The Neuropathology of Schizophrenia: Progress and Interpretation / Edition 1

The Neuropathology of Schizophrenia: Progress and Interpretation / Edition 1

by Paul J. Harrison
     
 

ISBN-10: 0192629077

ISBN-13: 9780192629074

Pub. Date: 10/28/2000

Publisher: Oxford University Press, USA

The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview of this rapidly moving field. It starts by describing the findings derived

Overview

The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature thought to be central to understanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these findings, such as the neurodevelopmental hypothesis. Finally, there are chapters considering the conceptual and methodological problems affecting the subject. This is a timely and unique book on this classic and controversial issue, with contributions from many of the leading international experts in the field.

Product Details

ISBN-13:
9780192629074
Publisher:
Oxford University Press, USA
Publication date:
10/28/2000
Series:
Oxford Medical Publications Series
Edition description:
New Edition
Pages:
392
Product dimensions:
6.40(w) x 9.30(h) x 1.00(d)

Table of Contents

Introduction
1. Structural imaging findings and macroscopic pathology
2. Hippocampal pathology
3. Cortical pathology: a new generation of quantitative microscopic findings
4. Synaptic pathology
5. Gliosis and its implications for the disease process
6. Cerebral asymmetry
7. Functional imaging and neural circuitry in schizophrenia
8. Neuropathology and the neurodevelopmental model
9. Cortical development and schizophrenia
10. The organization of cortical circuitry
11. Perspectives from other diseases and lesions
12. Animal models of schizophrenia
13. A sceptical view of the neuropathology of schizophrenia
14. Methodological issues
15. Neuropathological consequences of schizophrenia treatments

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