Neurosteroids: A New Regulatory Function in the Nervous System / Edition 1

Hardcover (Print)
Used and New from Other Sellers
Used and New from Other Sellers
from $39.83
Usually ships in 1-2 business days
(Save 84%)
Other sellers (Hardcover)
  • All (4) from $39.83   
  • New (1) from $166.89   
  • Used (3) from $39.83   
Close
Sort by
Page 1 of 1
Showing All
Note: Marketplace items are not eligible for any BN.com coupons and promotions
$166.89
Seller since 2007

Feedback rating:

(23307)

Condition:

New — never opened or used in original packaging.

Like New — packaging may have been opened. A "Like New" item is suitable to give as a gift.

Very Good — may have minor signs of wear on packaging but item works perfectly and has no damage.

Good — item is in good condition but packaging may have signs of shelf wear/aging or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Acceptable — item is in working order but may show signs of wear such as scratches or torn packaging. All specific defects should be noted in the Comments section associated with each item.

Used — An item that has been opened and may show signs of wear. All specific defects should be noted in the Comments section associated with each item.

Refurbished — A used item that has been renewed or updated and verified to be in proper working condition. Not necessarily completed by the original manufacturer.

New
BRAND NEW

Ships from: Avenel, NJ

Usually ships in 1-2 business days

  • Canadian
  • International
  • Standard, 48 States
  • Standard (AK, HI)
Page 1 of 1
Showing All
Close
Sort by

Overview

Etienne-Emile Baulieu, the discoverer of neurosteroids, and a panel of distinguished scientists and clinical researchers exhaustively and critically review all facets of neurosteroids involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. These contributors illuminate the role of neurosteroids in brain development and plasticity and detail their neuromodulatory influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Clearly pointing the way toward novel pharmaceutical agents that may be of significant therapeutic value, particularly with regard to aging mental functions, Neurosteroids: A New Regulatory Function in the Nervous System offers neurobiologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians the first comprehensive, state-of-the-art review of these important bioactive molecules.

The book contains black-and-white illustrations.

It is recognized that steroids, which are synthesized from cholesterol in endocrine glands, influence the development and function of the brain. This book unveils new physiological properties of neurosteroids, the related steroids that can form and metabolize in the brain, as well as throughout the entire nervous system. It addresses the involvement of neurosteroids in the function of the GABA-receptor and other neurotransmitter receptors such as nicotinic, NMDA, and sigma receptors. It reveals the trophic effects on neurons in culture, glial cells both in vitro and in vivo, Schwann cells, and oligodendrocytes. These current and innovative discussions may be the key to discovering new approaches to the repair of the nervous system after trauma and/or neurodegenerative diseases.

Read More Show Less

Editorial Reviews

Doody's Review Service
Reviewer: Hassan Ahmed Al-Shatoury, MD (University of Illinois at Chicago College of Medicine)
Description: In this book, neurosteroids are clearly distinguished from other types of steroids. A large number of studies that focus on biosynthesis, metabolism, and different effects of neurosteroids on the nervous system are discussed. There is also an explanation of how these agents can be of significant therapeutic value in many neurological disorders.
Purpose: The purpose is to make the reader understand the physiochemical properties of neurosteroids to see how they may be used as pharmacological agents. The objectives fulfilled in this book are worthy and meet those of the editors.
Audience: According to the editors, this book is written for neurobiologists, endocrinologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians. In addition, this book will probably also be of interest to practicing neurologists. The editors of have been involved with research on the subject for a long time and are among the pioneers in this field.
Features: The topics covered include the definition of neurosteroids and their biosynthesis and regulation. This is followed by a discussion of the different effects of these neurosteroids on the nervous system. The future and possible use of these compounds as pharmacological agents in clinical practice are also discussed. In addition, the authors talk about the different actions of neurosteroids on the nervous system receptors. The chapters on their effects on the GABAergic receptors are especially well written. This is one of the first books devoted entirely to neurosteroids, and many studies done in this field over the past 15 years are summarized.
Assessment: This is a unique text in the field of neurosteroids. It is based on research spanning many years and places the reader on the first step of studying these pharmacological agents that may be of important therapeutic value especially in neurotrophicity, behavior, and age-related cerebral dysfunction. This is a rediscovery of an exciting field of research for all neuroscientists.
Hassan Ahmed Al-Shatoury
In this book, neurosteroids are clearly distinguished from other types of steroids. A large number of studies that focus on biosynthesis, metabolism, and different effects of neurosteroids on the nervous system are discussed. There is also an explanation of how these agents can be of significant therapeutic value in many neurological disorders. The purpose is to make the reader understand the physiochemical properties of neurosteroids to see how they may be used as pharmacological agents. The objectives fulfilled in this book are worthy and meet those of the editors. According to the editors, this book is written for neurobiologists, endocrinologists, psychiatrists, neurosurgeons, pharmacologists, and geriatricians. In addition, this book will probably also be of interest to practicing neurologists. The editors of have been involved with research on the subject for a long time and are among the pioneers in this field. The topics covered include the definition of neurosteroids and their biosynthesis and regulation. This is followed by a discussion of the different effects of these neurosteroids on the nervous system. The future and possible use of these compounds as pharmacological agents in clinical practice are also discussed. In addition, the authors talk about the different actions of neurosteroids on the nervous system receptors. The chapters on their effects on the GABAergic receptors are especially well written. This is one of the first books devoted entirely to neurosteroids, and many studies done in this field over the past 15 years are summarized. This is a unique text in the field of neurosteroids. It is based on research spanning many years and places the reader onthe first step of studying these pharmacological agents that may be of important therapeutic value especially in neurotrophicity, behavior, and age-related cerebral dysfunction. This is a rediscovery of an exciting field of research for all neuroscientists.
Booknews
Not really new, but recently discovered by Baulieu biochemistry and human reproduction, College of France, Paris himself. Scientists and clinical researchers join him in reviewing all facets of neurosteroids known to be involved in behavior, stress, memory, depression, anxiety, aging of the brain, and neurodegenerative diseases. Pointing the way to new pharmaceutical agents that may be of significant therapeutic value in aging mental functions and other problems, they look at the role of neurosteroids in brain development and plasticity, and their neuromodulary influence on GABAA, ionotropic glutamate receptors, acetylcholine receptors, sigma receptors, and calcium channels. Annotation c. Book News, Inc., Portland, OR booknews.com

