Neurobiology of Mental Illness

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The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and ...
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Overview


The new edition of this definitive textbook reflects the continuing reintegration of psychiatry into the mainstream of biomedical science. The research tools that are transforming other branches of medicine - epidemiology, genetics, molecular biology, imaging, and medicinal chemistry - are also transforming psychiatry. The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders. The Neurobiology of Mental Illness is written by world-renowned experts in basic neuroscience and the pathophysiology and treatment of psychiatric disorders. It begins with a succint overview of the basic neurosciences followed by and evaluation of the tools that are available for the study of mental disorders in humans. The core of the book is a series of consistently organized sections on the major psychiatric disorders that cover their diagnostic classification, molecular genetics, functional neuroanatomy, neurochemistry and pharmacology, neuroimaging, and principles of pharmacotherapy. Chapters are written in a clear style that is easily accessible to practicing psychiatrists, and yet they are detailed enough to interest researchers and academics.
For this second edition, every section has been thoroughly updated, and 13 new chapters have been added in areas where significant advances have been made, including functional genomics and animal models of illness; epidemiology; cognitive neuroscience; postmortem investigation of human brain; drug discovery methods for psychiatric disorders; the neurobiology of schizophrenia; animal models of anxiety disorders; neuroimaging studies of anxiety disorders; developmental neurobiology and childhood onset of psychiatric disorders; the neurobiology of mental retardation; the interface between neurological and psychiatric disorders; the neurobiology of circadian rhythms; and the neurobiology of sleep disorders. Both as a textbook and a reference work, Neurobiology of Mental Illness represents a uniquely valuable resource for psychiatrists, neuroscientists, and their students or trainees.

The book contains predominantly black-and-white illustrations, with some color illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Michael Joel Schrift, D.O., M.A.(University of Illinois at Chicago College of Medicine)
Description: This is the second edition of a highly acclaimed book covering the current state-of-the-art of the neurobiology of psychiatric disorders. The neuroanatomist and neuropsychiatrist Theodor Meynert stated more than 100 years ago, "The more that psychiatry seeks, and finds, its scientific basis in a deep and finely grained understanding of the anatomical structure [of the brain], the more it elevates itself to the status of a science that deals with causes." This book is a compendium of reviews on the biological underpinnings of psychiatric disorders. Written and edited by the major researchers in psychiatry, this new and significantly improved edition remains an outstanding contribution to the field.
Purpose: The purpose is to update the reader on the enormous advances that have been made in neuroscience as related to psychiatric disorders. The editors state, "The field stands poised to make dramatic advances in defining disease pathogenesis, developing diagnostic methods capable of identifying specific and valid disease entities, discovering novel and more effective treatments, and ultimately preventing psychiatric disorders." This book chronicles modern psychiatry's first steps toward this goal.
Audience: The intended audience is psychiatrists, psychologists, residents in psychiatry, and mental health workers who want to know what modern psychiatry is about.
Features: The book is divided into nine parts and 80 chapters. Part 1 is an overview of basic neuroscience. Part 2 covers methods of clinical neurobiological research with chapters on such topics as epidemiology, molecular genetics, psychophysiology, neurochemistry, neuroimmunology, cognitive neuroscience, and neuroimaging. Part 3 through part 8 review the neurobiologic aspects of psychoses, mood disorders, anxiety disorders, substance abuse disorders, dementia, and childhood onset disorders. Part 9 contains very interesting chapters on neuropsychiatry, personality, aggression, sexual dysfunction, social attachment, eating disorders, menstrual related mood disorders, circadian rhythms, sleep, and cardio/cerebrovascular disease in relation to depression. Each chapter ends with relevant and timely citations and there is a useful index.
Assessment: This is an excellent and extensively updated edition of this book on the biological basis of psychiatric disorders. Every psychiatrist should read and refer to this book. It covers the basis of modern psychiatry.
From the Publisher

"The second edition of Neurobiology of Mental Illness...stands as a superb contribution to the understanding of neurobiological bases of mental disorders. It is a highly readable, well-organized text. Anyone interested in the neurobiological underpinnings of psychiatric conditions would be well served to have this text on hand, both for casual browsing and for in-depth study." --The Journal of Nervous and Mental Disease

"The chapters are clearly and consistently written and attractively presented. This volume embodies a thoroughgoing materialism." -Cognitive Neuropsychiatry

Praise for the First Edition:

"Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds." --JAMA

". . . well-written, neatly organized, and synthetic . . . a text of this sort is a requisite for any modern psychiatry residency curriculum . . . Neurobiology of Mental Illness bridges the gap between the science and art of psychiatric medical practice and allows clinicians and researchers to see into each other's worlds."--Steven J. Siegel, MD, PhD, in JAMA


