New Trends in the Molecular and Biological Basis for Clinical Oncology / Edition 1

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More About This Textbook


Newly developed molecular target anticancer drugs have shown remarkable efficacy even in the treatment of intractable cancers such as hepatoma and renal cell carcinoma. As cancer research is becoming a multidisciplinary endeavor, close cooperation across the basic, translational, and clinical research fields holds the promise of further advances in cancer therapeutics. This book sets forth new strategies for development: cancer therapy targeting receptor tyrosine kinases with clinical utilization of new signaling regulations; interaction between cancer progression and extracellular environments such as inflammatory cytokines and the extracellular matrix; and investigation of biomarkers for personalized cancer therapy, with microarray analysis and pharmacogenomics technology. These and other findings from the latest investigations into cancer cell biology and therapeutics make this book an invaluable source for investigators in both the clinical and basic cancer research fields.

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Product Details

  • ISBN-13: 9784431886624
  • Publisher: Springer Japan
  • Publication date: 12/28/2008
  • Edition description: 2009
  • Edition number: 1
  • Pages: 192
  • Product dimensions: 6.20 (w) x 9.30 (h) x 0.60 (d)

Table of Contents

Foreword V

Preface VIII

Acknowledgement IX

Contributors XIII

Color Plates XIX

Part I RTK-Related Signaling

HER2 Overexpression Attenuates the Antiproliferative Effect of Aromatase Inhibitor in MCF-7 Breast Cancer Cells Stably Expressing Aromatase I. Shin T. Miller E. S. Wang C. L. Arteaga 3

Biomarker Research for Development of Molecular Target Agents K. Nishio T. Arao 29

Epidermal Growth Factor (EGF) Receptor Kinase Activity is Required for Tumor Necrosis Factor (TNF)-[alpha] Mediated Intestinal Epithelial Survival T. Yamaoka D. B. Polk T. Ohmori S. Kusumoto T. Sugiyama T. Shirai M. Nakashima K. Okuda T. Hirose T. Ohnishi N. Horichi M. Adachi 37

A Molecular Mechanism of Diminished Binding Activity between 15 bp Deletion Mutant EGFR and c-Cb1 Ubiquitin Ligase T. Ohmori T. Hosaka T. Kanome F. Inoue K. Ando T. Hirose T. Kadofuku M. Adachi 55

Part II Inflammation, Angiogenesis, and Tumor Progression

TGF[beta]-Mediated Epithelial Mesenchymal Transition and Metastasis in Skin and Head-and-Neck Cancer S. Bornstein G. W. Han K. Hoot S. L. Lu X. J. Wang 69

TGF-[beta] and Tumor Progression Mediated by Reactive Oxygen Species K. Nose T. Sugimoto M. Wakamatsu F. Ishikawa M. Shibanuma 81

Role of MT1-MMP in Tumor-Stromal Interaction M. Seiki 86

Role of Proinflammatory Prostaglandin E[subscript 2] in Bladder Tumor Progression S. Hara 92

Part III Biomarkers for Clinical Oncology

Molecular Biomarker for Lung Cancer H. Y. Chen P. C. Yang 99

Screening of Biomarker for Oral Squamous Cell Carcinoma Correlating with Clinicopathological Findings Using by Laser Microdissection and cDNA Microarray T. Irie G. Yamamoto T. Isobe T. Matsunaga T. Tachikawa 106

Biomarkers forClinical Oncology Y. Sasaki 117

Genome-Wide cDNA Microarray Screening of Gene Expression Profiles Correlated with Resistance to Anti-Cancer Drug Treatment and Radiation in Oral Squamous Cell Carcinoma S. Shintani 118

Part IV Poster Session

Drug Accumulation and Efflux Do not Contribute to Acquired Gefitinib Resistance S. Kusumoto T. Sugiyama M. Nakashima T. Yamaoka T. Hirose T. Ohnishi N. Horichi M. Adachi K. Nishio N. Saijo T. Kuroki T. Ohmori 127

Difference of EGFR-Binding Proteins between Wild Type and Mutant EGFR T. Kadofuku T. Kanome K. Nishio T. Kuroki T. Ohmori 132

Competitive Nuclear Export of Cyclin D1 and Hic-5 Regulates Anchorage-Dependence of Cell Growth and Survival K. Mori Y. Oshima K. Nose M. Shibanuma 139

Induction of Matrix Metalloprotease Gene Expression in an Endothelial Cell Line by Direct Interaction with Malignant Cells K. Egawa Y. Hasebe M. Shibanuma K. Nose 153

Expression of Rad21 Cleaved Products in Oral Epithelium G. Yamamoto T. Matsunaga T. Isobe T. Irie T. Tachikawa 157

Telomerase-Specific Replication-Selective Virotherapy for Oral Squamous Cell Carcinoma Cell Lines Y. Kurihara Y. Watanabe T. Kojima T. Shirota M. Hatori Y. Urata T. Fujiwara S. Shintani 168

Hypoxia Induces Resistance to 5-Fluorouracil in Oral Cancer Cells via G1 Phase Cell Cycle Arrest S. Yoshiba D. Ito T. Nagumo T. Shirota M. Hatori S. Shintani 184

Key Word Index 191

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