New Biological Vistas on Schizophrenia

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Thirteen contributions summarize current thinking on the syndromes and genetics, neuropathology, and biochemical basis of schizophrenia, as well as new treatment strategies--pharmacological strategies for the neuroleptic nonresponder, atypical neuroleptics, and plasma levels, clinical effects, and low-dose strategies. Annotation c. Book News, Inc., Portland, OR (
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Table of Contents

A Note on the Series
Pt. I Syndromes and Genetics of Schizophrenia
1 New Perspectives on the Positive-Negative Distinction in Schizophrenia 3
2 Recent Advances in the Genetics of Schizophrenia 28
Pt. II Neuropathology of Schizophrenia
3 In Vivo Studies of Brain Morphology in Schizophrenia 57
4 The Neuropathology of Schizophrenia: Old and New Findings 82
5 Heterogeneity in Schizophrenia: Clinical and Biological Aspects 110
Pt. III Biochemical Theories of Schizophrenia
6 The Role of Dopamine in Schizophrenia 131
7 Neuroanatomical Specificity of Action of the Atypical Antipsychotics 158
8 Serotonergic Mechanisms in the Pathogenesis of Schizophrenia 182
9 [Gamma]-Type Endorphins and Schizophrenia 207
10 The PCP/NMDA Theory of Schizophrenia 222
Pt. IV New Treatment Strategies for Schizophrenia
11 Pharmacological Strategies for the Neuroleptic Nonresponder 241
12 Atypical Neuroleptics for the Treatment of Schizophrenia 259
13 Plasma Levels, Clinical Effects, and Low-Dose Strategies 273
Name Index 285
Subject Index 295
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