"The authors are uniformly first rate...The discipline described here is a far cry from the psychiatry we grew up with. Sigmund Freud, a neurobiologist by training, would have been proud."--J.L. Numberger Jr., in The New England Journal of Medicine

"The editors deserve tremendous credit for compiling a most useful reference text, and I am not aware of a similar textbook that is anywhere as comprehensive, up-to-date, or focused on the basic science of our field. I think this book would be an excellent resource for psychiatric residents, early doctoral students in neurochemistry and the neurosciences, and psychiatric researchers interested in the basic underpinnings of mental disorders."--David L. Dunner in The American Journal of Psychiatry

"...an excellent book, well written and well edited...and packed with information. I found it thought-provoking and intensely educational."--Tim Betts in Brain

"The book provides a well-written, neatly organized, and synthetic middle ground between a more comprehensive text of clinical psychiatry, as provided in Synopsis of Psychiatry...and basic neuroscience texts, such as Principles of Neuroscience..." JAMA

"...the best account to date of the neurobiology of mental disorders. It is an excellent source of reference but many of the chapters provide very good conceptual overviews that well deserve to be read as introductions to the field. A book to dip into for pleasure, as well as one to turn to in order to find out what is known on a particular topic."--Sir Michael Rutter in Trends in Neuroscience

Michael J. Schrift
This is an outstanding and comprehensive textbook covering the current state of progress in the neurobiological mechanisms involved in neuropsychiatric disorders. Edited and authored by internationally recognized researchers, this is an exceptionally valuable contribution to this field. The purpose, according to the editors, is to track the evolving progress in the neurobiological basis of psychiatric illness and further the maturation of psychiatry as a modern medical specialty. The have certainly succeeded in their goal. The intended audience is psychiatrists and other mental health workers. It should be mandatory reading for residents in psychiatrist training programs. Part I is an overview of the basic neuroscientific underpinnings of psychiatry. Part 2 is a review of the ""tools that are currently available to study mental illness in humans."" The remaining sections cover such topics as dementia and childhood neuropsychiatric disorders. The sections begin with a critical overview of the diagnostic categories and the subsequent chapters are reviews of animal models, with current theories regarding the biological basis of specific psychopathologies followed by the neurobiological basis for treatment. Each chapter ends with up-to-date and useful references. The book ends with a useful index. This is an extremely valuable textbook on the biological basis of psychiatry. Clinicians and researchers as well as trainees will, without a doubt, benefit from reading and referring to it.
New England Journal of Medicine
This is not a how-to book for diagnosis and treatment, nor should it be regarded as offering an overview of schools of thought in modern psychiatry. It is, rather, a reference book on the neurobiologic underpinnings of our concepts of psychiatric illness. It should find a place on the shelf of practitioners in mental health-related fields, since it will help them interpret the reports they will see in the future on genetic and neuroanatomical abnormalities in their patients.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780195149623
  • Publisher: Oxford University Press, USA
  • Publication date: 10/1/2003
  • Edition description: Older Edition
  • Edition number: 2
  • Pages: 1272
  • Product dimensions: 11.25 (w) x 8.80 (h) x 2.10 (d)

