The Neuropathology of Schizophrenia: Progress and Interpretation / Edition 1

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New York 2004 Hardcover New 0192629077. AVOID WEEKS OF DELAY ELSEWHERE. --374 pages; with no writing or markings to the text. Small bump to lower corner of back cover.

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Overview

The neuropathology of schizophrenia is one of the most controversial areas of research in psychiatry; however, in the last twenty years, there have been significant advances in our understanding of the topic. This book provides a much needed, balanced, comprehensive and up-to-date overview of this rapidly moving field. It starts by describing the findings derived from new imaging techniques and histological studies, focusing specifically on the morphology, arrangement and connectivity of the neurons making up the cortical cytoarchitecture, a feature thought to be central to understanding the pathology. This is followed by critical appraisal of the various interpretations placed upon these findings, such as the neurodevelopmental hypothesis. Finally, there are chapters considering the conceptual and methodological problems affecting the subject. This is a timely and unique book on this classic and controversial issue, with contributions from many of the leading international experts in the field.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Scott Levine, MD (Rush University Medical Center)
Description: This book presents an interesting, broad, and surprisingly balanced survey of the research done on the neuropathology of schizophrenia.
Purpose: The editors and authors have attempted to survey the progress made toward understanding the microscopic and gross neuropathologic findings correlated with schizophrenia. Unlike many other surveys, this book (often excruciatingly) balances the promise and significance of these studies' findings with the methodological problems that continue to temper these findings.
Audience: Although the targeted audience is not named, this text would likely be very helpful for graduate students seeking a balanced survey of the current research in this field. Psychiatric (and, perhaps, some neurology) practitioners who are interested in a balanced survey of the progress made in this field will also find this welcome, but may be disappointed that the clinical utility of this knowledge base is still quite limited.
Features: Explanations of findings are clearly presented, and the illustrations are, for the most part, helpful. However, tables that attempt to provide a comprehensive survey of studies about certain subjects, and the limitations of these studies, are often long and cluttered. References are voluminous and current.
Assessment: This book fulfills its purpose to broadly and fairly present the progress being made in this field.
Scott Levine
This book presents an interesting, broad, and surprisingly balanced survey of the research done on the neuropathology of schizophrenia. "The editors and authors have attempted to survey the progress made toward understanding the microscopic and gross neuropathologic findings correlated with schizophrenia. Unlike many other surveys, this book (often excruciatingly) balances the promise and significance of these studies' findings with the methodological problems that continue to temper these findings. "Although the targeted audience is not named, this text would likely be very helpful for graduate students seeking a balanced survey of the current research in this field. Psychiatric (and, perhaps, some neurology) practitioners who are interested in a balanced survey of the progress made in this field will also find this welcome, but may be disappointed that the clinical utility of this knowledge base is still quite limited. "Explanations of findings are clearly presented, and the illustrations are, for the most part, helpful. However, tables that attempt to provide a comprehensive survey of studies about certain subjects, and the limitations of these studies, are often long and cluttered. References are voluminous and current. "This book fulfills its purpose to broadly and fairly present the progress being made in this field.
Booknews
Editors Harrison (psychiatry, U. of Oxford) and Roberts (Opine Consultancy, Cambridge) present 15 contributions from researchers, academics, and clinicians in psychiatry and neuroscience addressing findings of the last 20 years in this controversial area of research. Early chapters describe findings from the use of new imaging techniques and histological studies, focusing particularly on the morphology, arrangement, and connectivity of the neurons making up the cortical cytoarchitecture. Subsequent contributions discuss topics including evidence in support and limitations of the neurodevelopmental model, perspectives from other diseases and lesions, animal models of schizophrenia, a sceptical view of the neuropathology of schizophrenia, methodological problems, and neuropathological consequences of treatments. Annotation c. Book News, Inc., Portland, OR (booknews.com)

3 Stars from Doody
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Product Details

  • ISBN-13: 9780192629074
  • Publisher: Oxford University Press, USA
  • Publication date: 10/28/2000
  • Series: Oxford Medical Publications Series
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 392
  • Product dimensions: 6.40 (w) x 9.30 (h) x 1.00 (d)

