Nitric Oxide and the Kidney: Physiology and Pathophysiology / Edition 1

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A number of remarkable recent breakthroughs have made the study of nitric oxide one of the most exciting fields in physiology and pathophysiology. This authoritative edited volume reviews the progress to date and opens perspectives to novel diagnostic and therapeutic strategies. The contributors are leading authorites, in most cases the investigators who have pioneered the ideas explored in the book.

Covers the biological chemistry of NO, distribution of NOSs in the kidney, role of NO system in renal pathophysiology.

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Editorial Reviews

This volume reviews recent breakthroughs in the study of nitric oxide in the fields of physiology, pathophysiology, internal medicine, and nephrology, opening perspectives to novel diagnostic and therapeutic strategies and providing an overview of the direction in which these studies are heading in the future. Topics include the chemistry of nitric oxide; the molecular biology of the enzymes generating it; physiological targets of nitric oxide in the kidney; and the role of this system in the pathogenesis and pathophysiology of various renal diseases, such as hypertension and preeclampsia. Annotation c. by Book News, Inc., Portland, Or.
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Product Details

  • ISBN-13: 9780412080616
  • Publisher: Springer US
  • Publication date: 9/5/2007
  • Edition description: 1997
  • Edition number: 1
  • Pages: 488
  • Product dimensions: 9.00 (w) x 6.00 (h) x 1.25 (d)

Table of Contents

I. General Biochemistry of NOSs and Cellular Actions of NO.- 1. The Biological Chemistry of NO.- 2. Role of NO and Nitrogen Intermediates in Regulation of Cell Functions.- 3. Nitric Oxide Synthases and Their Cofactors.- 4. Regulation of the NOS Gene Family.- 5. Role of NO in Cell Locomotion.- II. Renal Expression of NOSs and Production of NO.- 6. Metabolic Pathways and Cycles of L-Arginine Synthesis and Utilization.- 7. Distribution of NOSs in the Kidney.- III. NO and the Regulation of Renal Hemodynamics.- 8. Vascular Effects of NO.- 9. Role of NO in the Function of the Juxtaglomerular Apparatus.- 10. NOS in Mesangial Cells: Physiological and Pathophysiological Roles.- 11. Tubuloglomerular Feedback and Macula Densa-Derived NO.- 12. NO and the Renin System.- 13. NO and the Medullary Circulation.- IV. Role of NO system in Renal Pathophysiology.- 14. NO in Septic Shock.- 15. NO and Glomerulonephritis.- 16. NO in Acute Renal Failure.- 17. NO in Diabetic Nephropathy.- 18. NO and Hypertension.- 19. NO in Normal and Preeclamptic Pregnancy.- 20. Sickle Cell Disease and NO.- 21. A Putative Role of NO and Oxidant Injury in the Pathogenesis of Hemolytic Uremic Syndrome.- 22. Role of NO in Urinary Tract Infections.- 23. Role of the NO System in Urinary Tract Obstruction.

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