Neuropsychopharmacology: The Fifth Generation of Progress: An Official Publication of the American College of Neuropsychopharmacology / Edition 5

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Thoroughly updated and completely reorganized for a sharper clinical focus, the Fifth Edition of this world-renowned classic synthesizes the latest advances in basic neurobiology, biological psychiatry, and clinical neuropsychopharmacology. The book establishes a critical bridge connecting new discoveries in molecular and cellular biology, genetics, and neuroimaging with the etiology, diagnosis, and treatment of the full spectrum of neuropsychiatric disorders.

Nine sections focus on specific groups of disorders--disorders of development; schizophrenia and related disorders; anxiety and stress disorders; affective disorders; Alzheimer's and other dementias; substance use disorders; impulsive and compulsive disorders; movement disorders and paroxysmal disorders; and chronobiology and sleep disorders. Each group of disorders is discussed in detail, including clinical course, genetics, neurobiology, neuroimaging, and current and emerging therapeutics. Four sections cover neurotransmitter and signal transduction, emerging methods in molecular biology and genetics, emerging imaging technologies and their psychiatric applications, and drug discovery and evaluation.

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Editorial Reviews

From The Critics
This official publication of the American College of Neuropsychopharmacology details advances in both the basic science and clinical application of recent research in the field, and demonstrates the prospects for even greater future advances. The 134 contributions by clinical experts and researchers discuss neurotransmitter and signal transduction; emerging methods in molecular biology and genetics; emerging imaging technologies and their application to psychiatric research; drug discovery and evaluation; developmental, schizophrenic, anxiety and stress, affective, substance use, impulsive and compulsive, movement, paroxysmal, chronobiology and sleep disorders; and Alzheimers and other dementias. Edited by Davis (Mount Sinai School of Medicine), Dennis Charney (National Institute of Mental Health), Joseph T. Coyle (Harvard Medical School), and Charles Nemeroff (Emory U. School of Medicine). Annotation c. Book News, Inc., Portland, OR (
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Product Details

  • ISBN-13: 9780781728379
  • Publisher: Lippincott Williams & Wilkins
  • Publication date: 2/28/2002
  • Edition description: PACKAGE
  • Edition number: 5
  • Pages: 2080
  • Product dimensions: 9.00 (w) x 11.30 (h) x 2.40 (d)

