Neurobiology of Mental Illness by Eric J. Nestler, Hardcover | Barnes & Noble
Neurobiology of Mental Illness

Neurobiology of Mental Illness

by Eric J. Nestler
     
 

The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic

Overview

The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.
For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, DO, MA (Northwestern University Feinberg School of Medicine)
Description: This is the second edition of a highly acclaimed book covering the current state-of-the-art of the neurobiology of psychiatric disorders. The neuroanatomist and neuropsychiatrist Theodor Meynert stated more than 100 years ago, "The more that psychiatry seeks, and finds, its scientific basis in a deep and finely grained understanding of the anatomical structure [of the brain], the more it elevates itself to the status of a science that deals with causes." This book is a compendium of reviews on the biological underpinnings of psychiatric disorders. Written and edited by the major researchers in psychiatry, this new and significantly improved edition remains an outstanding contribution to the field.
Purpose: The purpose is to update the reader on the enormous advances that have been made in neuroscience as related to psychiatric disorders. The editors state, "The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders." This book chronicles modern psychiatry's first steps toward this goal.
Audience: The intended audience is psychiatrists, psychologists, residents in psychiatry, and mental health workers who want to know what modern psychiatry is about.
Features: The book is divided into nine parts and 80 chapters. Part 1 is an overview of basic neuroscience. Part 2 covers methods of clinical neurobiological research with chapters on such topics as epidemiology, molecular genetics, psychophysiology, neurochemistry, neuroimmunology, cognitive neuroscience, and neuroimaging. Part 3 through part 8 review the neurobiologic aspects of psychoses, mood disorders, anxiety disorders, substance abuse disorders, dementia, and childhood onset disorders. Part 9 contains very interesting chapters on neuropsychiatry, personality, aggression, sexual dysfunction, social attachment, eating disorders, menstrual related mood disorders, circadian rhythms, sleep, and cardio/cerebrovascular disease in relation to depression. Each chapter ends with relevant and timely citations and there is a useful index.
Assessment: This is an excellent and extensively updated edition of this book on the biological basis of psychiatric disorders. Every psychiatrist should read and refer to this book. It covers the basis of modern psychiatry.
From the Publisher
"The second edition of Neurobiology of Mental Illness...stands as a superb contribution to the understanding of neurobiological bases of mental disorders. It is a highly readable, well-organized text. Anyone interested in the neurobiological underpinnings of psychiatric conditions would be well served to have this text on hand, both for casual browsing and for in-depth study." —The Journal of Nervous and Mental Disease

"The chapters are clearly and consistently written and attractively presented. This volume embodies a thoroughgoing materialism." -Cognitive Neuropsychiatry

Praise for the First Edition:

"Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds." —JAMA

". . . well-written, neatly organized, and synthetic . . . a text of this sort is a requisite for any modern psychiatry residency curriculum . . . Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds."—Steven J. Siegel, MD, PhD, in JAMA


"The authors are uniformly first rate...The discipline described here is a far cry from the psychiatry we grew up with. Sigmund Freud, a neurobiologist by training, would have been proud."—J.L. Numberger Jr., in The New England Journal of Medicine

"The editors deserve tremendous credit for compiling a most useful reference text, and I am not aware of a similar textbook that is anywhere as comprehensive, up-to-date, or focused on the basic science of our field. I think this book would be an excellent resource for psychiatric residents, early doctoral students in neurochemistry and the neurosciences, and psychiatric researchers interested in the basic underpinnings of mental disorders."—David L. Dunner in The American Journal of Psychiatry

"...an excellent book, well written and well edited...and packed with information. I found it thought-provoking and intensely educational."—Tim Betts in Brain

"The book provides a well-written, neatly organized, and synthetic middle ground between a more comprehensive text of clinical psychiatry, as provided in Synopsis of Psychiatry...and basic neuroscience texts, such as Principles of Neuroscience..." JAMA

"...the best account to date of the neurobiology of mental disorders. It is an excellent source of reference but many of the chapters provide very good conceptual overviews that well deserve to be read as introductions to the field. A book to dip into for pleasure, as well as one to turn to in order to find out what is known on a particular topic."—Sir Michael Rutter in Trends in Neuroscience

4 Stars! from Doody
Michael J. Schrift
This is an outstanding and comprehensive textbook covering the current state of progress in the neurobiological mechanisms involved in neuropsychiatric disorders. Edited and authored by internationally recognized researchers, this is an exceptionally valuable contribution to this field. The purpose, according to the editors, is to track the evolving progress in the neurobiological basis of psychiatric illness and further the maturation of psychiatry as a modern medical specialty. The have certainly succeeded in their goal. The intended audience is psychiatrists and other mental health workers. It should be mandatory reading for residents in psychiatrist training programs. Part I is an overview of the basic neuroscientific underpinnings of psychiatry. Part 2 is a review of the ""tools that are currently available to study mental illness in humans."" The remaining sections cover such topics as dementia and childhood neuropsychiatric disorders. The sections begin with a critical overview of the diagnostic categories and the subsequent chapters are reviews of animal models, with current theories regarding the biological basis of specific psychopathologies followed by the neurobiological basis for treatment. Each chapter ends with up-to-date and useful references. The book ends with a useful index. This is an extremely valuable textbook on the biological basis of psychiatry. Clinicians and researchers as well as trainees will, without a doubt, benefit from reading and referring to it.
New England Journal of Medicine
This is not a how-to book for diagnosis and treatment, nor should it be regarded as offering an overview of schools of thought in modern psychiatry. It is, rather, a reference book on the neurobiologic underpinnings of our concepts of psychiatric illness. It should find a place on the shelf of practitioners in mental health-related fields, since it will help them interpret the reports they will see in the future on genetic and neuroanatomical abnormalities in their patients.

Product Details

ISBN-13:
9780195149623
Publisher:
Oxford University Press, USA
Publication date:
10/01/2003
Edition description:
Older Edition
Pages:
1272
Product dimensions:
11.25(w) x 8.80(h) x 2.10(d)

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