Neuropsychopharmacology: The Fifth Generation of Progress: An Official Publication of the American College of Neuropsychopharmacology / Edition 5

Neuropsychopharmacology: The Fifth Generation of Progress: An Official Publication of the American College of Neuropsychopharmacology / Edition 5

by Dennis Charney, Joseph T. Coyle, Charles Nemeroff

ISBN-10: 0781728371

ISBN-13: 9780781728379

Pub. Date: 02/28/2002

Publisher: Lippincott Williams & Wilkins

Receive FREE On-Line Access through the American College of Neuropsychopharmacology website when you purchase the book! Simply return the card enclosed in the product shrink wrap. A password will be sent to you via e-mail. For a sample chapter, and to learn more about the ACNP, click here.

Thoroughly updated and completely reorganized for a sharper


Receive FREE On-Line Access through the American College of Neuropsychopharmacology website when you purchase the book! Simply return the card enclosed in the product shrink wrap. A password will be sent to you via e-mail. For a sample chapter, and to learn more about the ACNP, click here.

Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of the full spectrum of neuropsychiatric disorders.

Nine sections focus on specific groups of disorders--disorders of development; schizophrenia and related disorders; anxiety and stress disorders; affective disorders; Alzheimer's and other dementias; substance use disorders; impulsive and compulsive disorders; movement disorders and paroxysmal disorders; and chronobiology and sleep disorders. Each group of disorders is discussed in detail, including clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation.

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Product Details

Lippincott Williams & Wilkins
Publication date:
Edition description:
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9.00(w) x 11.30(h) x 2.40(d)