4 Stars! from Doody
Read More Show Less

Product Details

  • ISBN-13: 9780896035454
  • Publisher: Springer-Verlag New York, LLC
  • Publication date: 7/28/1999
  • Series: Contemporary Endocrinology Series , #16
  • Edition description: 1999
  • Edition number: 1
  • Pages: 379
  • Product dimensions: 7.30 (w) x 10.30 (h) x 0.98 (d)

Table of Contents

Preface
Contributors
List of Main Steroids and Enzymes Involved in Steroid Metabolism
1 Neurosteroids: From Definition and Biochemistry to Physiopathologic Function 1
2 Molecular Biology and Developmental Regulation of the Enzymes Involved in the Biosynthesis and Metabolism of Neurosteroids 27
3 Cytochrome P450 in the Central Nervous System 51
4 Steroidogenic Factor 1 Plays Key Roles in Adrenal and Gonadal Development and in Endocrine Function 67
5 Peripheral-Type Benzodiazepine Receptor: Role in the Regulation of Steroid and Neurosteroid Biosynthesis 75
6 Aspects of Hormonal Steroid Metabolism in the Nervous System 97
7 The Selective Interaction of Neurosteroids with the GABA[subscript A] Receptor 125
8 Potentiation of GABAergic Neurotransmission by Steroids 143
9 Neurosteroid Antagonists of the GABA[subscript A] Receptors 155
10 Modulation of Ionotropic Glutamate Receptors by Neuroactive Steroids 167
11 Steroidal Modulation of Sigma Receptor Function 191
12 Steroid Modulation of the Nicotinic Acetylcholine Receptor 207
13 Neuroactive Steroid Modulation of Neuronal Voltage-Gated Calcium Channels 225
14 Gonadal Hormone Regulation of Synaptic Plasticity in the Brain: What Is the Mechanism? 233
15 Steroid Effects on Brain Plasticity: Role of Glial Cells and Trophic Factors 255
16 Steroid Receptors in Brain Cell Membranes 269
17 Novel Mechanisms of Estrogen Action in the Developing Brain: Role of Steroid/Neurotrophin Interactions 293
18 Neurosteroids: Behavioral Studies 317
19 Remarkable Memory-Enhancing Effects of Pregnenolone Sulfate with Pheromone-Like Sensitivity: An Amplificatory Hypothesis 337
20 The Neuropsychopharmacological Potential of Neurosteroids 349
Index 365
Read More Show Less

Customer Reviews

Be the first to write a review
( 0 )
Rating Distribution

5 Star

(0)

4 Star

(0)

3 Star

(0)

2 Star

(0)

1 Star

(0)

Your Rating:

Your Name: Create a Pen Name or

Barnes & Noble.com Review Rules

Our reader reviews allow you to share your comments on titles you liked, or didn't, with others. By submitting an online review, you are representing to Barnes & Noble.com that all information contained in your review is original and accurate in all respects, and that the submission of such content by you and the posting of such content by Barnes & Noble.com does not and will not violate the rights of any third party. Please follow the rules below to help ensure that your review can be posted.

Reviews by Our Customers Under the Age of 13

We highly value and respect everyone's opinion concerning the titles we offer. However, we cannot allow persons under the age of 13 to have accounts at BN.com or to post customer reviews. Please see our Terms of Use for more details.

What to exclude from your review:

Please do not write about reviews, commentary, or information posted on the product page. If you see any errors in the information on the product page, please send us an email.

Reviews should not contain any of the following:

  • - HTML tags, profanity, obscenities, vulgarities, or comments that defame anyone
  • - Time-sensitive information such as tour dates, signings, lectures, etc.
  • - Single-word reviews. Other people will read your review to discover why you liked or didn't like the title. Be descriptive.
  • - Comments focusing on the author or that may ruin the ending for others
  • - Phone numbers, addresses, URLs
  • - Pricing and availability information or alternative ordering information
  • - Advertisements or commercial solicitation

Reminder:

  • - By submitting a review, you grant to Barnes & Noble.com and its sublicensees the royalty-free, perpetual, irrevocable right and license to use the review in accordance with the Barnes & Noble.com Terms of Use.
  • - Barnes & Noble.com reserves the right not to post any review -- particularly those that do not follow the terms and conditions of these Rules. Barnes & Noble.com also reserves the right to remove any review at any time without notice.
  • - See Terms of Use for other conditions and disclaimers.
Search for Products You'd Like to Recommend

Recommend other products that relate to your review. Just search for them below and share!

Create a Pen Name

Your Pen Name is your unique identity on BN.com. It will appear on the reviews you write and other website activities. Your Pen Name cannot be edited, changed or deleted once submitted.

 
Your Pen Name can be any combination of alphanumeric characters (plus - and _), and must be at least two characters long.

Continue Anonymously

    If you find inappropriate content, please report it to Barnes & Noble
    Why is this product inappropriate?
    Comments (optional)