Neuropathology and Genetics of Dementia

by Markus Tolnay (Editor), Alphonse Probst (Editor)

Overview

Proceedings from the XVIIIth International Winter Meeting of the Swiss Society of Neuropathology, held in March 2000 in St. Moritz, Switzerland, bringing together neuropathologists, clinicians and neuroscientists interested in disease mechanisms. Nineteen contributions by over 60 international specialists explore a variety of dementing disorders. A sampling of topics: the molecular parameters of tau pathology; argyrophilic grain disease; the spectrum of vascular disease in dementia; ubiquitin and the molecular pathology of neurodegenerative diseases; and pathological mechanisms in polyglutamine expansion diseases.

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Product Details

ISBN-13:	9780306465581
Publisher:	Springer US
Publication date:	05/31/2001
Series:	Advances in Experimental Medicine and Biology , #487
Edition description:	2001
Pages:	255
Product dimensions:	7.01(w) x 10.00(h) x 0.02(d)

Table of Contents

Can the Physician Predict the Neuropathologist?.- The Molecular Parameters Of Tau Pathology.- Tau as a killer and a witness.- Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17.- Argyrophilic Grain Disease.- A frequent dementing disorder in aged patients.- Tau Pathology in Neurons and Glial Cells of Aged Baboons.- Human Tau Transgenic Mice.- Towards an animal model for neuro-and glialfibrillary lesion formation.- Regulation of Alzheimer 13-Amyloid Precursor Trafficking and Metabolism.- Role of Type 10 1713-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer’s Disease.- The Spectrum Of Vascular Disease In Dementia.- From ischemia to amyloid angiopathy.- Transgenic Mouse Models of Cerebral Amyloid Angiopathy.- Alpha-Synuclein.- Axonal transport, ligand interaction and neurodegeneration.- Dementia with Lewy Bodies.- Mouse Models of—-Synucleinopathy and Lewy Pathology.-—-synuclein expression in transgenic mice.- Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases.- Perisomatic Granules of Hippocampal CA1 Neurons in Alzheimer’s Disease, Pre-Alzheimer Stage and Pick’s Disease: an Overlooked Pathological Entity.- Ubiquitin and the Molecular Pathology of Neurodegenerative Diseasespathological Mechanisms in Polyglutamine Expansion Diseases.- Dementia in the Neuronal Ceroid-Lipofuscinoses.- Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis.- Mihondrial Dysfunction in Neurodegenerative Disorders and Ageing.