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Doody's Review ServiceReviewer: Daniel B. Hier, MD (University of Illinois at Chicago College of Medicine)
Description: This is one of a continuing series of books in the Methods of Molecular Biology series that provides detailed information on molecular methods. This volume details methods used to study neurogenetic disorders.
Purpose: This is a "cookbook" designed to assist investigators and laboratory scientists who use these methods routinely in their research and diagnostic work. It is specialized to laboratory methods applicable to diagnosis of neurogenetic disorders.
Audience: This book will be of interest to neurogeneticists, neuroscientists, and molecular biologists who study neurogenetic disorders by laboratory methods.
Features: This book provides detailed laboratory methods in its of 32 chapters. Each chapter provides sufficient detail to allow the duplication of the laboratory method. The emphasis is on neurogenetic diseases and the methods are all molecular biological including PCR, DNA sequencing, Western Blot, and Southern Blot. Diseases covered include Huntington's disease, Charcot-Marie-Tooth, Rett's Syndrome, Leber's Optic Atrophy, spinocerebellar ataxias, Parkinson's disease, and neurological mitochondrial diseases.
Assessment: This is a unique and highly useful book that details laboratory methods in more detail than any comparable book. Laboratory scientists and investigators who wish to use neurogenetic laboratory methods to study these disorders will find great value in this compendium of methodologies.