Table of Contents

List of contributors xi
Introduction 1
1 Structural Imaging Findings and Macroscopic Pathology 5
In vivo brain imaging in schizophrenia 7
Brain morphology in schizophrenia 8
Global versus regional changes 17
Structural abnormalities as part of a neural network 35
Timing and progression of structural abnormalities 36
Diagnostic specificity of the findings 38
Conclusions and future directions 39
2 Hippocampal Pathology 57
Neuroanatomy of the normal hippocampal formation 58
Gross morphometry of the hippocampal formation in schizophrenia 61
Hippocampal cytoarchitecture and neuronal morphometry in schizophrenia 62
Cognitive impairment, dementia, and investigations of neurodegeneration in schizophrenia 69
Regional specificity of hippocampal neuropathological findings 71
Concluding remarks 73
3 Cortical Pathology: a New Generation of Quantitative Microscopic Studies 81
Stereomorphometric studies 82
The cortical GABA system 86
The cortical glutamate system 88
The cortical dopamine system 91
Cortical pathology and the neurodevelopmental hypothesis 94
Conclusions 95
4 Synaptic Pathology 105
Assessment of synapses 105
Models of synaptic abnormalities in schizophrenia 114
Studies of synapses in schizophrenia 115
Discussion and conclusions 124
5 Gliosis and its Implications for the Disease Process 137
Glia and gliosis 137
Gliosis in schizophrenia 140
The meaning of an absence of gliosis 143
Conclusions 145
6 Cerebral Asymmetry 151
Structural cerebral asymmetries 152
Cerebral asymmetry in schizophrenia 155
Conclusions 162
7 Functional Imaging and Neural Circuitry in Schizophrenia 173
Applied neuroimaging and the neuropathology of schizophrenia 173
Functional imaging techniques 175
Functional imaging and neurocircuitry 177
Corticothalamocerebellar circuitry and cognitive dysmetria in schizophrenia 182
Summary and conclusion 184
8 Neuropathology and the Neurodevelopmental Model 189
Evidence supporting a neurodevelopmental origin of schizophrenia 190
Evidence against schizophrenia as a neurodegenerative disorder 193
Neuropathological findings and the neurodevelopmental model 195
Limitations of the neurodevelopmental model 202
9 Cortical Development and Schizophrenia 213
Molecular basis for the organisation of the forebrain 215
Pattern formation and its functional consequences 223
Fate determination 227
Concluding remarks 229
10 The Organization of Cortical Circuitry 235
A model system for circuitry analysis: the primate dorsolateral prefrontal cortex 236
Cortical neuron types 237
Laminar arrangement of neurons 239
Organization of efferent projections 241
Organization and termination of afferent projections 242
Vulnerable prefrontal cortex circuitry in schizophrenia 245
11 Perspectives from other Diseases and Lesions 257
Neuropathology and diagnostic issues 257
Diseases sharing non-specific pathological features with schizophrenia 258
Disorders in which schizophrenia-like symptoms may occur 262
Normal determinants of neuronal parmeters and the effects of experimental lesions 265
Suggestions for future studies 268
12 Animal Models of Schizophrenia 277
Modeling schizophrenia in animals: some general considerations 278
Neurodevelopmental animal models of schizophrenia 280
Future approaches to modeling schizophrenia in animals 285
13 A Sceptical View of the Neuropathology of Schizophrenia 291
Overall brain dimensions 292
Lateral ventricular enlargement 298
Regional cerebral volumes 304
Temporal lobe limbic structures 310
Other brain structures 312
Histological findings 321
Conclusions 328
14 Methodological Issues 339
Methodological issues in case collection and selection 340
Methodological issues for studies of neurochemical pathology 343
Methodological issues for morphometric studies 345
15 Neuropathological Consequences of Schizophrenia Treatments 351
Neuropathological effects of antipsychotic drugs 351
Neuropathological effects of other treatments 361
Neuropathological effects of substance misuse 362
Conclusions 362
Index 369
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