Table of Contents

Contributors xi
Preface xxi
Section 1 Neurotransmitter and Signal Transduction 1
1 Acetylcholine 3
2 Serotonin 15
3 Opioid Peptides and Their Receptors: Overview and Function in Pain Modulation 35
4 Norepinephrine 47
5 Regulation of G Protein-Coupled Receptors by Phosphorylation and Endocytosis 59
6 The Diverse Roles of L-Glutamic Acid in Brain Signal Transduction 71
7 Corticotropin-Releasing Factor: Physiology, Pharmacology and Role in Central Nervous System Disorders 91
8 Neurogenesis in Adult Brain 110
9 Dopamine 120
10 Astrocytes 133
11 Synaptic Plasticity 147
12 GABA 159
13 Substance P and Related Tachykinins 169
14 Histamine 179
15 Purinergic Neurotransmission 191
16 Neurotrophic Factors and Intracellular Signal Transduction Pathways 207
17 Regulation of Gene Expression 217
Section 2 Emerging Methods in Molecular Biology and Genetics 229
18 Using Human Genomics to Advance Neuropyschopharmacology 231
19 Gene Targeting and Transgenic Technologies 241
20 Gene Delivery Into the Brain Using Viral Vectors 253
21 Neuropsychopharmacology of Worms and Flies 263
22 Beyond Binding: Molecular and Cell Biological Approaches to Studying G Protein-Coupled Receptors 275
23 Applying Functional Genomics to Neuropsychopharmacology 291
Section 3 Emerging Imaging Technologies and Their Application to Psychiatric Research 299
24 Automated 3D Analysis of Large Brain MRI Databases 301
25 In Vivo Magnetic Resonance Spectroscopy Studies of the Glutamate and GABA Neurotransmitter Cycles and Functional Neuroenergetics 315
26 The Spatial, Temporal, and Interpretive Limits of Functional MRI 343
27 Diffusion Tensor Imaging 357
28 Activation Paradigms in Affective and Cognitive Neuroscience: Probing the Neuronal Circuitry Underlying Mood and Anxiety Disorders 373
29 Interactions Among Neuronal Systems Assessed With Functional Neuroimaging 383
30 Measuring Brain Connectivity with Functional Imaging and Transcranial Magnetic Stimulation (TMS) 393
31 In Vivo Molecular Imaging: Ligand Development and Research Applications 411
32 Event-Related Potentials and Magnetic Fields in the Human Brain 427
Section 4 Drug Discovery and Evaluation 441
33 The Role of Preclinical Models in the Development of Psychotropic Drugs 445
34 Proof of Concept: Functional Models for Drug Development in Humans 457
35 Ethical Aspects of Neuropsychiatric Research with Human Subjects 475
36 Regulatory Issues 485
37 Pharmacogenomics and Personalized Therapeutics in Psychiatry 495
38 Pharmacokinetics, Pharmacodynamics, and Drug Disposition 507
39 The Role of Pharmaceuticals in Mental Health Care Outcomes 525
40 Issues in Clinical Trial Designs 537
Section 5 Disorders of Development 547
41 The Molecular and Cellular Genetics of Autism 549
42 Current and Emerging Therapeutics of Autistic Disorder and Related Pervasive Developmental Disorders 565
43 Pathophysiology of Attention Deficit Hyperactivity Disorder 577
44 Learning Disorders 597
45 Psychosis in Childhood and Its Management 613
46 Behavioral Phenotypes of Neurodevelopmental Disorders: Portals into the Developing Brain 625
Section 6 Schizophrenia and Related Disorders 639
47 Schizophrenia: Course Over the Lifetime 641
48 Neurocognitive Functioning in Patients with Schizophrenia: An Overview 657
49 Molecular and Population Genetics of Schizophrenia 671
50 Animal Models Relevant to Schizophrenia Disorders 689
51 Endophenotypes in Studies of the Genetics of Schizophrenia 703
52 Neurochemistry of Schizophrenia: Glutamatergic Abnormalities 717
53 Neural Circuitry Approaches to Understanding the Pathophysiology of Schizophrenia 729
54 Functional Neuroimaging in Schizophrenia 745
55 Structural Magnetic Resonance Imaging in Schizophrenia 757
56 Therapeutics of Schizophrenia 775
57 The Economics of the Treatment of Schizophrenia 809
58 Mechanism of Action of Atypical Antipsychotic Drugs 819
59 Neurochemical and Neuropharmacological Imaging in Schizophrenia 833
Section 7 Anxiety and Stress Disorders 857
60 Anxiety and Stress Disorders: Course Over the Lifetime 859
61 Genetic and Other Vulnerability Factors For Anxiety and Stress Disorders 867
62 Animal Models and Endophenotypes of Anxiety and Stress Disorders 883
63 The Neurobiological Basis of Anxiety Disorders 901
64 Neural Circuitry of Anxiety and Stress Disorders 931
65 Structural and Functional Imaging of Anxiety and Stress Disorders 953
66 Current and Emerging Therapeutics of Anxiety and Stress Disorders 967