Table of Contents

Section 1Neurotransmitter and Signal Transduction1
3Opioid Peptides and Their Receptors: Overview and Function in Pain Modulation35
5Regulation of G Protein-Coupled Receptors by Phosphorylation and Endocytosis59
6The Diverse Roles of L-Glutamic Acid in Brain Signal Transduction71
7Corticotropin-Releasing Factor: Physiology, Pharmacology and Role in Central Nervous System Disorders91
8Neurogenesis in Adult Brain110
11Synaptic Plasticity147
13Substance P and Related Tachykinins169
15Purinergic Neurotransmission191
16Neurotrophic Factors and Intracellular Signal Transduction Pathways207
17Regulation of Gene Expression217
Section 2Emerging Methods in Molecular Biology and Genetics229
18Using Human Genomics to Advance Neuropyschopharmacology231
19Gene Targeting and Transgenic Technologies241
20Gene Delivery Into the Brain Using Viral Vectors253
21Neuropsychopharmacology of Worms and Flies263
22Beyond Binding: Molecular and Cell Biological Approaches to Studying G Protein-Coupled Receptors275
23Applying Functional Genomics to Neuropsychopharmacology291
Section 3Emerging Imaging Technologies and Their Application to Psychiatric Research299
24Automated 3D Analysis of Large Brain MRI Databases301
25In Vivo Magnetic Resonance Spectroscopy Studies of the Glutamate and GABA Neurotransmitter Cycles and Functional Neuroenergetics315
26The Spatial, Temporal, and Interpretive Limits of Functional MRI343
27Diffusion Tensor Imaging357
28Activation Paradigms in Affective and Cognitive Neuroscience: Probing the Neuronal Circuitry Underlying Mood and Anxiety Disorders373
29Interactions Among Neuronal Systems Assessed With Functional Neuroimaging383
30Measuring Brain Connectivity with Functional Imaging and Transcranial Magnetic Stimulation (TMS)393
31In Vivo Molecular Imaging: Ligand Development and Research Applications411
32Event-Related Potentials and Magnetic Fields in the Human Brain427
Section 4Drug Discovery and Evaluation441
33The Role of Preclinical Models in the Development of Psychotropic Drugs445
34Proof of Concept: Functional Models for Drug Development in Humans457
35Ethical Aspects of Neuropsychiatric Research with Human Subjects475
36Regulatory Issues485
37Pharmacogenomics and Personalized Therapeutics in Psychiatry495
38Pharmacokinetics, Pharmacodynamics, and Drug Disposition507
39The Role of Pharmaceuticals in Mental Health Care Outcomes525
40Issues in Clinical Trial Designs537
Section 5Disorders of Development547
41The Molecular and Cellular Genetics of Autism549
42Current and Emerging Therapeutics of Autistic Disorder and Related Pervasive Developmental Disorders565
43Pathophysiology of Attention Deficit Hyperactivity Disorder577
44Learning Disorders597
45Psychosis in Childhood and Its Management613
46Behavioral Phenotypes of Neurodevelopmental Disorders: Portals into the Developing Brain625
Section 6Schizophrenia and Related Disorders639
47Schizophrenia: Course Over the Lifetime641
48Neurocognitive Functioning in Patients with Schizophrenia: An Overview657
49Molecular and Population Genetics of Schizophrenia671
50Animal Models Relevant to Schizophrenia Disorders689
51Endophenotypes in Studies of the Genetics of Schizophrenia703
52Neurochemistry of Schizophrenia: Glutamatergic Abnormalities717
53Neural Circuitry Approaches to Understanding the Pathophysiology of Schizophrenia729
54Functional Neuroimaging in Schizophrenia745
55Structural Magnetic Resonance Imaging in Schizophrenia757
56Therapeutics of Schizophrenia775
57The Economics of the Treatment of Schizophrenia809
58Mechanism of Action of Atypical Antipsychotic Drugs819
59Neurochemical and Neuropharmacological Imaging in Schizophrenia833
Section 7Anxiety and Stress Disorders857
60Anxiety and Stress Disorders: Course Over the Lifetime859
61Genetic and Other Vulnerability Factors For Anxiety and Stress Disorders867
62Animal Models and Endophenotypes of Anxiety and Stress Disorders883
63The Neurobiological Basis of Anxiety Disorders901
64Neural Circuitry of Anxiety and Stress Disorders931
65Structural and Functional Imaging of Anxiety and Stress Disorders953
66Current and Emerging Therapeutics of Anxiety and Stress Disorders967
67The Economic Burden of Anxiety and Stress Disorders981
68Mechanisms of Action of Anxiolytics993
Section 8Affective Disorders1007
69The Course of Depression1009
70Risk Factors for Major Depression and Bipolar Disorder1017
71Bipolar Disorders: Review of Molecular Genetic Linkage Studies1027
72Molecular and Cellular Mechanisms in Depression1039
73Neurocircuitry of Mood Disorders1051
74Structural and Functional Imaging of Affective Disorders1065
75Current and Emerging Therapeutics for Depression1081
76Electroconvulsive Therapy: Sixty Years of Progress and a Comparison with Transcranial Magnetic Stimulation and Vagal Nerve Stimulation1097
77Current and Emerging Treatments for Acute Mania and Long Term Prophylaxis for Bipolar Disorder1109
78Cost Effectiveness of the Newer Generation of Antidepressants1119
79Mechanism of Action of Antidepressants and Mood-Stabilizers1139
80Hormonal and Gender Influences on Mood Regulation1165
81Depression and the Medically Ill1179
Section 9Alzheimers and Other Dementias1187
82Alzheimer's Disease: From Earliest Symptoms to End Stage1189
83Molecular Genetics of Alzheimer's Disease1199
84Transgenic Mouse Models of Alzheimer's Disease1215
85Cell and Molecular Neuropathology of Alzheimer's Disease1221
86Structural and Functional Brain Imaging of Alzheimer's Disease1231
87Current and Experimental Therapeutics of Alzheimer's Disease1243
88Alzheimer's Disease: Treatment of Noncognitive Behavioral Abnormalities1253
89Cost-Effectiveness of Therapeutics for Alzheimer's Disease1267
90Neuropsychiatric Manifestations of HIV-1 Infection and AIDS1281
91Dementia with Lewy Bodies1301
92Molecular Pathophysiology of Stroke1317
93Current and Experimental Treatment of Stroke1327
94Tau Protein and Tauopathy1339
Section 10Substance use Disorders1355
95Neurocircuitry of Addiction1357
96Molecular and Cellular Bilogy of Addiction1367
97Recent Advances in Animal Models of Drug Addiction1381
98Vulnerability Factors for Alcoholism1399
99Molecular and Cellular Genetics of Alcohol Addiction1413
100Ethanol Abuse, Dependence, and Withdrawal: Neurobiology and Clinical Implications1423
101Alcoholism Pharmacotherapy1445
102Pathophysiology and Treatment of Cocaine Dependence1461
103Application of Imaging Technologies in the Investigation of Drug Addiction1475
104Molecular and Cellular Neurobiology and Pathophysiology of Opiate Addiction1491
105Current and Experimental Therapeutics for the Treatment of Opioid Addiction1507
107Therapeutics for Nicotine Addiction1533
108Psychedelic Drugs1545
109Epidemiology of Drug Dependence1557
110Neuroimaging of Cocaine Craving States: Cessation, Stimulant Administration, and Drug Cue Paradigms1575
Section 11Impulsive and Compulsive Disorders1591
111The Course and Clinical Features of Obsessive Compulsive Disorder1593
112The Pathophysiology and Genetics of Obsessive Compulsive Disorder1609
113Imaging and Neurocircuitry of OCD1621
114Current and Experimental Therapeutics of Obsessive-Compulsive Disorder1647
115The Behavioral Neuroscience of Eating1665
116Psychopharmacology of Eating Disorders1675
117Tourette's Syndrome and Related Tic Disorders1685
118Animal Models of Aggression1699
119Pathophysiology and Treatment of Aggression1709
120Pathological Gambling and Impulse Control Disorders1725
121Compulsive and Impulsive Aspects of Self-Injurious Behavior1743
Section 12Movement Disorders and Paroxysmal Disorders1759
122Neurocircuitry of Parkinson's Disease1761
123Pathophysiology of Parkinson's Disease1781
124Current and Experimental Therapeutics of Parkinson's Disease1795
125Huntington's Disease1817
126Clinical Course and Cellular Pathology of Tardive Dyskinesia1831
127Temporal Lobe Epilepsy: Renewed Emphasis on Extrahippocampal Areas1843
Section 13Chronobiology and Sleep Disorders1857
128Basic Mechanisms of Sleep: New Evidence on the Neuroanatomy and Neuromodulation of the NREM-REM Cycle1859
129Circadian Phase Sleep and Mood Disorders1879
130Sleep Loss and Sleepiness: Physiological and Neurobehavioral Effects1895
131Pathophysiological and Pharmacological Aspects of the Sleep Disorder Narcolepsy1907
132Basic Mechanisms of Sedative/Hypnotics1923
133Current and Experimental Therapeutics of Insomnia1931
134Sleep Disturbances Associated with Neuropsychiatric Disease1945
Subject Index1961

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