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Doody's Review ServiceReviewer: Hassan Ahmed Al-Shatoury, MD (University of Illinois at Chicago College of Medicine)
Description: In this book, neurosteroids are clearly distinguished from other types of steroids. A large number of studies that focus on biosynthesis, metabolism, and different effects of neurosteroids on the nervous system are discussed. There is also an explanation of how these agents can be of significant therapeutic value in many neurological disorders.
Purpose: The purpose is to make the reader understand the physiochemical properties of neurosteroids to see how they may be used as pharmacological agents. The objectives fulfilled in this book are worthy and meet those of the editors.
Audience: According to the editors, this book is written for neurobiologists, endocrinologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians. In addition, this book will probably also be of interest to practicing neurologists. The editors of have been involved with research on the subject for a long time and are among the pioneers in this field.
Features: The topics covered include the definition of neurosteroids and their biosynthesis and regulation. This is followed by a discussion of the different effects of these neurosteroids on the nervous system. The future and possible use of these compounds as pharmacological agents in clinical practice are also discussed. In addition, the authors talk about the different actions of neurosteroids on the nervous system receptors. The chapters on their effects on the GABAergic receptors are especially well written. This is one of the first books devoted entirely to neurosteroids, and many studies done in this field over the past 15 years are summarized.
Assessment: This is a unique text in the field of neurosteroids. It is based on research spanning many years and places the reader on the first step of studying these pharmacological agents that may be of important therapeutic value especially in neurotrophicity, behavior, and age-related cerebral dysfunction. This is a rediscovery of an exciting field of research for all neuroscientists.