Neuropathology of Aging and Alzheimer's Disease

by Rudy J. Castellani

Overview

Neuropathology of Aging and Alzheimer’s Disease takes a foundational approach to the topic by offering basic scientific information and the latest advancements in the field. The focus of this reference is on neuropathology and recent advances in tissue characterization in aging, and in Alzheimer’s Disease. Neuropathology has direct relevance to therapeutic constructs and allows for an in-depth understanding of disease pathogenesis. It is a synthesis of the salient issues with respect to pathology, pathogenesis, diagnosis, disease, normal aging, biomarker relevance, and prospects for therapeutic intervention.

Product Details

ISBN-13:	9780323996518
Publisher:	Elsevier Science
Publication date:	05/21/2025
Pages:	350
Product dimensions:	7.50(w) x 9.25(h) x 0.00(d)

About the Author

Dr. Rudy Castellani is a professor in the Division of Neuropathology at the Northwestern University Feinberg School of Medicine, the Program Director for the Neuropathology Fellowship Training Program, and the Neuropathology Core Director for the Northwestern University Alzheimer’s Disease Research Center at the Mesulam Center for Cognitive Neurology. He is the recipient of the 2010 Alzheimer medal from the Journal of Alzheimer’s disease. He was formerly professor and vice chair of research, at West Virginia University and the Rockefeller Neuroscience institute, and a former tenured professor and director of neuropathology at University of Maryland, Baltimore. Dr. Castellani has authored or co-authored over 330 research articles, reviews, and chapters, with a focus on neurodegenerative diseases and neurotrauma, and has been quoted in the New York Times on issues related to Alzheimer’s disease treatment.

Table of Contents

Part I: Alzheimer and his contemporaries
1. Alzheimer’s disease: a fortuitous beginning
2. Alzheimer’s first case
3. Alzheimer’s second case and the naming of Alzheimer’s disease
4. Some early observations of Alzheimer’s contemporaries
5. Early studies on senile dementia and aging
6. The human element
References 000
Part II: The dark ages
7. The 1920s and 1930s
8. The 1940s to the 1960s
Part III: Beyond plaques and tangles: lewy bodies, vascular disease, and the rise of the acronyms
9. Lewy bodies
10. The role of vascular disease in Alzheimer’s disease neuropathology Atherosclerosis
11. The rise of the acronym References
12. Aging-related neuronal tau
13. Aging and disease-related astrocytic tau
14. TDP-43 in aging and Alzheimer’s disease
15. Argyrophilic grain disease
Part IV: Alzheimer’s disease, dementia pugilistica, and the influence of neuropathology
16. Introduction to the traumatic brain injury—neurodegenerative disease dichotomy
17. Punch drunk syndrome: the first 30 years
18. Clinicopathological analysis from the 1950s and 1960s
19. 1970 to 2000: transitioning to an immunohistochemistry—only diagnosis
20. The modern chronic traumatic encephalopathy era
21. Postmortem of punch drunk boxers and chronic traumatic encephalopathy
Part V: Familial alzheimer’s disease, down syndrome, and the amyloid cascade hypothesis
22. Familial Alzheimer’s disease and Down syndrome
23. The amyloid cascade hypothesis
Part VI: Practical considerations in the diagnosis of alzheimer’s disease and aging
24. Application of consensus criteria
25. The diagnostic process

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From the Publisher

A complete resource on the pathology, pathogenesis, and pathophysiology of Alzheimer's Disease, providing clinical aspects for a better understanding of the disease