Table of Contents

Contributors
Pt. I Introduction to Basic Neuroscience
Introduction
1 Overview of Brain Development 3
2 Neurochemical Systems in the Central Nervous System 12
3 Using Basic Electrophysiology to Understand the Neurobiology of Mental Illness 29
4 Principles of Signal Transduction 41
5 Mechanisms of Neural Plasticity 66
6 Principles of Molecular Biology 76
7 Functional Genomics and Models of Mental Illness 87
Pt. II Methods of Clinical Neurobiological Research
Introduction
8 Contributions of Epidemiology to the Neurobiology of Mental Illness 103
9 Basic Methods for Clinical Molecular Genetics of Psychiatric Illness 112
10 Methods of Affective Clinical Psychophysiology 127
11 Clinical Neurochemistry 141
12 Clinical Neuroendocrinology 155
13 Neuroimmunology 171
14 Cognitive Neuroscience: Bridging Thinking and Feeling to the Brain, and Its Implications for Psychiatry 180
15 Neuroimaging Methodologies: Utilizing Radiotracers or Nuclear Magnetic Resonance 190
16 Methods of Postmortem Investigation of Human Brain 210
17 Drug Discovery and Development Methods for Mental Illness 221
Pt. III Psychoses
Introduction
18 Diagnostic Classification of the Psychoses: Historical Context and Implications for Neurobiology 237
19 Molecular Genetics of Schizophrenia 247
20 Animal Models of the Psychoses 263
21 Pharmacological Models of Psychoses 287
22 The Neurobiology of Schizophrenia 299
23 Functional Brain Imaging Studies in Schizophrenia 311
24 Psychophysiological and Information Processing Approaches to Schizophrenia 324
25 Principles of the Pharmacotherapy of Schizophrenia 339
Pt. IV Mood Disorders
Introduction
26 Diagnostic Classification of Mood Disorders: Historical Context and Implications for Neurobiology 357
27 Linkage and Association Studies of Bipolar Disorders 369
28 Animal Models of Mood Disorders 380
29 The Cellular Neurobiology of Bipolar Disorder 397
30 The Neurochemistry of Depressive Disorders: Preclinical Studies 421
31 The Neurochemistry of Depressive Disorders: Clinical Studies 440
32 Neuroimaging Studies of Mood Disorders 461
33 Principles of the Pharmacotherapy of Depression 491
34 Abnormalities of Brain Structure and Function in Mood Disorders Based Upon Postmortem Investigations 512
Pt. V Anxiety Disorders
Introduction
35 Diagnostic Classification of Anxiety Disorders: DSM-V and Beyond 525
36 Molecular Genetics of Anxiety 535
37 Animal Models of Anxiety Disorders 546
38 Structural and Functional Plasticity in the Hippocampal Formation: Stress, Adaptation, and Disease 558
39 Functional Neuroanatomy of Anxiety and Fear 584
40 The Neurobiology of Anxiety Disorders 605
41 The Neurobiology and Treatment of Obsessive-Compulsive Disorder 628
42 Neuroimaging Studies of Anxiety Disorders 639
43 Principles of Pharmacotherapy for the Anxiety Disorders 661
Pt. VI Substance Abuse Disorders
Introduction
44 Animal Models of Addiction 683
45 Cellular and Molecular Mechanisms of Drug Addiction 698
46 Genetic Epidemiology of Substance Use Disorders 710
47 Effects of Drugs of Abuse on Brain Development 720
48 Neuroimaging in Substance Abuse Research 740
49 Principles of the Pharmacotherapy of Substance Abuse Disorders 753
Pt. VII Dementia
Introduction
50 Diagnostic Classifications: Relationship to the Neurobiology of Dementia 771
51 The Molecular Biology of Alzheimer's Disease 783
52 Pharmacological and Transgenic Animal Models of Alzheimer's Disease 791
53 Functional Neuroanatomy of Learning and Memory 807
54 Neurochemical Systems Involved in Learning and Memory 813
55 Neuropathological and Neuroimaging Studies of the Hippocampus in Normal Aging and in Alzheimer's Disease 821
56 Abnormalities in Brain Structure on Postmortem Analysis of Dementia 836
57 Functional Brain Imaging Studies in Dementia 849
58 Principles of the Pharmacotherapy of Dementia 863
59 Cognitive Impairment in Demyelinating Disease 873
60 Dementia with Lewy Bodies
61 Dementia in Parkinson's Disease 896
Pt. VIII Psychiatric Disorders of Childhood Onset
Introduction
62 Developmental Neurobiology and the Childhood Onset of Psychiatric Disorders 921
63 Molecular Genetics of Childhood- and Adolescent-Onset Psychiatric Disorders 930
64 Neurobiology of Mental Retardation 944
65 The Neurobiology of Autism and the Pervasive Developmental Disorders 954
66 Tourette's Syndrome and Tic-Related Disorders in Children 968
67 Neurobiology of Attention Deficit Hyperactivity Disorder 979
68 The Neurobiology of Childhood Psychotic Disorders 1000
69 Neurobiology of Early-Onset Mood Disorders 1007
70 Childhood Anxiety Disorders: A Cognitive Neurobiological Perspective 1022
Pt. IX Special Topic Areas
71 Neuropsychiatry: The Border Between Neurology and Psychiatry 1049
72 The Neurobiology of Personality and Personality Disorders 1062
73 The Neurobiology of Aggression 1076
74 Sexual Dysfunction and Pharmacological Treatments: Biological Interactions 1086
75 The Neurobiology of Social Attachment 1101
76 The Neurobiology of Eating Disorders 1112
77 The Neurobiology of Menstrual Cycle-Related Mood Disorders 1129
78 The Neurobiology of Circadian Rhythms 1140
79 The Neurobiology of Sleep in Relation to Mental Illness 1160
80 Depression, Cardiovascular Disease, and Cerebrovascular Disease: Implications for Pathophysiology and Treatment 1180
Index 1193
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