Neurodegenerative Disorders: Mechanisms and Prospects for Therapy

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Dahlem Workshop Reports Life Sciences Research Report 51 Neurodegenerative Disorders Mechanisms and Prospects for Therapy Edited by D.L. Price, H. Thoenen and A.J. Aguayo Neurological disorders, particularly the neurodegenerative diseases involving the central nervous system, are characterized by dysfunction and death of specific populations of nerve cells. Cellular and molecular neurobiological strategies have begun to clarify the mechanisms of neuronal degeneration and have led to the design of new approaches ...
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Overview

Dahlem Workshop Reports Life Sciences Research Report 51 Neurodegenerative Disorders Mechanisms and Prospects for Therapy Edited by D.L. Price, H. Thoenen and A.J. Aguayo Neurological disorders, particularly the neurodegenerative diseases involving the central nervous system, are characterized by dysfunction and death of specific populations of nerve cells. Cellular and molecular neurobiological strategies have begun to clarify the mechanisms of neuronal degeneration and have led to the design of new approaches to prevent cell degeneration, promote cell survival, and restore the functions of diseased nerve cells. This book provides new information concerning these processes. Background papers review exciting new developments concerning: (a) the mechanisms of neuronal degeneration caused by genetic factors, excitotoxins, and calcium; (b) the molecular pathology leading to abnormalities in Alzheimer's disease and the spongiform encephalopathies or prion diseases; (c) the biological substrates of cell differentiation, axon guidance, and target recognition during development, repair, and recovery; and (d) the potential therapeutic efficacies of growth factors and grafted cells in re-establishing circuits essential for the restoration of function. The group discussions and background papers in this Dahlem Workshop Report communicate both the excitement and enthusiasm of the participants facing the scientific challenges that are part of this important area of neurobiological research. This volume will be of special interest to professionals in the fields of molecular/cell biology, genetics, neuroanatomy, neurochemistry, developmental neurobiology, and neuropathology as well asclinicians working in neurology and psychiatry. Goal of this Dahlem Workshop: to understand the molecular and cellular mechanisms of neurological disease and to explore new approaches to treatment.

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Table of Contents

Partial table of contents:

Implications of Nematode Neuronal Cell Death for Human Neurological Disorders (H. Horvitz & M. Chalfie).

The Role of Calcium in Cell Death (B. Siesjö).

Amyloid: Cause or Effect in Alzheimer's Disease (C. Masters & K. Beyreuther).

Are Prion Diseases Useful Models for the Study of Common Neurodegenerative Disorders?

(S. Prusiner).

Cell Differentiation, Axon Guidance, and Target Recognition in Vertebrate Neural Development: A Brief Overview (T. Jessell & J. Dodd).

Neurotrophins: A Group of Structurally Related Proteins Supporting the Survival of Neurons (K. Bailey, et al.).

Neurite Growth Inhibitors in the Adult Mammalian Central Nervous System (M. Schwab, et al.).

Gene Replacement Therapy: Strategies and Progress (D. Cournoyer & C. Caskey).

Targeted Gene Expression in Transgenic Animals (J. Julien).

Intracerebral Implantation of Genetically Modified Cells (F. Gage).

Author Index.

Subject Index.

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