The Neuropathology of Schizophrenia: Progress and Interpretation / Edition 1

The Neuropathology of Schizophrenia: Progress and Interpretation / Edition 1

by Paul J. Harrison
     
 

ISBN-10: 0192629077

ISBN-13: 9780192629074

Pub. Date: 10/28/2000

Publisher: Oxford University Press, USA

This book provides a much needed, balanced, comprehensive and up-to-da te overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature tho ught to be

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Overview

This book provides a much needed, balanced, comprehensive and up-to-da te overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature tho ught to be central to understanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these f indings, such as the neurodevelopmental hypothesis. Finally, there are chapters considering the conceptual and methodological problems affec ting the subject. This is a timely and unique book on this classic and controversial issue, with contributions from many of the leading inte rnational experts in the field.

Product Details

ISBN-13:
9780192629074
Publisher:
Oxford University Press, USA
Publication date:
10/28/2000
Series:
Oxford Medical Publications Series
Edition description:
New Edition
Pages:
392
Product dimensions:
6.40(w) x 9.30(h) x 1.00(d)

Table of Contents

List of contributorsxi
Introduction1
1Structural Imaging Findings and Macroscopic Pathology5
In vivo brain imaging in schizophrenia7
Brain morphology in schizophrenia8
Global versus regional changes17
Structural abnormalities as part of a neural network35
Timing and progression of structural abnormalities36
Diagnostic specificity of the findings38
Conclusions and future directions39
2Hippocampal Pathology57
Neuroanatomy of the normal hippocampal formation58
Gross morphometry of the hippocampal formation in schizophrenia61
Hippocampal cytoarchitecture and neuronal morphometry in schizophrenia62
Cognitive impairment, dementia, and investigations of neurodegeneration in schizophrenia69
Regional specificity of hippocampal neuropathological findings71
Concluding remarks73
3Cortical Pathology: a New Generation of Quantitative Microscopic Studies81
Stereomorphometric studies82
The cortical GABA system86
The cortical glutamate system88
The cortical dopamine system91
Cortical pathology and the neurodevelopmental hypothesis94
Conclusions95
4Synaptic Pathology105
Assessment of synapses105
Models of synaptic abnormalities in schizophrenia114
Studies of synapses in schizophrenia115
Discussion and conclusions124
5Gliosis and its Implications for the Disease Process137
Glia and gliosis137
Gliosis in schizophrenia140
The meaning of an absence of gliosis143
Conclusions145
6Cerebral Asymmetry151
Structural cerebral asymmetries152
Cerebral asymmetry in schizophrenia155
Conclusions162
7Functional Imaging and Neural Circuitry in Schizophrenia173
Applied neuroimaging and the neuropathology of schizophrenia173
Functional imaging techniques175
Functional imaging and neurocircuitry177
Corticothalamocerebellar circuitry and cognitive dysmetria in schizophrenia182
Summary and conclusion184
8Neuropathology and the Neurodevelopmental Model189
Evidence supporting a neurodevelopmental origin of schizophrenia190
Evidence against schizophrenia as a neurodegenerative disorder193
Neuropathological findings and the neurodevelopmental model195
Limitations of the neurodevelopmental model202
9Cortical Development and Schizophrenia213
Molecular basis for the organisation of the forebrain215
Pattern formation and its functional consequences223
Fate determination227
Concluding remarks229
10The Organization of Cortical Circuitry235
A model system for circuitry analysis: the primate dorsolateral prefrontal cortex236
Cortical neuron types237
Laminar arrangement of neurons239
Organization of efferent projections241
Organization and termination of afferent projections242
Vulnerable prefrontal cortex circuitry in schizophrenia245
11Perspectives from other Diseases and Lesions257
Neuropathology and diagnostic issues257
Diseases sharing non-specific pathological features with schizophrenia258
Disorders in which schizophrenia-like symptoms may occur262
Normal determinants of neuronal parmeters and the effects of experimental lesions265
Suggestions for future studies268
12Animal Models of Schizophrenia277
Modeling schizophrenia in animals: some general considerations278
Neurodevelopmental animal models of schizophrenia280
Future approaches to modeling schizophrenia in animals285
13A Sceptical View of the Neuropathology of Schizophrenia291
Overall brain dimensions292
Lateral ventricular enlargement298
Regional cerebral volumes304
Temporal lobe limbic structures310
Other brain structures312
Histological findings321
Conclusions328
14Methodological Issues339
Methodological issues in case collection and selection340
Methodological issues for studies of neurochemical pathology343
Methodological issues for morphometric studies345
15Neuropathological Consequences of Schizophrenia Treatments351
Neuropathological effects of antipsychotic drugs351
Neuropathological effects of other treatments361
Neuropathological effects of substance misuse362
Conclusions362
Index369

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