The Neuropathology of Dementia / Edition 1

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Completely rewritten and updated, this new edition is almost twice the size of its predecessor. Illustrated in colour throughout, and with contributions from the world's leading authorities, it is the definitive reference on the neuropathology of dementia. It gives practical guidance to pathologists, describes the contribution of neuroimaging to diagnosis, and surveys the clinical features of dementia.

The book contains black-and-white illustrations.

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Editorial Reviews

Robert Wollman
This book comprehensively covers the clinical and anatomic features of dementia according to the current generally accepted classifications. The editors' stated purpose is to assist the pathologist in determining the cause of dementia from postmortem examination, and this goal is well met by a clearly written text. Although this book is targeted at pathologists, it will be valuable also to neurologists, geriatricians, and psychiatrists who are faced with the task of determining the cause of clinical dementia. Most of the contributors are actively engaged in research in their respective fields. The book is adequately illustrated, although additional color plates would have enhanced the quality of some chapters. As with most textbooks, the most recent references are three years behind the publication date, but almost all important references through 1994 appear in the various chapters. This book more comprehensively deals with both the clinical and anatomic features of dementia that are only superficially treated in the standard neuropathology textbooks. It also deals more carefully with the problems of overlapping syndromes and anatomic findings that frequently plague clinicians and pathologists who see patients with dementia. The belongs in every medical library.
A comprehensive diagnostic reference to the diseases that cause dementia. For 16 individual conditions or groups of them, provides details about the steps needed to make a diagnosis and for differential diagnosis, the current clinical understanding of the condition, its etiology, and pathogenesis. Also discusses more general practical issues involved in diagnosis and tissue studies, including anatomical landmarks, safety aspects, morphometry, and tissue sources. Among the conditions considered are Alzheimer's disease, Parkinson's disease, familial cerebral amyloid angiopathies, head injury, infectious diseases, and schizophrenia. Addressed to neuropathologists, histopathologists, and other clinicians in the neurology and dementia fields. Annotation c. by Book News, Inc., Portland, Or.
From the Publisher
"...this is an excellent book and can be recommended particularly for psychiatry, neurology, and pathology residents, as well as practicing clinicians who frequently see dementia patients in their practices." Clinical Gerontologist

"The writing remains excellent, and the illustrations are now in color." Annals of Neurology, Barbara S. Crain, MD,PhD, Baltimore Maryland

"This authoritative and comprehensive book is one of those 'must have' books and it will be invaluable for practising neuropathologists, as well as gerontologists, neurobiologists and psychiatrists working in the field of dementia. I must admit that I am delighted to have a copy of this book and have used it with more enthusiasm than I have ever thought possible." The Bulletin of the Royal College of Pathologists, Dr. Malee Fernando, Specialist Registrar in Neuropathology, Royal Hallamshire Hospital, Sheffield

"...a must for neuropathologists with an interest in dementia." ACNR, IAJ Larner, M Doran, Cognitive Function Clinic, WCNN, Liverpool

"There are many books on dementia, so an understandable response to news about yet another one is 'What's so special about this one?' The answer in this case is 'It has great perspective and is a joy to read.'" American Neurological Association, Barbara J. Crain

"This is a well-written reference textbook and is most appropriate for physicians and trainees in pathology, clinical neuroscience, and psychiatry with an interest in dementia. Neuroscientists engaged in neurodegenerative research will find it particularly useful as a one-stop resource of current literature."
Ravi Raghavan, Journal of Neurosurgery

Doody's Review Service
Reviewer: Kathy L Newell, MD (University of Kansas Medical Center)
Description: This book is devoted to the current neuropathological knowledge of dementia, including common as well as rare or less well known forms of dementia. The first several chapters introduce useful clinical, anatomical, diagnostic, molecular, and safety-oriented information as background for the disease-specific chapters that follow. The first edition was published in 1997.
Purpose: The purpose is to provide a practical guide to the neuropathological diagnosis of dementia and to extend the original aim by summarizing current research and neurobiological findings in a comprehensive fashion. Because the field of dementia research is experiencing fast-paced growth, these are valuable objectives that have been met through the superb contributions of the editors and the authors they have assembled.
Audience: The intended audience includes pathologists, particularly neuropathologists, who diagnose dementia, as well as clinicians, particularly neurologists and psychiatrists, who treat dementia patients. Graduate students and neurobiologists who study these diseases will also benefit from the comprehensive coverage shared by 45 highly qualified international authors, many of them recognized experts on the topics they present.
Features: The book is presented in 24 chapters that cover clinical features, neuroanatomical review, molecular techniques, morphometric methods, safety issues, neuroimaging approaches, neuropathological criteria, and other background information related to dementia, all major categories of dementia, and less usual or rare types of dementia. A welcome addition to the second edition is a chapter that reviews the burgeoning area of transgenic mouse models of human neurodegenerative disease. The well written section devoted to vascular dementia includes a useful checklist to help apply the guidelines provided in the chapter. The updated information on prion diseases is excellent. The addition of high quality color photographs throughout the book helps clarify key features. The appendix of dementia brain bank addresses is a handy guide, although probably incomplete.
Assessment: The second edition is an important contribution to the neuropathology and dementia literature, greatly extending and updating the information provided in the first edition. Other current books that cover dementias, including Greenfield's Neuropathology, 7th edition, Graham and Lantos (Hodder Arnold, 2002), and Neuropathology: A Reference Text of CNS Pathology, 2nd edition, Ellison et al. (Elsevier, 2004), are not solely devoted to the topic of dementia and do not provide the in-depth coverage or supplemental information presented here. Neuropathology of Dementing Disorders, Markesbery (Hodder Arnold, 1998), needs updating.

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780521433112
  • Publisher: Cambridge University Press
  • Publication date: 4/1/1997
  • Edition description: Older Edition
  • Edition number: 1
  • Pages: 440
  • Product dimensions: 7.44 (w) x 9.69 (h) x 1.06 (d)

Meet the Author

D.O.B. 5/10/41
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Table of Contents

1 Definition, clinical features and neuroanatomical basis of dementia 1
2 Important anatomical landmarks in the brain in dementia 34
3 Practical approach to pathological diagnosis 48
4 Morphometric methods and dementia 75
5 Safety precautions in laboratories involved with dementia diagnosis and research 82
6 Molecular diagnosis of dementia 91
7 Neuropathology of the ageing brain 113
8 Neuroimaging Alzheimer's disease 128
9 Alzheimer's disease 161
10 Down's syndrome and Alzheimer's disease 207
11 Sporadic tauopathies : Pick's disease, corticobasal degeneration, progressive supranuclear palsy and argyrophilic grain disease 227
12 Hereditary tauopathies and idiopathic frontotemporal dementias 257
13 Vascular dementias 289
14 Familial and sporadic cerebral amyloid angiopathies associated with dementia and the BRI dementias 330
15 Parkinson's disease, dementia with Lewy bodies, multiple system atrophy and the spectrum of diseases with [alpha]-synuclein inclusions 353
16 Huntington's disease 376
17 Human prion diseases 402
18 Alcoholism and dementia 427
19 Hydrocephalus and dementia 442
20 Head injury and dementia 457
21 Infectious (and inflammatory) diseases causing dementia 472
22 Schizophrenia and its dementia 497
23 Other diseases that cause dementia 509
24 Transgenic mouse models of neurodegenerative disease 533
App Dementia brain banks 558
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