Neuropathology and Genetics of Dementia / Edition 1

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This volume is the proceedings from the Swiss Society for Neuropathology XVIIIth International Winter Meeting on Neuropathology and Genetics of Dementia, held March 23-26, 2000, in St. Moritz, Switzerland.
For more than 35 years the Swiss Society of Neuropathology has organised its traditional International Winter Meeting, whose main aim is to bring together neuropathologists and clinicians as well as neuroscientists interested in disease mechanisms. The topic of the 2000 Meeting was Neuropathology and Genetics of Dementia. A programme of invited plenary lectures of high educational value as well as platform and poster presentations given by many participants covered the broad spectrum of dementing disorders. Encouraged by the high standard of the meeting, and probably also influenced by the advent of a new Millennium, it was decided to publish the Proceedings of the 2000 Meeting in the present book.

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Table of Contents

Can the physician predict the neuropathologist? M.N. Rossor. The Molecular Parameters of Tau Pathology, Tau as a killer and a witness; A. Delacourte . Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17; M.G. Spillantini, M. Goedert . Argyrophilic Grain Disease, a Frequent Dementing Disorder in Aged Patients; M. Tolnay, et al. Tau Pathology in Neurons and Glial Cells of Aged Baboons; C. Schultz, et al. Human Tau Transgenic Mice, Towards an animal model for neuro- and glialfibrillary lesion formation; E. Götz, et al. Regulation of Alzheimer beta-Amyloid Precursor Trafficking and Metabolism; S. Gandy, S. Petanceska . Role of Type 10 17beta-Hydroxysteroid Dehydrogenase In the Pathogenesis of Alzheimer's Disease; Song-Yu Yang, Xue-Ying He. The Spectrum of Vascular Disease in Dementia, From ischemia to amyloid angiopathy; R.O. Weller, S.D. Preston. Transgenic Mouse Models of Cerebral Amyloid Angiopathy; M.C. Herzig, et al. Alpha-Synuclein, Axonal transport, ligand interaction and neurodegeneration; P. Henning Jensen, Wei Ping Gai . Dementia with Lewy Bodies; P. Ince. Mouse Models of alpha-Synucleinopathy and Lewy Pathology, alpha-synuclein expression in transgenic mice; S. Barbieri, et al. Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases; J. Lowe, et al. Perisomatic Granules Of Hippocampal CA1 Neurons in Alzheimer's disease, pre-Alzheimer Stage and Pick's Disease: An Overlooked Pathological Entity; A. Probst, et al. Pathological Mechanisms in Polyglutamine Expansion Diseases; D. Devys, et al. Dementia in the Neuronal Ceroid-Lipofuscinoses; H.H. Goebel, A. Kohlschütter. Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis; J.B. Lampe, et al. MihondrialDysfunction in Neurodegenerative Disorders and Ageing; C. Turner, A.H.V. Schapira. Index.

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