Neurodevelopment and Schizophrenia

by Matcheri S. Keshavan, James L. Kennedy, Robin M. Murray

Overview

Developmental neurobiology has made important strides towards clarifying the pathophysiology of psychiatric disorders over the past decade. Nowhere has the link between basic science and clinical insights become clearer than in the field of schizophrenia research. The contributors to this volume provide a state-of-the-art overview of relevant research, including directions for further investigation. The book will be of interest to researchers in psychiatry and neurobiology, students in psychology, and all mental health practitioners.

Product Details

ISBN-13:	9780521126595
Publisher:	Cambridge University Press
Publication date:	01/14/2010
Pages:	516
Product dimensions:	6.70(w) x 9.60(h) x 1.20(d)

About the Author

Matcheri S. Keshavan, M.D., FRCPC MRCPsych is Professor of Psychiatry at the University of Pittsburgh School of Medicine and Director of the Clinical Core, Center for the Neuroscience of Mental Disorders, and Director of the STEP Clinic at the University of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic.

James L. Kennedy, M.D., FRCPC, is Director of the Neuroscience Research Department, and Head, Section of Neurogenetics, at the Centre for Addiction and Mental Health, and also Professor of Psychiatry and Medical Sciences at the University of Toronto.

Robin M. Murray, DSc, FRCPsych is Professor of Psychiatry and Head of the Department of Psychological Medicine at the Institute of Psychiatry, King's College, University of London, as well as Consultant Psychiatrist at the Maudsley Hospital, London.

Table of Contents

1. Genes and brain development Timothy A. Klempan, Pierandrea Muglia and James L. Kennedy; 2. Brain development in healthy children and adolescents: magnetic resonance imaging studies Jay N. Giedd, Michael A. Rosenthal, A. Blythe Rose, Jonathan D. Blumenthal, Elizabeth Molloy, Richard R. Dopp, Liv S. Clasen, Daniel J. Fridberg and Nitin Gogtay; 3. Cognitive development: fMRI studies Beatriz Luna and John Sweeney; 4. Cognitive development in adolescence: cerebral underpinnings, neural trajectories and the impact of aberrations Stephen J. Wood, Cinzia R. DeLuca, Vicki Anderson and Christos Pantelis; 5. Brain plasticity and long-term function after early cerebral insult: the example of very preterm birth Matthew Allin, Chiara Nosarti, Larry Rifkin and Robin M. Murray; 6. Do degenerative changes operate across diagnostic boundaries? The case for glucocorticoids involvement in major psychiatric disorders Carmine M. Pariante and David Cotter; 7. Velo-cardio-facial syndrome (deletion 22q11.2): a homogeneous neurodevelopmental model for schizophrenia Stephan Eliez and Carl Feinstein; 8. Can structural MRI provide an alternative phenotype for genetic studies of schizophrenia? Colm McDonald and Robin M. Murray; 9. Nutritional factors and schizophrenia Sahebarao P. Mahadik; 10. Schizophrenia, neurodevelopment, and epigenetics Arturas Petronis; 11. Early environmental risk factors for schizophrenia Mary Cannon, Kimberlie Dean and Peter B. Jones; 12. Transcriptomes in schizophrenia: assessing altered gene expression with microarrays David A. Lewis, Karoly Mirnics and Pat Levitt; 13. Is there a role for social factors in a comprehensive development model for schizophrenia? Jane Boydell, Jim Van Os and Robin M. Murray; 14. How does drug abuse interact with familial and developmental factors in the aetiology of schizophrenia? Chih-Ken Chen and Robin M. Murray; 15. Developmental dysregulation of the dopamine system and the pathophysiology of schizophrenia Anthony A. Grace; 16. The development of 'mis-wired' limbic lobe circuitry in schizophrenia and bipolar disorder Francine M. Benes; 17. Development of thalamocortical circuitry and the pathophysiology of schizophrenia Darlene S. Melchitzky and David A. Lewis; 18. X chromosome, estrogen, and brain development, implications for schizophrenia Michael Craig, William Cutter, Ray Norbury and Declan Murphy; 19. Premorbid structural abnormalities in schizophrenia Stephen M. Lawrie; 20. Neurodegenerative models of schizophrenia L. Fredrik Jarskog, John H. Gilmore and Jeffrey A. Lieberman; 21. Does disordered brain development cut across diagnostic boundaries? Christian W. Kreipke, David R. Rosenberg and Matcheri S. Keshavan; 22. Can one identify preschizophrenic children? Eugenia Kravariti, Paola Dazzan, Paul Fearon and Robin M. Murray; 23. High risk studies, brain development and schizophrenia Matcheri S. Keshavan; 24. Developmental models and hypotheses-driven early interventions in schizophrenia Matcheri S. Keshavan and Barbara A. Cornblatt.

Editorial Reviews

"This is an excellent book on the relationship between early developmental brain abnormalities and schizophrenia, integrating the developmental and cognitive neurosciences together with genomics/proteonomics. I hope that this book is a step towards the phenomics (phenotyping and diagnosing specific subtypes) and differential therapeutics of schizophrenia. I highly recommend it."
-Doody's Review ServiceG

"In all, an excellent book that delivers a scientific map of recent neurodevelopmental concepts."
-British Journal of Neuroscience Nursing

"The book is highly recommended as an addition to the libraries of those professionals involved in clinical care or research with individuals with severe psychiatric disability. It is dense, thought provoking, and worth the effort."
-JINS, Bernice A. Marcopulos, PhD, University of Virginia

"The editors of Neurodevelopment and Schizophrenia have tapped the talents of some 56 authorities ... to produce one of the most richly rewarding reading experiences that I have had in some time. Without exception, the contributors to this volume provide fresh, interesting, and valuable material from which all persons with a serious interest in schizophrenia can benefit."
-Psychiatric Services, Frederick J. Frese, PhD

From the Publisher

3 Stars from Doody

Reviewer: Michael Schrift, DO (University of Washington School of Medicine)
Description: This outstanding new book focuses on the view, which is firmly established, that schizophrenia is a neurodevelopmental disorder. Written and edited by internationally recognized researchers in the field, this book is a most welcome contribution in the evolution of ideas in psychiatry.
Purpose: The purpose is to document and explain to researchers and clinicians the progress made since 1997 when the editors wrote Neurodevelopment and Adult Psychopathology (Cambridge University Press, 1997). The editors note that the etiology of schizophrenia has always been a mystery, but with the enormous explosion of knowledge in cognitive neuroscience over the past few years, the origins of this devastating syndrome are becoming more comprehensible. This book is a road map toward uncovering this mystery.
Audience: The intended audience includes schizophrenia researchers, psychiatrists, and psychologists. Anyone interested in brain development and the pathologies that are produced when neural development goes awry would benefit from reading this book.
Features: The book features four parts containing 24 chapters. It includes excellent chapters on genes and behavior, cognitive development, brain plasticity, velo-cardio-facial syndrome as a neurodevelopmental model, epigenetic factors, altered gene expression, limbic and thalamocortical circuitry, neurodegenerative models, at-risk studies, and early intervention. Each chapter is scholarly written with relevant and contemporaneous references. The index is useful.
Assessment: This is an excellent book on the relationship between early developmental brain abnormalities and schizophrenia, integrating the developmental and cognitive neurosciences together with genomics/proteonomics. I hope that this book is a step towards the phenomics (phenotyping and diagnosing specific subtypes) and differential therapeutics of schizophrenia. I highly recommend it.

Doody's Review Service