New Concepts in the Immunopathogenesis of CNS Infections

Overview

A shared interest in the mechanisms of host defense and a particular interest in tow forms of brain infection inspired the editors to bring together a group of 20 experts to discuss topics related to the immunopathogenesis of infections of the brain. The outcome is an outstanding collection of dissertation on the complex interplay between infection agents and host responses involved in central nervous system infections. This exciting new book strives to give the reader a current understanding, at a molecular ...
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Overview

A shared interest in the mechanisms of host defense and a particular interest in tow forms of brain infection inspired the editors to bring together a group of 20 experts to discuss topics related to the immunopathogenesis of infections of the brain. The outcome is an outstanding collection of dissertation on the complex interplay between infection agents and host responses involved in central nervous system infections. This exciting new book strives to give the reader a current understanding, at a molecular level, of the strategies used by the host to defend the brain. Direction for future research on immunopathogenesis and therapy for central nervous system infection sis incorporated.

The book contains black-and-white illustrations.

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Editorial Reviews

Doody's Review Service
Reviewer: Jose Romero, MD (Creighton University Medical Center)
Description: This book provides a series of reviews detailing the current understanding of the molecular strategies used by the host to protect the central nervous system (CNS) from infection due to pathogens ranging from parasites to prions. Additionally, in several chapters new concepts regarding the epidemiology, prevention, and treatment of CNS infections are highlighted.
Purpose: Edited and authored by recognized authorities in their fields, this publication succeeds in summarizing the currently available information regarding many aspects of the molecular immunopathogenesis of CNS infections.
Audience: Anyone wishing to be rapidly brought abreast of current knowledge in the areas covered in this book will find this publication useful. Although the focus on molecular mechanisms will undoubtedly draw the attention of individuals involved in basic science and clinical research of CNS infections, the clinical information contained will also be of interest to clinical subspecialists in the areas of neurology and infectious diseases.
Features: The initial chapters dealing with the hematogenous cells, astrocytes, microglia, cyto- and chemokines are particularly useful to someone unfamiliar with their roles within the CNS. The following chapters focus on common and uncommon infectious agents of the CNS such as JC virus, Borna virus, and prions. The many figures and photomicrographs are useful and of high quality. The tables, used liberally throughout the book, present their information in a clear and concise manner.
Assessment: This publication will be a useful addition to the libraries of involved in clinical or research aspects of CNS infections.
From The Critics
Reviewer: Jose Romero, MD(Creighton University Medical Center)
Description: This book provides a series of reviews detailing the current understanding of the molecular strategies used by the host to protect the central nervous system (CNS) from infection due to pathogens ranging from parasites to prions. Additionally, in several chapters new concepts regarding the epidemiology, prevention, and treatment of CNS infections are highlighted.
Purpose: Edited and authored by recognized authorities in their fields, this publication succeeds in summarizing the currently available information regarding many aspects of the molecular immunopathogenesis of CNS infections.
Audience: Anyone wishing to be rapidly brought abreast of current knowledge in the areas covered in this book will find this publication useful. Although the focus on molecular mechanisms will undoubtedly draw the attention of individuals involved in basic science and clinical research of CNS infections, the clinical information contained will also be of interest to clinical subspecialists in the areas of neurology and infectious diseases.
Features: The initial chapters dealing with the hematogenous cells, astrocytes, microglia, cyto- and chemokines are particularly useful to someone unfamiliar with their roles within the CNS. The following chapters focus on common and uncommon infectious agents of the CNS such as JC virus, Borna virus, and prions. The many figures and photomicrographs are useful and of high quality. The tables, used liberally throughout the book, present their information in a clear and concise manner.
Assessment: This publication will be a useful addition to the libraries of involved in clinical or research aspects of CNS infections.
Booknews
A group of 20 experts discuss topics related to the immunopathogenesis of infections of the brain, examining the complex interplay between infectious agents and host responses involved in central nervous system infections, and look at future directions for research in the field. Topics include cytokines and chemokines in defense and damage in the intact central nervous system, neurologic Lyme disease, herpes simplex infections of the central nervous system, and the genetics of multiple sclerosis. Material originated at an October 1999 meeting. Peterson is director of the Institute for Brain and Immune Disorders, Minneapolis Medical Research Foundation. Remington teaches medicine in the division of infectious diseases and geographic medicine at Stanford University School of Medicine. Annotation c. Book News, Inc., Portland, OR (booknews.com)

4 Stars! from Doody
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Product Details

  • ISBN-13: 9780632045280
  • Publisher: Wiley, John & Sons, Incorporated
  • Publication date: 10/10/2000
  • Edition description: New Edition
  • Edition number: 1
  • Pages: 400
  • Product dimensions: 6.26 (w) x 9.46 (h) x 0.90 (d)

Table of Contents

Contributors
Preface
1 Entry and Function of Hematogenous Cells in the Central Nervous System 1
2 Astrocytes and the Neuroimmunomodulatory Role of Interleukin-6 21
3 Microglia: Defenders of the Brain Against Viral Infection 39
4 Cytokines and Chemokines in Defense and Damage in the Intact CNS 51
5 Bacterial Meningitis: Epidemiology, Pathophysiology, and Immunobiology 84
6 Experimental Tuberculous Meningitis 107
7 Neurologic Lyme Disease 119
8 Immunopathogenesis of CNS Toxoplasmosis 143
9 Cryptococcal Meningoencephalitis 163
10 Herpes Simplex Infections of the Central Nervous System 188
11 The Biology and Clinical Consequence of JC Virus Infection in the Human Brain - Progressive Multifocal Leukoencephalopathy 205
12 Transmissible Spongiform Encephalopathies and Prion Protein 223
13 Alphavirus Encephalomyelitis: Determinants of Outcome 236
14 Macaque Models of the Neuropathogenesis of HIV Infection 249
15 Borna Disease Virus and the Brain 268
16 Immunocytotherapy of Persistent Viral Infection 289
17 Class I Major Histocompatibility Molecules Play a Critical Role in Resistance to Theiler's Virus Infection 296
18 The Genetics of Multiple Sclerosis 317
19 Simple Genetic Models of Human Neurologic Disease 337
Index 361
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