67 The Economic Burden of Anxiety and Stress Disorders 981
68 Mechanisms of Action of Anxiolytics 993
Section 8 Affective Disorders 1007
69 The Course of Depression 1009
70 Risk Factors for Major Depression and Bipolar Disorder 1017
71 Bipolar Disorders: Review of Molecular Genetic Linkage Studies 1027
72 Molecular and Cellular Mechanisms in Depression 1039
73 Neurocircuitry of Mood Disorders 1051
74 Structural and Functional Imaging of Affective Disorders 1065
75 Current and Emerging Therapeutics for Depression 1081
76 Electroconvulsive Therapy: Sixty Years of Progress and a Comparison with Transcranial Magnetic Stimulation and Vagal Nerve Stimulation 1097
77 Current and Emerging Treatments for Acute Mania and Long Term Prophylaxis for Bipolar Disorder 1109
78 Cost Effectiveness of the Newer Generation of Antidepressants 1119
79 Mechanism of Action of Antidepressants and Mood-Stabilizers 1139
80 Hormonal and Gender Influences on Mood Regulation 1165
81 Depression and the Medically Ill 1179
Section 9 Alzheimers and Other Dementias 1187
82 Alzheimer's Disease: From Earliest Symptoms to End Stage 1189
83 Molecular Genetics of Alzheimer's Disease 1199
84 Transgenic Mouse Models of Alzheimer's Disease 1215
85 Cell and Molecular Neuropathology of Alzheimer's Disease 1221
86 Structural and Functional Brain Imaging of Alzheimer's Disease 1231
87 Current and Experimental Therapeutics of Alzheimer's Disease 1243
88 Alzheimer's Disease: Treatment of Noncognitive Behavioral Abnormalities 1253
89 Cost-Effectiveness of Therapeutics for Alzheimer's Disease 1267
90 Neuropsychiatric Manifestations of HIV-1 Infection and AIDS 1281
91 Dementia with Lewy Bodies 1301
92 Molecular Pathophysiology of Stroke 1317
93 Current and Experimental Treatment of Stroke 1327
94 Tau Protein and Tauopathy 1339
Section 10 Substance use Disorders 1355
95 Neurocircuitry of Addiction 1357
96 Molecular and Cellular Bilogy of Addiction 1367
97 Recent Advances in Animal Models of Drug Addiction 1381
98 Vulnerability Factors for Alcoholism 1399
99 Molecular and Cellular Genetics of Alcohol Addiction 1413
100 Ethanol Abuse, Dependence, and Withdrawal: Neurobiology and Clinical Implications 1423
101 Alcoholism Pharmacotherapy 1445
102 Pathophysiology and Treatment of Cocaine Dependence 1461
103 Application of Imaging Technologies in the Investigation of Drug Addiction 1475
104 Molecular and Cellular Neurobiology and Pathophysiology of Opiate Addiction 1491
105 Current and Experimental Therapeutics for the Treatment of Opioid Addiction 1507
106 Marijuana 1519
107 Therapeutics for Nicotine Addiction 1533
108 Psychedelic Drugs 1545
109 Epidemiology of Drug Dependence 1557
110 Neuroimaging of Cocaine Craving States: Cessation, Stimulant Administration, and Drug Cue Paradigms 1575
Section 11 Impulsive and Compulsive Disorders 1591
111 The Course and Clinical Features of Obsessive Compulsive Disorder 1593
112 The Pathophysiology and Genetics of Obsessive Compulsive Disorder 1609
113 Imaging and Neurocircuitry of OCD 1621
114 Current and Experimental Therapeutics of Obsessive-Compulsive Disorder 1647
115 The Behavioral Neuroscience of Eating 1665
116 Psychopharmacology of Eating Disorders 1675
117 Tourette's Syndrome and Related Tic Disorders 1685
118 Animal Models of Aggression 1699
119 Pathophysiology and Treatment of Aggression 1709
120 Pathological Gambling and Impulse Control Disorders 1725
121 Compulsive and Impulsive Aspects of Self-Injurious Behavior 1743
Section 12 Movement Disorders and Paroxysmal Disorders 1759
122 Neurocircuitry of Parkinson's Disease 1761
123 Pathophysiology of Parkinson's Disease 1781
124 Current and Experimental Therapeutics of Parkinson's Disease 1795
125 Huntington's Disease 1817
126 Clinical Course and Cellular Pathology of Tardive Dyskinesia 1831
127 Temporal Lobe Epilepsy: Renewed Emphasis on Extrahippocampal Areas 1843
Section 13 Chronobiology and Sleep Disorders 1857
128 Basic Mechanisms of Sleep: New Evidence on the Neuroanatomy and Neuromodulation of the NREM-REM Cycle 1859
129 Circadian Phase Sleep and Mood Disorders 1879
130 Sleep Loss and Sleepiness: Physiological and Neurobehavioral Effects 1895
131 Pathophysiological and Pharmacological Aspects of the Sleep Disorder Narcolepsy 1907
132 Basic Mechanisms of Sedative/Hypnotics 1923
133 Current and Experimental Therapeutics of Insomnia 1931
134 Sleep Disturbances Associated with Neuropsychiatric Disease 1945
Subject Index 1961
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