent and complete update on the biological basis of psychiatric disorders. Every psychiatrist should read and refer to this book. It covers the basis of modern psychiatry.