The Neuroimmunological Basis of Behavior and Mental Disorders / Edition 1

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The fields of neuroscience, neuroimmunology, and psychiatry have seen remarkable growth over the past decade. For many years, it was believed that viruses, bacteria and other pathogens could precipitate psychiatric and neurological abnormalities. Recent developments in the field of neuroimmunology have provided insights into the possible relationships between immune function and behavioral disorders.

Specifically, a physiological feedback loop between the brain and immune systems, notably involving cytokines, have been identified, thus permitting an analysis of how pathogens may come to potently alter brain function. Such changes may affect adaptive and abnormal behaviors.

This book examines the nature of these relationships. Key topics include: basic mechanisms of neural-immune interactions; the effects of immunity on normal brain neurochemistry and behavioral processes; and how immune activity may contribute to clinical disorders such as schizophrenia, depression, aggression, pain and stress.

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Product Details

  • ISBN-13: 9781441946577
  • Publisher: Springer US
  • Publication date: 11/4/2010
  • Edition description: Softcover reprint of hardcover 1st ed. 2009
  • Edition number: 1
  • Pages: 438
  • Product dimensions: 0.92 (w) x 9.21 (h) x 6.14 (d)

Meet the Author

Allan Siegel, Ph.D., was awarded his doctorate from the State University of New York at Buffalo in 1966 and was trained in the fields of Neurophysiology, Neuroanatomy and Behavioral Neuroscience at Yale University School of Medicine. He is Professor of Neurology and Neuroscience and Psychiatry at New Jersey Medical School's University of Medicine and Dentistry in Newark, New Jersey. His research focuses on the anatomical substrates and neurochemical mechanisms, including the functions of cytokines, governing aggression, and rage behavior.

Steven S. Zalcman, Ph.D. was awarded his doctorate from Carleton University, Ottawa, Canada in 1990, and was a postdoctoral fellow at the Manitoba Institute of Cell Biology, University of Manitoba Medical School. He received training in Behavioral Neuroscience, Neurochemistry, Anatomy, and Immunology. He held a faculty position in the Department of Psychology, Concordia University, Montreal, Canada, and is presently Associate Professor of Psychiatry at New Jersey Medical School's University of Medicine and Dentistry in Newark, New Jersey. His research focuses on neurochemical, neuropharmacological, and behavioral consequences of immune activation and cytokine treatment.

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Table of Contents

Neuroimmune Interactions.- Cytokines and the Blood–Brain Barrier.- Neurochemical and Endocrine Responses to Immune Activation: the Role of Cytokines.- Neural Pathways Mediating Behavioral Changes Associated with Immunological Challenge.- Molecular Basis of Cytokine Function.- Interferon-?, Molecular Signaling Pathways and Behavior.- Exercise and Stress Resistance: Neural-Immune Mechanisms.- Neuroimmunological Basis of Behavior.- Alteration of Neurodevelopment and behavior by Maternal Immune Activation.- Interleukin-2 and Septohippocampal Neurons: Neurodevelopment and Autoimmunity.- Cytokine-Induced Sickness Behavior and Depression.- Effect of Systemic Challenge with Bacterial Toxins on Behaviors Relevant to Mood, Anxiety and Cognition.- Cytokines, Immunity and Sleep.- Cytokines and Aggressive Behavior.- Neurochemical and Behavioral Changes Induced by Interleukin-2 and Soluble Interleukin-2 Receptors.- Neuroimmunological Basis of Mental Disorders.- Immunity and Depression: A Clinical Perspective.- Cytokines, Immunity and Schizophrenia with Emphasis on Underlying Neurochemical Mechanisms.- Immunobiological and Neural Substrates of Cancer-Related Neurocognitive Deficits.- Autoimmunity and Brain Dysfunction.- Viruses and Psychiatric Disorders.- Microglial Cells and Inflammatory Cytokines in the Aged Brain.

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