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Doody's Review ServiceReviewer: Jose Romero, MD (Creighton University Medical Center)
Description: This book provides a series of reviews detailing the current understanding of the molecular strategies used by the host to protect the central nervous system (CNS) from infection due to pathogens ranging from parasites to prions. Additionally, in several chapters new concepts regarding the epidemiology, prevention, and treatment of CNS infections are highlighted.
Purpose: Edited and authored by recognized authorities in their fields, this publication succeeds in summarizing the currently available information regarding many aspects of the molecular immunopathogenesis of CNS infections.
Audience: Anyone wishing to be rapidly brought abreast of current knowledge in the areas covered in this book will find this publication useful. Although the focus on molecular mechanisms will undoubtedly draw the attention of individuals involved in basic science and clinical research of CNS infections, the clinical information contained will also be of interest to clinical subspecialists in the areas of neurology and infectious diseases.
Features: The initial chapters dealing with the hematogenous cells, astrocytes, microglia, cyto- and chemokines are particularly useful to someone unfamiliar with their roles within the CNS. The following chapters focus on common and uncommon infectious agents of the CNS such as JC virus, Borna virus, and prions. The many figures and photomicrographs are useful and of high quality. The tables, used liberally throughout the book, present their information in a clear and concise manner.
Assessment: This publication will be a useful addition to the libraries of involved in clinical or research aspects of CNS infections.