Nitric Oxide and Free Radicals in Peripheral Neurotransmission

by Stanley Kalsner (Editor)

Overview

"Nitric Oxide and Free Radicals in Peripheral Neurotransmission" is a welcome addition to the literature and describes current research into the role of nitric oxide in the peripheral nervous system and its associated organs. Topics covered range from general consideration of nitrergic transmission, in its broadest sense, to elaboration of our current understanding of the role of nitric oxide in transmission in individual peripheral organs, including its role as a backup, or alternate as well as chief transmitter. The influence of nitric oxide and related compounds on the more conventional modes of autonomic transmission are also considered. Aimed at students and researchers in the areas of neuroscience and physiology, "Nitric Oxide and Free Radicals in Peripheral Neurotransmission" also covers the emerging role of abnormal nitric oxide function in disease states and, where appropriate, as potential avenues of therapy.

Product Details

ISBN-13:	9780817640705
Publisher:	Birkhäuser Boston
Publication date:	06/16/2000
Series:	Nitric Oxide in Biology and Medicine , #2
Edition description:	2000
Pages:	357
Product dimensions:	6.10(w) x 9.25(h) x 0.03(d)

Table of Contents

1. On the Origin and Early Evolution of Neuronal Nitric Oxide Signaling: A Comparative Analysis.- 2. The Nitrergic Transmitter of the Anococcygeus: Lessons and Insights.- 3. Interactions Between Nitric Oxide and Other NANC Inhibitory Neurotransmitters in the Periphery: Clues from the Endothelium.- 4. Nitrergic Neurotransmission in the Lower Urinary Tract and Penile Erectile Tissues.- 5. Nitrergic Neurotransmission in the Enteric Nervous System.- 6. Nitric Oxide and Peripheral Neurotransmission in the Lung.- 7. Nitrergic Neurogenic Control of Resistance Blood Vessels.- 8. Is There Neural Control of Peripheral Resistance Arteries by Nitrergic Nerves?.- 9. Nitric Oxide, Perivascular Neural Transmission, and Migraine.- 10. Presynaptic Modulation of Peripheral Nitrergic Neurotransmission.- 11. Neural Nitric Oxide Synthase and Neutrophil Function.- 12. Nitric Oxide Toxicity in Neuronal Injury and Degeneration.- 13. Peroxynitrite and Nitrergic Neural Transmission: Pathophysiological Implications.- 14. Nitric Oxide, Peripheral Neuropathy, and Diabetes.- 15. Potential Clinical Impact of Nitric Oxide and Nitric Oxide Inhibitors in the Periphery.

Editorial Reviews

This is a summary of current research on the impact of nitric oxide released from neuronal and non-neuronal sources on peripheral neurotransmission. The purpose is to comprehensively review current literature in which the role of nitric oxide in modulating peripheral autonomic neurotransmission is investigated. These are worthy objectives considering the explosive impact that nitric oxide has on mammalian biology. The editor's objectives are adequately met. The book is intended as an authoritative reference for graduate level students and scientists currently doing research in this important area. The editor and I agree on the target audience. The book is credible and represents a cadre of some of the best researchers in this area. The origins of nitric oxide signaling are covered and the current state of knowledge on how nitric oxide modulates autonomic nerve function is detailed. The best part of the book is the succinctness in which this complex subject is summarized. It is rich in pictorial illustrations of complex mechanisms. The section on regulation of neuronal NOS activity is a bit weak. Then again, this could be due to the undeveloped state of this subject area. Personally I find this book to be an excellent resource for anyone interested in the area of NO modulation of the peripheral autonomic system. In particular it will be a valuable text for teaching professionals attempting to introduce this topic to students.

John Buchholz