Neuropathology and Genetics of Dementia

Overview

This volume is the proceedings from the Swiss Society for Neuropathology XVIIIth International Winter Meeting on Neuropathology and Genetics of Dementia, held March 23-26, 2000, in St. Moritz, Switzerland.
For more than 35 years the Swiss Society of Neuropathology has organised its traditional International Winter Meeting, whose main aim is to bring together neuropathologists and clinicians as well as neuroscientists interested in disease mechanisms. The topic of the 2000 ...

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Overview

This volume is the proceedings from the Swiss Society for Neuropathology XVIIIth International Winter Meeting on Neuropathology and Genetics of Dementia, held March 23-26, 2000, in St. Moritz, Switzerland.
For more than 35 years the Swiss Society of Neuropathology has organised its traditional International Winter Meeting, whose main aim is to bring together neuropathologists and clinicians as well as neuroscientists interested in disease mechanisms. The topic of the 2000 Meeting was Neuropathology and Genetics of Dementia. A programme of invited plenary lectures of high educational value as well as platform and poster presentations given by many participants covered the broad spectrum of dementing disorders. Encouraged by the high standard of the meeting, and probably also influenced by the advent of a new Millennium, it was decided to publish the Proceedings of the 2000 Meeting in the present book.

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Product Details

  • ISBN-13: 9781461354611
  • Publisher: Springer US
  • Publication date: 12/31/2012
  • Series: Advances in Experimental Medicine and Biology Series , #487
  • Edition description: Softcover reprint of the original 1st ed. 2001
  • Edition number: 1
  • Pages: 255
  • Product dimensions: 6.69 (w) x 9.61 (h) x 0.57 (d)

Table of Contents

Can the Physician Predict the Neuropathologist? 1
The Molecular Parameters of Tau Pathology: Tau as a killer and a witness 5
Tau Gene Mutations and Tau Pathology in Frontotemporal Dementia and Parkinsonism Linked to Chromosome 17 21
Argyrophilic Grain Disease: A frequent dementing disorder in aged patients 39
Tau Pathology in Neurons and Glial Cells of Aged Baboons 59
Human Tau Transgenic Mice: Towards an animal model for neuro- and glialfibrillary lesion formation 71
Regulation of Alzheimer [beta]-Amyloid Precursor Trafficking and Metabolism 85
Role of Type 10 17[beta]-Hydroxysteroid Dehydrogenase in the Pathogenesis of Alzheimer's Disease 101
The Spectrum of Vascular Disease in Dementia: From ischemia to amyloid angiopathy 111
Transgenic Mouse Models of Cerebral Amyloid Angiopathy 123
Alpha-Synuclein: Axonal transport, ligand interaction and neurodegeneration 129
Dementia With Lewy Bodies 135
Mouse Models of [alpha]-Synucleinopathy and Lewy Pathology: [alpha]-synuclein expression in transgenic mice 147
Ubiquitin and the Molecular Pathology of Neurodegenerative Diseases 169
Perisomatic Granules of Hippocampal Ca1 Neurons in Alzheimer's Disease, Pre-Alzheimer Stage and Picks Disease: An Overlooked Pathological Entity 187
Pathological Mechanisms in Polyglutamine Expansion Diseases 199
Dementia in the Neuronal Ceroid-Lipofuscinoses 211
Neurodegeneration-Associated Proteins and Inflammation in Sporadic Inclusion-Body Myositis 219
Mitochondrial Dysfunction in Neurodegenerative Disorders and Ageing 229
Index 253
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