Neurological and Psychiatric Disorders / Edition 1

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A comprehensive, systematic, and advanced review of the scientific, preclinical, and clinical aspects of several major mental illnesses. The illnesses covered range from neurological disorders including Alzheimer's disease, Huntington's disease, and Parkinson's disease, to psychiatric disorders including schizophrenia, autism spectrum disorders, Tourette's syndrome and tic disorders, obsessive-compulsive disorder, unipolar depression, bipolar disorder, and attention deficit hyperactivity disorder. For each disorder, the authors uniformly discuss its incidence and prevalence, etiology, molecular targets and mechanisms of action, brain structures and pathways, animal models, signs and symptoms, genetics, treatments, and related medical terminology.

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Editorial Reviews

Doody's Review Service
Reviewer: Adam Kaplin, MD, PhD (Johns Hopkins University School of Medicine)
Description: When I was in medical school a respected senior member of the neurology department was fond of pointing out to the residents and medical students that "the most common setting for functional disorders is in the context of organic illnesses." Modern research has confirmed this observation and extended it by investigating the organic etiology of functional (i.e. psychiatric) disorders. In this book, the editors have assembled an impressive group of authors to flesh out the syllabus of a graduate level course on the neuroscientific basis of neurologic and psychiatric illnesses that Dr. Schetz still teaches to this day.
Purpose: Although the specific reasons are not made explicit for producing a book that focuses on the chosen three neurologic and seven psychiatric disorders (for example, multiple sclerosis is omitted despite being commonly regarded as having one of the highest comorbid rate of depression), one of the author's goals is to facilitate MD, PhD and PharmD candidates' mastery of their qualifying exams.
Audience: To be sure, there is now a growing awareness of the need for neurologists and psychiatrists to understand one another's clinical discipline as it impacts their patients. There is also a need for these sister disciplines to stay well informed about the rapidly growing role of neuroscience in explaining and rationalizing their understanding of the way insults to the nervous system result in neurological and psychiatric disorders. But the editors' exuberant suggestion that their book will allow their readers to "effectively and safely practice their future health care professions" is patently misleading, and care should be taken by readers to understand the book's limitations.
Features: The two chapters devoted to mood disorders illustrate the limitations of the book's general organization. The chapter on unipolar depression is written by two PhDs who, in 15 pages, provide a remarkably informative overview of the contemporary understanding of the neuroscientific basis of major depression. Their discussion of the clinical aspects of depression is often misleading (e.g. citing "concerns about the safety and efficacy" of ECT treatment) and occasionally wrong (e.g. defining atypical depression as "depression with a greater expression of anxiety or agitation"). By contrast, the chapter on bipolar disorder written by a premier group of MDs, provides an excellent summary of the clinical aspects of this mood disorder while devoting two of 23 pages to a limited discussion of the current neuroscientific research in this area. The editors would have enhanced their book considerably by requesting their PhDs to focus on neuroscience and the MDs on clinical aspects of these disorders.
Assessment: Whereas there is much information that is timely and succinct in this survey of these 10 disorders, the book suffers the most from its over-reaching goal to "promote a systematic, comprehensive, and advanced understanding of each disorder from molecules to human behavior." Ultimately, this occasionally stretches the authors beyond the limits of their expertise and too often makes their discussions so dense as to be impenetrable for many in their target audience.

2 Stars from Doody
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Product Details

  • ISBN-13: 9781588293695
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 1/28/2005
  • Series: Current Clinical Neurology Series
  • Edition description: 2005
  • Edition number: 1
  • Pages: 264
  • Product dimensions: 6.38 (w) x 9.42 (h) x 0.94 (d)

Table of Contents

1 Neural principles of neurological and psychiatric disorders 3
2 Pharmacotherapeutic principles of neurological and psychiatric disorders 29
3 Alzheimer's disease 51
4 Huntington's disease 63
5 Parkinson's disease 87
6 Schizophrenia 111
7 Autism spectrum disorders 131
8 Tourette's syndrome and tic disorders : from molecules and cells to symptoms and management 151
9 Obsessive-compulsive disorder 171
10 Unipolar depression 189
11 Bipolar disorder 205
12 Attention deficit hyperactivity disorder 229
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